New drug for pain management

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keep the faith
Regular Member


Date Joined Nov 2009
Total Posts : 91
   Posted 3/4/2010 12:56 PM (GMT -7)   
Just read this announcement and thought I'd share it with the group.
 
Covidien today announced that the FDA has approved the New Drug Application for EXALGO, hydromorphone Extended-Release Tablets.

The indication for EXALGO is once daily administration for the management of moderate to severe pain in opioid-tolerant patients requiring continuous, around-the-clock opioid analgesia for an extended period of time.

The launch of EXALGO tablets, which Covidien anticipates in the first half of calendar year 2010, will include a comprehensive Risk Evaluation and Mitigation Strategy (REMS) that is designed to ensure that the benefits of EXALGO outweigh the potential risks.

The drug will be offered through Mallinckrodt, a subsidiary of Covidien.


IsThereAnEnd?
Regular Member


Date Joined Feb 2010
Total Posts : 66
   Posted 3/4/2010 1:17 PM (GMT -7)   
Interesting.....great information, keep the faith ~ I am always hoping something new and life changing comes out for us CP'ers ~ wouldn't it be nice to take one pill daily? :) Love that idea!

Hope you are having a tolerable-pain day ~

Huugggsss!
Cardiomyopathy, Celiac Disease, High Blood Pressure, 2 Fusions @ L4, L5, S1, 2 Fusions @ C7 & C8, Implantible bone growth stimulator cervically, and soon to have Neurostimulation Therapy to treat lumbar, Chronic Pain Sufferer for 8 years, take several meds daily to survive! Looking for a miracle I think ~


Chutz
Veteran Member


Date Joined Jan 2005
Total Posts : 9090
   Posted 3/4/2010 4:09 PM (GMT -7)   
Thought I'd do some research on this medication so we all know what it is and what it is NOT. wink

Exalgo = Hydromorphone

"Hydromorphone, a more common synonym for dihydromorphinone and dimorphone, commonly a hydrochloride (trade names Palladone, Palladone SR, Dilaudid and numerous others) is a potent centrally-acting analgesic drug of the opioid class. It is a derivative of morphine, specifically a hydrogenated ketone thereof and therefore a semi-synthetic drug. It is both medically an opioid analgesic and legally a narcotic. It should not be confused with hydromorphinol, also known as 14-hydroxydihydromorphine and RAM-320 nor dihydromorphine (Paramorfan). While all of these are strong opioids, they are indeed different drugs. Additional confusion arises from the fact that in a handful of countries hydromorphinol is distributed under the trade name Numorphan, which is the trade name for oxymorphone in the rest of the world according to the current version of The A-Z Encyclopaedia of Alcohol & Drug Abuse and other references."

There will be a lot of restrictions on the dispensing of this medication so for most people it won't be as easy as getting a prescription from you doctor, filling it at the pharmacy and taking it. You will have to enroll in their program, pharmacies will go through training as will the doctors. Here's a link to more information on that topic.
updates.pain-topics.org/2009/09/new-opioid-exalgo-on-slippery-slope-of.html.

A couple of sad things I noticed were... some bloggers are happy since alcoholic beverages don't seem to have an effect on this medications. But more disturbing for me was that at least 95% of the articles online deal with the money side of this medication and very little with what it can do to help people with chronic pain.

I do hope this information helps but more than that I hope this medication comes through for those in need of pain relief and not with so many restrictions that it's impossible to get and use.

Chutz
"Knowledge is knowing that a tomato is a fruit, but Wisdom is knowing not to put it in a fruit salad."

(\_/)
(o.o)
(> <) Co-Moderator Fibromyalgia & Chronic Pain Forums
Fibromyalgia, PTSD, UC, Diabetic on insulin, collapsed disk, arthritis scattered around and a few other delights.


skeye
Veteran Member


Date Joined Mar 2008
Total Posts : 2976
   Posted 3/4/2010 4:12 PM (GMT -7)   
Very interesting, thanks for sharing. I take hydromorphone, so I'll have to keep an eye on this.

Skeye

Hound-Dog
Regular Member


Date Joined Oct 2005
Total Posts : 183
   Posted 3/4/2010 5:21 PM (GMT -7)   
Hydromorphone caused my breathing to slow down way too much for the amount of pain relief I was receiving.I was only on it for three days before my Dr. switched me back to morphine which has worked well for over ten years.That REM program looks like a real problem for Americans if it becomes standard practice for all opioid prescriptions.Like chronic pain patients need any more hassles than we already have......Not.

Chutz
Veteran Member


Date Joined Jan 2005
Total Posts : 9090
   Posted 3/4/2010 5:35 PM (GMT -7)   
Thanks for your input, Hound-Dog! This is the one way we know how effective and safe any medications are, but sharing our experiences. As with all medications, they work for some people and are a nightmare for others. But having new and different ones available makes it more possible that we can find one that works for each of us.

Chutz
"Knowledge is knowing that a tomato is a fruit, but Wisdom is knowing not to put it in a fruit salad."

(\_/)
(o.o)
(> <) Co-Moderator Fibromyalgia & Chronic Pain Forums
Fibromyalgia, PTSD, UC, Diabetic on insulin, collapsed disk, arthritis scattered around and a few other delights.


Stella Marie
Veteran Member


Date Joined May 2005
Total Posts : 601
   Posted 3/5/2010 3:39 AM (GMT -7)   
Thanks for the research Chutz. This type of information is vital when we make drug decisions. Some doctors listen to sales reps and get over inthused about potential new drugs or reformulated old ones in new dressings. It is always good to understand the medication you are taking.

Stella Marie 

Chronic Pain Forum Moderator

Progressive neurodegenerative disease called Multiple System Atroph;  muscle spasms, muscle pain, neuropathy  & neuropathic pain, central sleep apnea, osteoarthritis, and 2 pain implants – an  intrathecal pain medication pump and an SCS (spinal cord stimulator).  Extra fun little toys and gadgets; O2 generator and assorted wheelchairs, walkers, canes, and orthotic braces.  Meds - too many too list or even care about!

 

 



Retired Mom
Veteran Member


Date Joined Feb 2010
Total Posts : 1753
   Posted 3/5/2010 8:05 AM (GMT -7)   
Hydromorphone works wonderfully for me, but oxymorphone (opana) does not. I wonder if this med is more like the oxymorphone or the hydromorphone of today. Hydromorphone is cheap to fill, but oxymorphone is very expensive for me.
DDD, CPS, TLIF L5-S1 2009 (failed), FIBRO, MINEYER'S (SP?), MIGRAINES, GERD, NISSEN FUNDOPLICATION (failed), GAD, DEPRESSION, EXTREME ANXIETY DISORDER, OCD, PSTD, CHRONIC MUSCLE SPASMS, HUMAN GROWTH HORMONE DEFICIENCY, VITAMIN D DEFICIENCY and much, much more...


uniquelyme
Veteran Member


Date Joined Nov 2008
Total Posts : 1037
   Posted 3/6/2010 5:08 PM (GMT -7)   
Yes, I read about that too....I take Methadone along with Oxy IR 30 mg. but I'm thinking about Opana ER.  This new drug might be another option for me.
 
Me.

I have been a spectator for so long..Now it's time to participate.......
 
Post Lamenectomy Syndrome, Spinal Stenosis, DDD....
1999 Hemi Lamenectomy/2005 Spinal Fusion(L4-S1)
Methadone 120 mg. a day/  30 mg. Oxycodone as needed(up to 4 x a day)
High Blood Pressure: Lisinopril HCTZ 10 mg. daily
Type 2 Diabetes: (March 16, 2009)
Metformin HCL ER 1000 mg. at night..Glipizide 10mg. 2X in the morning
Lantus 35 units at bedtime with Solostar Pen                                                                   

 

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