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ReactiveConstellationNE
Regular Member


Date Joined Dec 2005
Total Posts : 256
   Posted 4/30/2008 11:14 AM (GMT -7)   
in my experience, and based on my in depth knowledge of pharmacology/organic chemistry, Oxymorphone (Opana) is far superior to Oxycodone and almost every other opiate except possibly for Fentanyl. There is some debate as to whether Hydromorphone (Dilaudid) or Oxymorphone is superior but I would much rather have a Morphone than a Codone, personally.

I wouldn't expect an improvement from Oxycontin over Opana ER. I hate to say it, but if you weren't getting enough from Opana you either need a higher dose, or you may find that you have the same if not worse problems with other opiates.....
Conditions: Reactive Arthralgia/Reactive Constellation, Chronic Pelvic Pain Syndrome, Sacroiliitis, Costochondritis, widespread Tendonitis, severe back pain & spasms with numerous spinal problems, barely able to type anymore due to severe full-body runaway inflammation, and on and on. Typical daily pain levels exceed 8.5(!)

Medications: Methadone, Dilaudid, Oxycodone, Marinol, Cesamet, Lidocaine Patches, Flexeril, Zanaflex, Soma, Desipramine; many herbs & supplements.


Previous medications: Oxycontin, Opana, Fentanyl patches, Kadian, Avinza, MS Contin, Lortab, OxyIR, Baclofen, Testosterone (oral, patches, gel), Cymbalta, Lyrica, Neurontin, Amitryptyline, every NSAID known to man, Prednisone....and many, MANY more.


Disce Pati
Regular Member


Date Joined Apr 2008
Total Posts : 61
   Posted 4/30/2008 12:43 PM (GMT -7)   
ahh....but I think you forgot about pharmocogenetics: that is, how each person's genetic make-up influences his / her reactions to the pain meds based on opioid receptors (type and numbers available) and metabolic / catabolic enzymes that transforms the parent drug into the active metabolites (and other factors based on genetic make-up). In addition, there may be environmental issues that affect how the medication is absorbed and metabolized (diet, etc). And then there are the side effects that can make one medicine more or less effective in the individual........


There are most likely too many variables to say with so much certainty that one med is vastly superior to another for all people in all cases. There are too many times when intuitive "knowledge" is not borne out by empirical evidence. While, theoretically a person may be able to state that on a general scale opana may be a "stronger / more potent" narcotic than oxycodone and dilaudid when it comes down to the clinical application the only "fact" that is real is what the individual patient experiences.

Just my humble opinion for what it is worth.......

shannon1
Regular Member


Date Joined Feb 2005
Total Posts : 369
   Posted 5/1/2008 7:42 AM (GMT -7)   

I agree w/ Disce Pati,

I have taken percocet for years w/ pretty good response. I was switched to opana 2 x a day, and had horrible headaches/nausea. I took it for close to a week, and had ZERO pain relief from it.  I started back on my percs and am up and walking again! I think everyones body digests meds differently. If opana works great for you, im very happy that u have found something that take the edge off!!!!! That is all everyone here is looking for, i think! lol

good luck, shannon


blizzardlizzard
Regular Member


Date Joined Feb 2008
Total Posts : 23
   Posted 5/1/2008 1:00 PM (GMT -7)   
I'm on Opana too and I've had some great results from it. I guess everyone's different though. I hope everyone is having a lpd.
CRPS 1 in the right leg
Spinal Arthritis
Anxiety Disorder

One day at a time


ReactiveConstellationNE
Regular Member


Date Joined Dec 2005
Total Posts : 256
   Posted 5/2/2008 12:28 PM (GMT -7)   
absolutely. Having tried almost all the opiates/pain meds out there (including almost all of the classic "cop-out scripts" as I call them, like Cymbalta) I was just trying to share my perspective & experience for whatever it was worth.....Opana is great medicine, IMHO. Pretty much the best of the "traditional" opiates.

After the "traditional" opiate hierarchy, there are two other classes of opioid pain medicines:

1) Fentanyl family, which is so potent by weight that it is dosed in the micrograms rather than milligrams, and though it is very short-acting (about 2.5 hours), its receptor binding affinity is extremely high and cannot be blocked by other opiates -- even methadone tends to yield to Fentanyl, which is what makes the combination of methadone with Fentanyl as a breakthrough pain medication such an excellent one.

2) Opioids which are related to unique compounds such as DXM (dextromethorphan, the main ingredient in cough syrups, Nyquil/Dayquil etc) and which act via several routes other than just opiate receptor binding -- though they both have a very high binding affinity and tend to take priority over just about anything except possibly for Fentanyl-class molecules.....

These are:

-- 2a) Methadone ~ NMDA receptor antagonist, reuptake inhibitor for Serotonin, Norepinephrine, Dopamine, very long duration of action and often works where traditional opiates fail to control severe pain of certain types while helping to flatten out the tolerance curve over time to keep the medication working properly to control pain for much longer at a stable dosage than one could with other straight-up traditional opiates.

-- 2b) Levorphanol (Levo-Dromoran, an extremely close relative of DXM) ~ very potent NMDA antagonist, opiate receptor affinity nearly on par with Fentanyl and superior to that of virtually all others.....very well known to control pain that is insufficiently managed otherwise. 2mg dosage, lasts longer than any other non-time-released opiate except for Methadone -- an average of 5-7 hours instead of 4-6.
Conditions: Reactive Arthralgia/Reactive Constellation, Chronic Pelvic Pain Syndrome, Sacroiliitis, Costochondritis, widespread Tendonitis, severe back pain & spasms with numerous spinal problems, barely able to type anymore due to severe full-body runaway inflammation, and on and on. Typical daily pain levels exceed 8.5(!)

Medications: Methadone, Dilaudid, Oxycodone, Marinol, Cesamet, Lidocaine Patches, Flexeril, Zanaflex, Soma, Desipramine; many herbs & supplements.


Previous medications: Oxycontin, Opana, Fentanyl patches, Kadian, Avinza, MS Contin, Lortab, OxyIR, Baclofen, Testosterone (oral, patches, gel), Cymbalta, Lyrica, Neurontin, Amitryptyline, every NSAID known to man, Prednisone....and many, MANY more.

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