Ankylosing Spondalitis

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The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/20/2009 8:22 AM (GMT -7)   
Hi I am new here and I have Ankylosing Spondalitis, I have used all the TNF blockers. Has anyone gained diabieties from using TNF blockers? I was diagnosed about 5 years ago after seeing many doctors and after taking a lot of different pills which i am sure were just different types of asprin and even being told the pain was just in my head Finaly I found a doctor by accident as I was going to see another doctor in that surgery and when he thought I was putting it on he sent me to see an indian doctor, this guy told me the best news every even though it was not good, that I was not going mad an infact have a disease. I was almost at the point of giving in as I could not live with the pain I was feeling through my whole body, hips, middle back, neck, through my chest and stumack.  I was a wreck.  I was driving a taxi and when i would get home after my night shift I would not be able to pull myself up stairs as the pain in my hips was very bad and eventualy I had a mild Heart attack as the fluid was building around my heart and plurisy from fluid around my lungs.  So I gave our lease back for the taxi and went on government handout It distroyed my life.  After I found my new doctor he sent me to a ruematolagist and he after many tests placed me on embrel What a wonder drug after the first month my pain went from a ten to a three it was fantastic and after I had completed the test course my fluid and pain levels started to rise again so  the RT placed me on Remicade this made me feel very ill after four weeks the doctor ordered a stop on Remicade as my body was rejecting the protien my hair was falling out my skin was grey I felt like I was going to die but I recovered so then they placed me on Humira initialy it worked but after six months it also stopped working now I am on Salazapirin 3000mg, Naprosyn 1000mg, and PLaquinel for cramping Morphine 40mg morning and many othersNow I have a camicaly induced type 2 diabeties and high blood pressure and a form of epilepsy I am now wearing a neck brace.

Tony McGuire
Regular Member


Date Joined Feb 2009
Total Posts : 483
   Posted 4/20/2009 8:39 AM (GMT -7)   
.
First, welcome to HW. Never glad you need to be here, but since you do I'm glad you found us. Maybe we can be mutually beneficial, either soon or late.

To the reason for your post:

Chemically induced Diabetes? Never heard of that one, but it wouldn't be the first thing.

What other drugs? What do they say you have, exactly?

What are your questions, exactly?

Hopefully you can help us get to the bottom of this. My curiosity is certainly high at this point, since I have Diabetes as well as neuropathic pain from diabetes.
Wife: Liz, the choice of a lifetime
Dogs: Koshka Prayer & Chomp Prayer


Falling apart in TX
New Member


Date Joined Apr 2009
Total Posts : 15
   Posted 4/20/2009 9:51 AM (GMT -7)   
Chemically induced diabetes?

Yes.

Certain drugs can and often do cause diabetes. Dexamethazone, a steriod caused mine. It was given to me to reduce the swelling in my brain prior to a craniotomy to remove a tumor. Human growth hormone is another one that can cause it. I think most people have to be borderline in the first place, but not always. Just my 2 cents.

Post Edited (Falling apart in TX) : 4/20/2009 11:12:31 AM (GMT-6)


The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/20/2009 10:31 AM (GMT -7)   
Gaday TonyMcGuire,  I have ankylosing spondalitis, it is a severe form of arthritis which involves alot of conditions rolled into one, from sacriolic joint erosion to lower back and sacriolic fusion , back bone fusion in the mid region and also the neck and shoulder regoin. It can cause curvature of the spine into a forward motion or bending of the head towards the chest. All of my joints swell with fluid and I have pain in almost every part of my body all the time.  My doctor says that the disease is very aggressive and I am in stage 4 of which there is only one to four stages.  Had I have been diagnosed earlier I would of had a better chance of medications working for me.  I can not run any more sometimes on a good day I can manage a slow jog but only for about 100 metres.  I have had to change my whole life but am thankful I have a loving wife and son with me.  I should explain what happens to start off this disease your brain makes a fluid when you are sick which flows down you back bone which turns into antibodies when that proccess starts in me there is no way to stop it but to introduce a blocker to chemically induce this switch to turn it off.
 
Now as for my Questions.  I would be very interested in finding out whether anyone else after taking TNF blockers (which are the chemically induced switches or auto immune drugs) have found that they have diabeties? 
Do you know of any knew pain medications or herbal remadies which may help?
I know it must be rare because I can not find information about this yet my doctor has said this is what has caused it for I did not have a problem before taking the TNF blockers.
Do you know of any knew pain medications or herbal remadies which may help?
The doctor also thinks there may be another disease underlying that he has not found yet in my system causing certain medication not to working any advice would be appreciated. 
 
My medications are Salazopyrin 3000mg, plaquinal 100mg, morphine 40mg,coversyl 10mg,diaformin sr 3000mg, actrapid injection sliding scale, lantos solostar 16 units,epalim 400mg, omeprazol 20mg, amlodipine 5mg and panadien forte when needed.  I have a few other issues as well but will discuss them all in time thanks.  Its good to be able to talk about these issues with others when I talk to most doctors I end up educating them about my problem. thanks for listening look forward to gaining some answers in time.

Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 4/20/2009 10:33 AM (GMT -7)   
I know a lot of the AS people post on the arthritis site...I have Crohn's , so I know a bit about AS and the TNF blockers...In my research, I have not seen that the TNF blockers have caused any type of sugar sensitivities. However, what other meds have you taken to control it? Prednisone, budesonide, or any of its buddies? Even 1 year or so later, they have been known to act up...I gotta watch the sugars myself...
What other meds do you take for your AS? How are you doing with it? Are you totally fused? (I have issues as well in the illeosacral joint due to my crohn's)...I understand how painful it can be...welcome...but I wish for you, and for all of us, a lesser pain day...
"The earth laughs in flowers"


The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/20/2009 10:41 AM (GMT -7)   
Thanks everyone the doctor also thinks i may have chohn's as well because of other symptoms I have had latley but he has not done any tests for this so far and after reading I found that severe AS patients can also get Crohn's. I pray not!!!

The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/20/2009 10:43 AM (GMT -7)   
Thanks everyone the doctor also thinks i may have chohn's as well because of other symptoms I have had latley but he has not done any tests for this so far and after reading I found that severe AS patients can also get Crohn's. I pray not!!! No I am not fused yet mabey because I was Fairly strong in my youth doing martial arts and staying active

Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 4/20/2009 11:12 AM (GMT -7)   
Yuppers gotta watch my back...just saw a Rheumy for the first time. It looks mostly like Rheumatoid like inflammation, but they are seriously watching for the AS.

How long have you been on the immunomodulators? I have been on them for about 2 years...no issues. However, just a little increase on the prednisone, and the sugars go up.

I was really active as well (I've run marathons...completed 4 and too many other 1/2 and under to count). I've found that the elliptical machine (when I can unfurl myself from the bed) to be a nice work out and not so hard on the joints or bum...I even used this 4 days post op from my bum surgery. I could do this even when I could not walk on a treadmill or sit(that bum thing) on a bicycle.

As for the pain thing...I've found that the patch thing works the best...other people with digestive issues have found this works as well...and it works for all the different types of pain. I see a Pain Specialist.
I do take many vitamins...especially calcium...oh and now that I'm on sulfasalazine, I make sure and get my folate.
"The earth laughs in flowers"


Pamela Neckpain
Veteran Member


Date Joined May 2008
Total Posts : 1821
   Posted 4/20/2009 11:28 AM (GMT -7)   
,

Another holy man amongst us?

I have been diagnosed with Anklyosing Spondylitis. Several Doctors: shocked

I didn't know what it was/is.

I have to go lay down. Pain again.

I'll be back to talk with you a little later. I hope. shakehead

This ain't for sissies.

Pamela shocked

Post Edited (Pamela Neckpain) : 4/20/2009 12:34:43 PM (GMT-6)


uniquelyme
Veteran Member


Date Joined Nov 2008
Total Posts : 1037
   Posted 4/20/2009 12:13 PM (GMT -7)   
Pamela, you need to get voice activated typing on ur computer...then you only have to talk and it does the rest...I think we all need it...Hope you feel better friend..

Me.
 
We are all in the same boat...unfortunatley it seems like it's sinking...
Post Lamenectomy Syndrome
Hemi Lamenectomy/Spinal Fusion(Lumbar)
60 mg. MS Contin 2Xdaily/15 mg. Oxycodone as needed
High Blood Pressure: Lisinopril HCTZ 10 mg. daily
Type 2Diabetes: (March 16, 2009)
Metformin 1000mg. twice daily (so far)
ME. (Rhonda)                                                                    

 


Pamela Neckpain
Veteran Member


Date Joined May 2008
Total Posts : 1821
   Posted 4/20/2009 12:30 PM (GMT -7)   
yes,

I have tons of research. I don't like the flimsly feel of lap top.

I think that I have to tap my fingers to be able to think. (It's an attention deficit
thing)

I'll look at them.

Wonder if I could pass the hat? Wonder if a heart would bleed and send me $$$.
I don't think so. I'm not "nice" enough. You know what I mean? I've never been
a weeper or an ego stroker. What about you, kid?

Post Edited (Pamela Neckpain) : 4/20/2009 1:33:34 PM (GMT-6)


Tony McGuire
Regular Member


Date Joined Feb 2009
Total Posts : 483
   Posted 4/20/2009 5:16 PM (GMT -7)   
Sorry, I thought you meant that the Diabetes was induced by drugs ON PURPOSE. I couldn't think of ANY reason to do that. Thank you for the in-depth info.
Wife: Liz, the choice of a lifetime
Dogs: Koshka Prayer & Chomp Prayer


Pamela Neckpain
Veteran Member


Date Joined May 2008
Total Posts : 1821
   Posted 4/20/2009 5:55 PM (GMT -7)   
Reverend,

You wrote, "The brain makes a fluid then you are sick which flows down
your back bone and turns into antibodies."

I have not yet studied Anklyosing Spondylitis. I like to get information
from "Real People" like on the forums. I do additional research.

When I started having all this back & neck trouble, I had just
suffered from an incident which caused PTSD. (7 years ago)
I have heard that sometimes
llnesses start from an emotional or physical trauma. (Even Cancer
and tooth decay!)

Could it be that after my trauma, the brain made antibodies?

I know nothing of your illness -- just know that I've seen Anklyosing
Spondylitis written on many of my doctor forms.

This post may not make good sense. If not, please disregard. I'll
come back and re-post when I'm smarter.

Pamela confused

Pamela Neckpain
Veteran Member


Date Joined May 2008
Total Posts : 1821
   Posted 4/20/2009 6:03 PM (GMT -7)   
Becoming Undone or anyone ...

All my life, I've been extremely active. No marathons BUT I could almost run two miles. I did a lot of
aerobic dance (2 hours almost daily) I lifted a lot of babies.

I admired a Tee shirt that read "MOVE MOVE MOVE MOVE."

I religiously studied health books and followed them - whatever was the fad at the time. I thought I'd go
to my older age in wonderful shape.

Well, it didn't work.

What do you think of lots of exercise?

Pamela
MEDICAL CONDITIONS

Osteoarthritis all levels of spine right down to Coccyx,Spondilytis,Myofascial Pain
Fibromyalgia,Bulging Discs,Spinal Stenosis,Scoliosis,Osteopenia,Chronic Constipation
Carpel Tunel Syndrome, Attention Deficit Disorder,
Depression & Anxiety

Methadone for Pain, Xanax for Anxiety, and more, of course.


Tony McGuire
Regular Member


Date Joined Feb 2009
Total Posts : 483
   Posted 4/20/2009 6:16 PM (GMT -7)   
I think exercise is like alcohol. A little bit here and a little bit there probably won't hurt you too much.
Wife: Liz, the choice of a lifetime
Dogs: Koshka Prayer & Chomp Prayer


Pamela Neckpain
Veteran Member


Date Joined May 2008
Total Posts : 1821
   Posted 4/20/2009 6:35 PM (GMT -7)   
I would make this a thread, Tony, but I'm not sure it's accurate. I can't find
Angel8's post regarding this information. Gotta get that printer going.

Angel said be sure and have a card in your wallet or on you that says you are taking
Methadone and also the amount. Call Medi-alert tomorrow and tell them.

Also you should have information that reads "No Namorphone, No Stadol, No
Sub X, No Narcan. If you should pass out from one reason or another medics
will read this and not give it to you. Apparently it's routine to give these meds
because they think it's an overdose. If they give you a shot of say, Narcan, in
about 2 minutes it will flood your system and take out ALL the Methadone and
put you into withdrawels. You could die if they don't figure out that you're not
an OD. You could die quick.

I could not find Angel's post and I'm kinda guessing at these medications. I
don't want anyone to take what I say seriously. Just have an awareness and
do your own research. I have no training in medicine or medical procedures.

I have gone so far as to write my medications on my stomach with a sharpie
permanent market.

We gotta know what's going on with us. Medical people can miss stuff. They
surrrrrrrrre have on me. The printing looks weird when I wear a bare midriff top -
verrrrrry strange tatoo.

Pamela smilewinkgrin

The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/20/2009 7:09 PM (GMT -7)   
G'day mates,  The brain makes a fluid which turns into antibodies when you are sick and we are supposed to have a switch to turn it off when we are better, AS is thought to be a hereditary disease so I have not heard of anyone gaining it from an accident but mabey you already had this condition and it prolonged your healing.
Exersice is good because the day you give up is the day it will get you, I am limited in what I can do and some days I do feel like staying in bed and letting the whole world pass me by but I know if I did it would take me a week to get over it because the pain sets in.  You must do some exersice I walk around the block and my wife walks with me to make sure I don't fall over as the pain and stiffness in my lower back causes me to lose balance and swimming is also very good because it takes the wait of your joints while you exercise.  The most important thing is to take it at your own speed and don't push it.  My doctor is more worried about me hurting myself from the exercise as I get worse and if you don't move you will be prone to blood clots and after having 2 shots of claxain in my stomach when doc thought I had a clot IT HURTS!!!, lucky no clots.
Yes I am a Holy man. I Pastor a church which is about as phisical a job as I can do these days.  By having your life shortened by a disease really opens your eyes to the smallest things.  Depression is another part of my illness that I must constantly address and be careful not to let it take over, there are days when all I want to do is close myself away from the world and sometimes we need that to get our minds clear from all the junk of the medication and ongoing barrage of tests we go through.  The hope is that the world is getting smarter and new medications are coming out all the time so it will not be long before we have some releaf.  Positive thinking and Positive People do help.
It is hard to soar like an eagle when your surrounded by turkeys. smilewinkgrin

angel8
Regular Member


Date Joined Apr 2009
Total Posts : 109
   Posted 4/21/2009 3:30 AM (GMT -7)   

Welcome to you Reverend you have came to a great place here.

I also have AS but not into a full stage 2 as of yet. It is a hideous disease in itself and many times it goes untreated,undiagnosed,and even misdiagnosed until we are much farther gone then should be.

I also have found there is NOT alot of info out there and far too many Docs recognize the term but also dont have alot of info for you.

I do have the lung and breathing thing associated with AS but since I am a smoker for years most Docs just blew that off and yes it was one of the first indications for me that something was wrong other then the low back pain and sciatica in my left leg.

I cannot answer your questions regarding the auto-immune drugs as I have choosen not to go that route just yet due to the mass amount of complicating factors involved in maintainig on those drugs as well as I would have to change alot of my meds that are working for me.

I do know that there is many drugs that can lead to diabetes though.

Glad to see you found a place to come to and you sure wont lack folks who understand pain here.

Pamela I will try to find the post I made but you have pretty much got them down,any of the opiate antagonists such as NArcan,stadol.numorphone,talwin and yes now sub-x, my medicalert simply say says no NARCAN and they know from there what is happening. I hope anyway!LOl

The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/21/2009 5:09 AM (GMT -7)   
G'day mates from down under, thanks for your welcome and look forward to finding some answers and hope that i may be able to help others as well with AS i will look up some info on AS and post links if possible. I do understand concerns with taking TNF blockers and their side affects, i had to way up the issues as well and i was a smoker until 7 months ago the cancer aspect was the most worrying as it does increase your chances of getting cancer if this is an issue you should attend some form of councelling with doctor and your partener if you have one because when the pain intensifies and becomes debilatating you will need to look at these drugs, a lady who also goes to my RT is refusing pain management drugs of any sought and I see her every time I attend and can see the pain and discumfort she is in and I know what relief I got from them they do work for a while and others have had great results on them. Each to their own though. See ya mates.

The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/21/2009 9:08 AM (GMT -7)   

Hi everyone, having a slow cold stiff night with lots of cramps, just the usual really. I like your ideas on the medi alert thing for meds you should not be given and I am going to ask my doctor for more info about the meds that i take and what should not be taken with them and keep a record on me, well maybe not writen on me though.  thanks.

I have found that I can not use the skin patches for medication as I get skin irratations from the sticky stuff, so I guess I have to stay with the pills for now. rolleyes

Question, does anyone do tai chi exercises for help with AS or Ruematoid?  and can you still stretch enough to do it?  The more exersice I do I get Sorer.


The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/21/2009 9:19 AM (GMT -7)   
to becoming undone I was on Tnf blockers for about 2 years and in some cases if you are diagnosed early they can help by removing the fluid which causes most of the problem and if you can do this you can stop the damage to your body so you can live a long and comfortable life without the early onset of deformaties. There is hope.

Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 4/21/2009 9:25 AM (GMT -7)   
What TNF are you on? (me: Remicade for 1.5 yrs...Humira for 2 months...now on Cimzia...) These have helped my seemingly Non crohn's problems such as migraine (remicade worked better for this), and joint issues...As to the cancer issues...I worry more about what the disease is doing to my liver and stomach cancer (my grandmother passed from that and Oh I have quite a few polyps in the stomach and esophagus)...I want my disease under control first...

Again, if you can...see a Pain Specialist...he/she might have therapies that work well for you. You may even even be worthwhile to try different brands of patches (each has it's own "special formula" for adhesive) and you may react less to one than another.

I do try and stay flexible. I stretch often but in short burst...like just getting up and stretching the arms or legs...not as part of a huge exercise routine . I feel my joints stiffen...I've read and my docs have said, that you do need to move them...within reason of course. Don't do anything that hurts too much...I do some yoga...when I can...but gentle stretching (ala Whinney the Pooh: up down touch the ground...) works very well for me...

Pam: I love what working out does to clear my head and gives me all those feel good things(gotta love that runner's high)...just hate that it can make so much of me feel horrid(joints and tummy pain and GI issues)...
"The earth laughs in flowers"


The Reverend
Regular Member


Date Joined Apr 2009
Total Posts : 66
   Posted 4/21/2009 9:47 AM (GMT -7)   
I was on enbrel injections remicaide infusions and the last one was Humira injection my body rejected them all so now I am back on tablets. The best was enbrel I could realy feel it work.
Thanks about the patches I did not know they had different formulas for adhesives I'll look around

My father died of cancer at a young age so that is why I think I struggled with that question when I started on TNFs
Well still breathing its all on the up and up, catch ya on the flip side, see ya mate
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