Oxycodone/Naloxone

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CRPSpatient
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Date Joined Mar 2011
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   Posted 11/8/2011 3:43 AM (GMT -6)   
Hi everyone,

Just wondering if anyone has been on an Oxycodone/Naloxone CR medication (here in Australia it's called 'Targin', don't know what it might be called. My GI specialist has suggested I talk to my PM about using it in place of my Oxycontin because of how much worse the Oxy is making my gastroparesis so much worse, but my pain is so severe now that going without it or even dropping the dose back just isn't an option. The naloxone in the Targin is meant to reduce the side effects without compromising pain relief.

would appreciate any feedback :)

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome, osteoporosis, osteopenia.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have SCS, intrathecal pump with baclofen & bupivacaine and doing physio

grandmaroses
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Date Joined Jan 2011
Total Posts : 1355
   Posted 11/8/2011 10:57 AM (GMT -6)   
Hi Laura

I take targin as my long acting pain medication. I have been on various meds but this one works for me I still use oxycodone for break through pain as well. I don't know what else you would like to know but if I can help I will.

Rose
Take care
Rose



Insulin Dependant Diabetic, Fibromyalgia, Gerd, IBS, Sleep Apnea, COPD, Spondylolistesis, Diabetic Neuropathy, Fatty Liver, High Cholesterol

NiNi53
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Date Joined Mar 2011
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   Posted 11/8/2011 7:10 PM (GMT -6)   

Hi Laura, I am sorry I cant give you any information, but I wanted to say Hi, and see how you were doing, I hope you are feeling better and continue to.  I also hope and pray you get the information you need.

 

take care baby girl, I continue to pray for you,

Kathy

 


degenerative disc disease, fibromyalgia, osteoarthritis, neuropathy, lumbar laminectomy july 1998 no help, rechargeable neurostimulator unit low right back w/lead wires to left side and right leg unit not working just sitting there.i am 57 years young in may will turn 58. i have 2 grown daughters, 25 and 29. i have 2 grandchildren, 9 year old grandaughter and 5 yr. old grandson

CRPSpatient
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Date Joined Mar 2011
Total Posts : 1173
   Posted 11/9/2011 5:52 PM (GMT -6)   
Thanks Rose and Kathy :)

I saw my PM yesterday and he had already heard from my GI doctor about starting me on it. Just remains to be seen whether I can afford it. Our Federal Government in its *cough* wisdom decided that it wasn't appropriate to include it on the PBS (subsidised medications) despite all the positives so although they have to confirm, it sounds like it's going to cost me more than $60/box. A box is going to last just under a week, so if they're correct about price it's going to add another $230 a month to my pharmacy bill... my Oxycontin usually costs me $5.60 because I'm on a Disability Pension and is actually free for the rest of the year because I've hit a thing called the 'Safety Net' ... basically, already spent so much money on medications this year that the Government subsidises me for the remainder of the year. There isn't much choice there, is there :(

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome, osteoporosis, osteopenia.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have SCS, intrathecal pump with baclofen & bupivacaine and doing physio

grandmaroses
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Date Joined Jan 2011
Total Posts : 1355
   Posted 11/9/2011 10:32 PM (GMT -6)   
I really hope you can get funding for this, I pay the 250 bucks for a months worth, almost did not fill the Rx because of the cost.
Take care
Rose



Insulin Dependant Diabetic, Fibromyalgia, Gerd, IBS, Sleep Apnea, COPD, Spondylolistesis, Diabetic Neuropathy, Fatty Liver, High Cholesterol

CRPSpatient
Forum Moderator


Date Joined Mar 2011
Total Posts : 1173
   Posted 11/10/2011 3:34 AM (GMT -6)   
Thanks Rose - I'm hoping I can too. Especially as I've found out it's going to be closer to $300 a month for me. I've sent an email to my PM doctor tonight to see if he can find out whether Mundipharma have a compassionate supply program. I believe that Pfizer do, I know that Janssen-Cilag do, so hopefully.

Watch this space anyway. I saw from your message in the 'Where do you live' topic that you're from Canada, but if my doc can come up with anything general that might help you as well, I'll let you know :)

Laura
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome, osteoporosis, osteopenia.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have SCS, intrathecal pump with baclofen & bupivacaine and doing physio

CRPSpatient
Forum Moderator


Date Joined Mar 2011
Total Posts : 1173
   Posted 11/11/2011 2:45 AM (GMT -6)   
Uggh... well I don't know that I'm a fan. I started lunch time yesterday, so I've had four doses in place of the Oxycontin. I know the naloxone is only meant to act locally, but I feel very much like I'm getting opiate withdrawal going on here. I've got crampy legs, crampy stomach/gut and sweats, which is what happens every time I get too sick to keep my Oxy down and start going into withdrawal from that :( Pain relief isn't too great either - and I've gone from 30mg of Oxy 3 x daily to 40/20mg Targin 3 x daily.

Message has been left for my doctor :(
CRPS since 1999, diagnosed in 2005 and since spread to full body, spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bone spurs, bursitis, carpal tunnel syndrome, osteoporosis, osteopenia.

On Oxycontin/Endone, Topamax, Mobic, Magnesium, Florinef, Midodrine, Somac, Cipramil. Have SCS, intrathecal pump with baclofen & bupivacaine and doing physio

rjbeck
Regular Member


Date Joined Feb 2008
Total Posts : 241
   Posted 11/11/2011 5:56 AM (GMT -6)   
If you are taking oxycodone with naloxone these are 2 totally different types of drugs. the oxy is for your pain relief and the naloxone is a against that blocks any other opiate from getting into your system. This drug was made this way so anybody who uses it cannot use any other opiate pain medication because the naloxone will block the effects of the other drug.
 
Naloxone or Narcan is used in ER's for heroin overdoses.when given the patient almost wakes up immediately.
 
Naloxone is a type of medicine called an opioid antagonist. It blocks the actions of opioid medicines such as oxycodone, morphine, morphine, codeine, pethidine, dextropropoxyphene

CRPSpatient
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Date Joined Mar 2011
Total Posts : 1173
   Posted 11/11/2011 6:20 AM (GMT -6)   
Hi No-Relief - I'm well aware of what the difference between the two drugs and what they do :)

The naloxone in Targin isn't intended to work systemically. I'm not 100% sure of the pharmacokinetics, but it's formulated so that it's only supposed to block opiate receptors in the GI tract to reduce opiate-induced constipation in particular. My GI specialist wanted me to try it because I have severe gastroparesis exacerbated by Oxycontin. The only way Targin should (in theory) be able to cause withdrawal would be if it's misused - e.g. crushing the tablets. This is one of the reasons it looks so good as a new pain med because of the reduced potential for abuse c.f. Oxycontin. And it's why I can't understand feeling as though I am getting withdrawal symptoms.

grandmaroses
Veteran Member


Date Joined Jan 2011
Total Posts : 1355
   Posted 11/14/2011 1:07 PM (GMT -6)   
OMG I'm sorry you are having such a bad time on targin. Up to a week ago I was taking targin 20/10 2 x a day for long acting pain relief and up to 10 mg of oxycodone for breakthrough pain. A week ago I have back injections that have relieved my back pain a great deal but I still have pain from other health issues. I thought I should reduce my bt slowly but I just can not handle taking too much I hate that high feeling. Maybe the targin strength is too high I don't know because all I can tell you is for me this drug really works well. Currently I am having withdrawal symptoms from the amount of bt I was taking so am breaking one oxy in half and taking that 2 times a day to help. I am going to have back surgery so I would really like to be on much less pain medication now.
I am actually almost out of my prescription and I am going to ask my dr to reduce the dosage because I am having more rumblings than normal, I am almost afraid to leave the house, lol. I would rather take less targin and more bt. Don't be afraid to tell your Dr what is happening because its like any other medication it will need to be tweeked to your needs.

Htp1001
New Member


Date Joined Jan 2013
Total Posts : 7
   Posted 1/30/2013 7:31 AM (GMT -6)   
I am a newbi her, so 1st. i'd like to say hi to everyone. I can't find much info on here about Targin & everything I have seen is a couple of years old. I was on Oxycontin since 2001, then my PM. & GP. made me go on methadone ( which I hate for so many reasons), so I changed doctors, after weeks of hell. Now I'm seeing my partners' doctor. The 1st.time I saw him, my partner came in with me as he & the doctor get on very well & my partner is also on Oxycontin. The doctor asked if I wanted the old Oxycontin or the new one that just had something extra added to stop constipation. I was suspicious about what this extra drug in them was, but my partner had to pipe up & say that I should get them if they don't cause constipation, so I felt I had to say ok to the new one (Targin), or the doctor would think I was abusing Oxycontin. I'm so paradoid about asking for them now with all the addicts using them now.

As soon as I got them & saw they had Naloxone in them, I was too scared to take them. So my partner gave me his old Oxycontin to use for a few days & he used the Targin. The !st 2 days he took them, he said he was constipated, & he usually went to the toilet 2-3 a morning. Also, he said they didn't do much for his pain either. So the next day, about 5 hours after having 80 mlgs Oxycontin, I finally tried a Targin. I didn't break it or chew it, just took it how your supposed to, & an hour later I was going into withdrawals. A few days later all the Oxycontins were gone & my pain was so bad, I took 4 Targin throughout the day & all day I was sick with bad withdrawals & the pain was getting worse. So we went back to the doctor & told him what the Targin did to us (though my partner didn't get withdrawals) & I asked if I could get some Oxycontin. He changed me over to them. The next time I saw him, I went in without my partner, he was really nasty to me.(He told me when I 1st saw him that he could only give me 2-40 mlgs a day & had to very slowly put me up to my usual dose of 5-40mlgs a day or the Health Dept. would cut me off ).

I asked him how long before my dose could go up a little & he said "oh, your dose isn't going up, I'm going to detox you". I asked what I was supposed to take for the pain & he said "nothing. If you go to Pain Management they will tell you to take a panadol & go home". He gave me a script for Oxycontin, & a hateful look. I left in total shock, slamming the door behind me. When I saw him again yesterday, my partner was with me again & he told the doctor that 2-40mlgso oowasn't enough for me & I needed atleast 3 a day as my pain gets so bad & sometimes I can't even walk. The doctor ignored me the whole time, but gave me a script for 3 a day this time.

I feel like every doctor thinks I'm abusing Oxycontin as I have a very high tolerence (I have to take a Temazepam every time I have an Oxycontin or they do nothing for the pain) & I'm a skinny person. As for Targin, I think the Naloxone in them blocks the receptors in some peoples brain & not others. I was wondering if it could possibly have anything to do with your weight, or maybe your tolerence level. How many people get this problem, apart from CRPS patient & me. Could some more of you on this stuff please give me your opinion of it please? By the way, my pain comes from having blocked arteries in both legs. I've had by-pass surgery, using synthetic grafts, twice & another operation where they tried to insert something into a section of my artery to widen it but it didn't work as my veins & arteries are so narrow. My surgeon said nothing more could be done for me. Sorry, this is so long with no paragraphs in it, but I haven't worked out how to put paraghps in yet.

I've edited your post to include paragraphs. Just press ENTER/RETURN after each paragraph to add spaces. Please do make an effort to do this as many of have eye tracking issues. Thanks, Laura

Post Edited By Moderator (CRPSpatient) : 1/30/2013 9:14:33 PM (GMT-7)


straydog
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Date Joined Feb 2003
Total Posts : 11409
   Posted 1/30/2013 11:04 AM (GMT -6)   
Hello & welcome to the chronic pain forum. Wow, I am surprised that the dr didn't kick you out of the office when you told him you & your partner were taking each others medications. That is considered abusing the medication. That is just something you never do is give your meds to someone else or take someone else's meds. I would imagine that is why he said he was going to detox you. I am really surprised he even gave you more Oxycontin. I would not count on this guy being your dr much longer and I do not understand why he acts differently in front of your partner.

It really sounds like you have built up a tolerance to the Oxycontin and you need to be changed to something else. This is normal and happens all the time when we are on a medication long term.This does not just apply to pain meds but all kinds of meds. I am on blood pressure meds & I build up a tolerance to it & the need to be changed to something else.

It sounds like your situation may get a whole lot worse before it gets better because of the taking of each other's meds. If you are in the states there are new guidelines & rules in place for pain mgt. plus the DEA is now running the show. The drs are really caught right in the middle and they do not want the DEA breathing down their necks either.

Also we ask all new members to start their own intro post.You can copy & paste what you have written above for your intro post.
Take care....Susie
Moderator, Chronic Pain Forum & Psoriasis Forum

Post Edited (straydog) : 1/30/2013 10:00:21 AM (GMT-7)


Poweredbylove
Regular Member


Date Joined Aug 2012
Total Posts : 160
   Posted 1/30/2013 5:11 PM (GMT -6)   
If the oxy is damaging your GI tract, perhaps you would be better off not taking any oral medications at all. Has your doctor ever talked to you about a patch instead of pills? Sounds like you are on a high dose of oxy atm so I would imagine the only patch you would be using would be a Fentanyl patch. I was having problems with my liver/kidneys because of my long-acting morphine about 7 months ago so my doctor switched me over to the patch and it works much better and I dont have to ever remember to take pills or worry that they will damage any organs.

Just a thought.
Age: 28
DX: Lumbar spondylosis, Sacroiliitis, Lumbar radiculopathy, Lumbar disc disease, disc failure L4-L5, disc rupture L1, T11 right protrusion

CRPSpatient
Forum Moderator


Date Joined Mar 2011
Total Posts : 1173
   Posted 1/31/2013 12:27 AM (GMT -6)   
Hi, and welcome to the chronic pain forum. You might like to make an introductory post of your own on the main CP forum page.

I have to agree with Susie in many ways. I'm not sure what country you're from, but oxycodone is a controlled drug. Supply to another person - even if it's to a friend also taking the same med, same dose - is technically illegal. Also - are you saying that usually you take FIVE 40mg OxyContin tablets per day? Or are you talking about an instant release oxycodone med? OxyContin is an extended release med and usually only taken twice a day. Occasionally some doctors script it three times a day - I know this is what my doctor has done for me, because I find it doesn't quite carry me through the 12 hours between doses.
Moderator - Chronic Pain Forum

Full body CRPS with spasms, dystonia & contractures, gastroparesis, orthostatic hypotension,bradycardia/tachycardia, bursitis, CTS, osteoporosis, multiple compression fx, disc bulges.

Oxycodone ER/IR, Topamax, Mobic, Somac, Cymbalta, Lorazepam, Midodrine, Vit D & C, SCS, baclofen/bupivacaine pump

nvrthesame98
Forum Moderator


Date Joined Jun 2008
Total Posts : 4845
   Posted 1/31/2013 3:03 AM (GMT -6)   
Hi Crps and sorry to see your having such a time. I have to say that anytime you enter Nathan into the mix the game has to change. No matter whether it's designed to work locally versus systemically it's still going to cause some degree of w/d in opiate tolerant ppl.

They had the very same problems with the talwin years ago and eventually no one took it and drs stopped prescribing it. Not sure if it's even still on the market and it was a very good pain med but had Avery high abuse rate as this was back in the rise of heroin so it was being used as an IV med and alot of ods attributed to it.

There was talk that nucynta would become the only Oxy available at some point and that's scary but not far fetched. With all the war on drugs going on. What I'm trying to point out is it happened with the talwin and can certainly happen again with oxy.

LexiRae
Veteran Member


Date Joined May 2012
Total Posts : 756
   Posted 2/1/2013 6:12 PM (GMT -6)   
They did change the formula of the "pill" part of the oxycontin, so that it can't be crushed or dissolved nearly as easily (I'm sure someone somewhere has found a way to do it).

I'm hoping that this change will keep it on the market and help to discourage abuse because so far, it's been the best CR/ER pain med, for me. I've been on others and got so sick that it wasn't good for me.
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