My protocol required a 17 courses (every 3 weeks). I finished over a year ago. I had fatigue, but it was hard to separate out there for a while from the chemo. I also had aching my legs. I still believe, though my oncologist disagrees, that my itching of my lower legs (I called it the heebie-jeebies) was related to my herceptin. I never had a rash or swelling or any difficulties breathing, but I did have very itchy skin that cleared up about one month after my herceptin treatments stopped.
All in all, it was less troublesome than chemo and I'm glad I had it.
IBC dx August 9/06
chemo August 11/06 - January 8/07
IMRT rads 5 weeks
surgery May 1/07 bilateral mastectomy (left modified radical, right simple)