-§»§«:*´`³¤³´`*:» Vicky «:*´`³¤³´`*:»§«§-
I'm still looking into all of this myself. Here's some info I found on the web that might be of use:
Leisha A. Emens and Nancy E. Davidson
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins,Baltimore, Maryland 21231-1000
Hormonal manipulation has been used for over 100 years to treat breast cancer. Ovarian ablation/suppression and tamoxifen are currently accepted adjuvant endocrinetherapies for premenopausal breast cancer. Methods of permanently ablating ovarian function include surgical oopho-rectomy and radiation-induced ovarian failure; medicalcastration with luteinizing hormone-releasing hormoneanalogues is a reversible approach. Adjuvant chemotherapyfrequently results in permanent amenorrhea and thus rep-resents an indirect form of ovarian ablation. Although earlyrandomized trials of ovarian ablation suffered from smallsample sizes and design flaws, a meta-analysis of their re-sults through the Early Breast Cancer Trialists’ Collabora-tive Group demonstrated a clear benefit from ovarian abla-tion as a single intervention in the adjuvant treatment ofwomen less than 50 years of age with breast cancer.
The ovary is the major site of estrogen production in the
premenopausal woman. A smaller amount of estrogen is pro-duced as a result of the aromatase-mediated conversion ofandrostenedione and testosterone to estrone and estradiol inextragonadal tissues. In contrast, peripheral aromatization is theprimary source of estrogen in postmenopausal women. Thismajor difference in the means of estrogen production mandatesdistinct strategies for disrupting its production in premenopausaland postmenopausal women with breast cancer. Accordingly,ovarian ablation/suppression is the most effective means ofdecreasing estrogen production in premenopausal women,whereas aromatase inhibition is emerging as the backbone ofhormonal therapy in postmenopausal women.
If you want ALL 27 pages, I can email it to you. I can't find the web link, but if you search under their names maybe it will come up.
Best of luck!