Question of why would clarithromycin potentially interact with fentanyl patch?

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veromia333
Veteran Member


Date Joined Mar 2009
Total Posts : 674
   Posted 10/20/2009 3:12 PM (GMT -7)   
I have to take Clarithromycin (a mocrolide antibiotic) because I have Lyme disease. I had one bad experience at a pain clinic now i am going to another one as my family doc is sending me.
I am trieing to educate myself on what i can take. i notice that it says Fentanyl patch is a potential interaction w clarithromycin, discuss it with your doc. it doesnt really say why?

Wondered if anyone here knows.
The line is faded not showing where Lyme came in. I became a new Mommy n my Lyme decided to show itself. Swollen elephant like knee and finger and limiting back pain. Bell's palsey, weight loss as if I had no muscle on my bones anymore. And much more text book lyme symptoms. To a Lyme doc, after alot of there is nothing wrong with you and a recommend to counceling,he said V this is Lyme. What kept me pressing on I had Lyme while I was pregnant. I know I was not infected while pregnant. I am watching her with an eagle eye. God Bless everyone. Love Veronica. Were the ones who know about Lyme not the doctors. Isnt that just mad? Backwards. Alice in wonderland.


Chartreux
Veteran Member


Date Joined Aug 2006
Total Posts : 9622
   Posted 10/20/2009 3:31 PM (GMT -7)   
A Pharmacist might know the answer so ask or even call your doctor before taking either meds together...
it's good you caught this..
Hope this info helps...
hugz
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veromia333
Veteran Member


Date Joined Mar 2009
Total Posts : 674
   Posted 10/20/2009 5:53 PM (GMT -7)   
Thanks
The line is faded not showing where Lyme came in. I became a new Mommy n my Lyme decided to show itself. Swollen elephant like knee and finger and limiting back pain. Bell's palsey, weight loss as if I had no muscle on my bones anymore. And much more text book lyme symptoms. To a Lyme doc, after alot of there is nothing wrong with you and a recommend to counceling,he said V this is Lyme. What kept me pressing on I had Lyme while I was pregnant. I know I was not infected while pregnant. I am watching her with an eagle eye. God Bless everyone. Love Veronica. Were the ones who know about Lyme not the doctors. Isnt that just mad? Backwards. Alice in wonderland.


BionicWoman
Regular Member


Date Joined Jul 2008
Total Posts : 243
   Posted 10/21/2009 12:39 PM (GMT -7)   
Microlide antibiotics are cytochrome P450 3A4 inhibitors. The antibiotic causes your body to filter the Fentanyl out more slowly, but since you're still putting it in at the same rate, it builds up in your blood and causes you to overdose. Since it normally takes about 17 hours from the time you take the patch off until the medication in your skin is completely processed, you can't/don't stop the "overdose" by just taking the patch off when you become aware of the symptoms.
The difference between perseverance and obstinacy is that one comes from a strong will, and the other from a strong won't. ~Henry Ward Beecher

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