High Antinuclear Antibody Count & Cancer

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djoyg
Regular Member


Date Joined Jul 2006
Total Posts : 139
   Posted 7/13/2006 3:44 AM (GMT -6)   
Hi,

Is there anyone familiar with cancer and a high ANA (antinuclear antibody) count? Thanks for any info.

d.

gma
Veteran Member


Date Joined Jul 2003
Total Posts : 2921
   Posted 7/13/2006 7:28 AM (GMT -6)   
I haven't a clue about this. Care to explain? I see you have been posting on other boards in Healingwell is it something discussed elsewhere? We are never too old to learn something. Hugs MK


Frayda
Regular Member


Date Joined Aug 2003
Total Posts : 248
   Posted 7/13/2006 7:56 AM (GMT -6)   

Hi! I am quite familiar with the antinuclear antibody count (ANA). It is a non-specific test that is used as an indicator for certain auto-immune diseases such as rheumatoid arthritis and lupus (and others).  I have RA.  As far as I know there is no direct correlation between ANA and cancer, but I have read that there is suspision that certain autoimmune diseases have a predisposition to some cancers and is under investigation.  If you took an informal survey among us bc friends, I think you'd find a surprising number with an assortment autoimmune diseases (RA, lupus, IBS, Chron's, etc).  Frayda


gma
Veteran Member


Date Joined Jul 2003
Total Posts : 2921
   Posted 7/13/2006 12:05 PM (GMT -6)   
Thanks Frayda, that explains a lot. djoyv posts on the lupus board. And I agree with you that auto immune problems seem to be related with cancers. You always have good information for us!!! Hugs MK


djoyg
Regular Member


Date Joined Jul 2006
Total Posts : 139
   Posted 7/13/2006 7:53 PM (GMT -6)   
Well, here's my story...it's a long one...so I'm goin to try to cut it down to the abridged version!
I'd been told I had Lupus and Hashimoto's thyroiditis going back 13 years, but I honestly never really believed the Lupus diagnosis. My ana's were never remarkably high. 1:40. 1:80. In more recent years my excellent rheumatologist has theorized that all I've ever had was the hashimoto's.

Breast cancer is heavily in my family. Including a great grandfather with a double mastectomy. I've already had 2 breast biopsies, melanoma 2x, basal cell and a very small squamous cell. I am also currently in the impossible situation currently of having tumors growing 'where they are not supposed to grow', and have not been able to find any doctor willing to oversee my care. I have at least 2 tumors embedded through the nerve roots where they meet the spinal cord on the left side at C7/T1 and T1/T2 and possibly a 3rd at C6/C7. There is a mass in the corresponding brachial plexus, which doesn't show up on a mammogram. The lymph nodes under my arm are swollen and tender. I have lost all reflexes in my left arm, function, strength, size and muscle tone. The outside body temp should be at minimum 95 degrees, my left arm is usually between 75 and 81 due to decreased blood flow. The only doctor that has even been attempting to coordinate any care has been my rheumatologist, who was recently shocked when my bloodwork showed my ana's were at 1:640. No one will even attempt to biopsy the tumors, but they do take up the enhancement. She can not explain the ana's because all other bloodwork appears normal and there doesn't appear to be any immune process going on.
Then I entered high ana's and cancer into a google search and a bunch of papers came back. All stating that basically this is how researchers are trying to develop blood test screenings for cancer (breast and lung primarily) That people with an immune process with have ana's in a certain range, and people with cancer will have ana's in a high range which can thus make it useful for a 'blood test diagnosis'. This is what led me to think of asking if anyone of you had heard if you had high ana's.

If anyone has heard of an amazing neurosurgeon willing to operate or even consult with someone that has tumors 'in the wrong place', please let me know! I will travel and my insurance will pay for me too go anywhere!

Thanks,

d.

Brnadebt
Veteran Member


Date Joined Jul 2005
Total Posts : 688
   Posted 7/13/2006 8:59 PM (GMT -6)   
Hi D
 
Iam one of the women with an autoimune disease called Sarcoidosis, I don't know if you have heard of it or not. My ANA's are high too because of the sarcoidosis. There is alot of research showing that autoimune diseases have alot more people who are eventually diagnosed with cancer too. I think it is something that you have to keep an eye on. I have nodules (small tumors) in my lungs, liver and spleen. It sounds like you could really use a biopsy to determine what you really have. It sounds alot like Sarcoidosis but alot of Drs have never worked with anyone that has the disease so they do not do tests for it. I got lucky my Dr is on a national list for specialist in Sarcoidosis (I live in the Seattle area) so I was able to be diagnosed fairly quickly. Rheumatoid arthritis goes hand and hand with my disease too.
 
 
If you have any questions e-mail me and I will be happy to talk to you about it.
Bernadette

sschmidt
New Member


Date Joined Mar 2008
Total Posts : 1
   Posted 3/18/2008 4:43 PM (GMT -6)   
I am not sure if these two things in my life are related but....
 
For many eyars I ahd a high ANA titer.  Doctors thought I had lupus but.....after I was treated for breast cancer with chemo and radiation my ANA was normal.  Are they related?  I wonder.

sasha1
New Member


Date Joined Mar 2008
Total Posts : 13
   Posted 3/19/2008 9:55 PM (GMT -6)   
i have crohns disease and live in georgia my local doctor sent me to jacksonville fla to the mayo clinic so far i have had nothing but good results when i first went they put me through all kinds of tests at first i wondered why they was sending me to all the different doctors they treat your whole body and the good thing they dont rush you out of the office like some doctors all the doctors are in the same building so it makes it convenient they have a wide range of doctors and they cummunicate with the other mayo clinics on there patients when i first went some days i would have to see up to 5 or 6 doctors and i would only have to pay one office copayment so this was good there is also a place you can stay real cheep and if you cant pay all you have to do is tell them this has to be set up with the counslor at the clinic but they have hotels that give a mayo clinic discount i have stayed at both if you want any more info my e-mail is freenine04@yahoo.com
sasha1

gjt
New Member


Date Joined May 2008
Total Posts : 2
   Posted 5/11/2008 12:21 PM (GMT -6)   
Can anyone tell me if a 1:80 ANA titer test, speckled pattern, my dr advised as positive - is HIGH result?

Lmmackey
Regular Member


Date Joined Mar 2005
Total Posts : 316
   Posted 5/12/2008 9:42 AM (GMT -6)   
Hi d.

Tarlov cysts, of which I have, generally appear in the Sacrum but also are "untouchable" by most physicians. However, Dr. Donlin Long at Johns Hopkins is world-renowned for his work on spinal tumors.

Also, Frank Feigenbaum http://frankfeigenbaum.com/practice/.

I hope you get some answers soon!

My prayers are with you!

Lauré
The finger of God touches your life when you make a friend.
----Mary Dawson Hughes---


djoyg
Regular Member


Date Joined Jul 2006
Total Posts : 139
   Posted 6/8/2008 11:17 PM (GMT -6)   
Hi gjt:

1:80 is an elevated ana result, but it is not really high. Anything less than 1:40 is within normal range. From there, the figure doubles every time it increases (1:80, 1:160, 1:320, etc.) some studies have shown that a range of 1:40 or 1:80 is normal in an older individual. Oddly, when a person's spouse/partner has a condition that involves a positive ana, that person often times also experiences a mildly positive ana in the 1:40 to 1:80 range.

I hope this information has been helpful,
d.


djoyg
Regular Member


Date Joined Jul 2006
Total Posts : 139
   Posted 6/9/2008 12:06 AM (GMT -6)   
Hi Lauré:

So kind of you to respond, so long after my original post, I've decided to take a moment to update. There came a point when I had become completely frustrated with "medicine". I had been unable to find any doctor able to help other then with pain meds and nerve desensitization meds. I woke up one day and said to myself, that's it! I've had enough with doctors, appointments and bs! I had been seeing a doctor at UCLA that was from Tibet, he was involved in a research project attempting to show that traditional Tibetan methods worked, proving them with the assistance of Western methods---eegs, computers, etc. I continued to see him, until his project ended, but that was it. I went to a bookstore and bought a bunch of books. I had heard about Dr. Paul Pearsall, who believed that lots of good sex cured him of his fatal cancer. I decided he was possibly onto something and that was what was missing in my life. I set about to try to meet a willing 'victim'! I dated for awhile, and then finally met my boyfriend (we are still together). I have 4 sons and an ex-husband, but sadly and honestly, he was never good in that department and I never felt that I could say anything. Starting a new relationship and moving forward with my 'plan', meant I got to know him for awhile before becoming intimate, made a promise to myself to be forthright and honest, crossed my fingers and hoped for the best! Well, things went great from the start, and before long I went completely off all meds! Which is really quite shocking. I had lost some use of my left arm and I noticed this returning. I had been unable to go for walks without a cane---I walk my dogs 2, 3 times a day now, I never use my cane anymore. I could sleep in a bed again. After about a year, I noticed some of the pain worsening and I became worried. It had now been 2 years since my last MRI. I went to my endocrinologist to have my thyroid bloodwork done, and she insisted I have one and wrote the order. I went to UCLA, where all my previous MRIs had been done, for accuracy.

The tumors were gone. The radiologist referenced my most current 3 MRIs done there that had shown the tumors and the various changes between each MRI and noted that he could provide no explanation for their disappearance. My endocrinologist theorized that it is residual nerve damage that was causing the increase in pain and that I may always experience that or I may eventually overcome it. She talked me into restarting a couple of the nerve desensitization meds, at low doses.

By and large, I have been feeling really good. A few months ago I went to UCLA to see a different doctor I hadn't seen in a long time and I had forgotten that she didn't know about the tumors 'disappearing'. When she asked about them and told her they were gone, she refused to believe it. She left the room, came back with the Radiologist's report & a copy of the MRI and in a shocked voice said, "They're gone. I can't believe it. I have to show this to my head of department." I was like, "That's what I told you. They're gone. I can't believe you didn't believe me!"

My ana's are still highly elevated and I am currently going through some skin cancer issues. I had melanoma a couple of times in the past, 15 years ago & 12 years ago, as well as 1 small squamous cell 13 years ago & a basal cell 4 years ago. A couple of months ago I had a marble shaped squamous cell tumor removed from the back of my head where it meets my neck, last month I had a more superficial sqamous cell patch removed from my scalp from where it had started to spread. I am now going through a topical chemotherapy treatment. I am awaiting the results of a biopsy of my left shin, which looks as if it could be another melanoma.

Someone else mentioned that their ana's went back to normal once they were cancer free. I wonder if this will be the case for me as well. I haven't always had elevated ana's. I wonder now, if I look through my chart, if my ana's have been down at the times when I had no cancers/tumors.

Thank you, Lauré, for your well wishes. I wish everyone else the best as well.
d.


Aryana70
New Member


Date Joined Apr 2010
Total Posts : 1
   Posted 4/26/2010 8:50 AM (GMT -6)   
Hi Everyone,

I recently had blood tests done, and everything was fine, except my liver function was up slightly and kidney function was down. But my ANA count was a concern from my doctor, it came back 2560.....I dont know what that means he is sending me to a rheumatologist for more testing. All the bloods for lupus, arthritis all came back negative. So i'm not to sure how i should react and if there is anything to really worry about. I've just turned 40, I have aches and pains, headaches, and i'm tired all the time, would this tie in with the high ANA

cheers

Mama B
New Member


Date Joined May 2010
Total Posts : 1
   Posted 5/14/2010 11:36 PM (GMT -6)   
I am a 56 year old woman whose main complain was fatigue, muscle weakness and just generally feeling "not right". I have positive ANA 1:2560, homogeneous. All follow up tests show negative for Lupus, scleroderma, sarcoid, myositis. I have elevated CPK, approx 336. Mildly elevated CRP. Last week I had a muscle biopsy from my thigh. Don't have results from that. Dr mentioned just sitting back and monitoring symptoms. I have been having tests since September. Any input? Thanks!

mumsyluv
New Member


Date Joined Oct 2010
Total Posts : 1
   Posted 10/11/2010 6:58 AM (GMT -6)   

Hi, can someone please help advise me as I’m very unwell. I’ve been extremely tired for the last 6/7 month and have a swelling in my neck...no lump however I feel like my lymph nodes are swollen when press down. I've been anemic for which I was given tablets and after few months I felt like I was back to the start feeling so ill I insisted on my doctor referring me to Bupa  as my doctors were simply giving me anti depression tablets. I eventually have been referred and am anemic as well as having a very high ANA. I have lost tons of hair in bunches, feel absolutely awful, very weak and feel as though I’m pulled down, drained.

 

My doc has put me on lupus tabs but I really believe it's not that as all other lupus tests were negative, he also told me to come back in 2 weeks if it didn’t make any difference. Can someone tell me what I should do? My neck inside hurts and is bigger on my right side, I also have swelling on my right arm.

 
 
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