Lyrica vs Neurontin

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holydiver
Regular Member


Date Joined Jul 2012
Total Posts : 82
   Posted 5/7/2013 3:03 PM (GMT -6)   
So I have just switched from 2700mg Neurontin (gabapentin) per day, to 300mg Lyrica (Pregabalin) per day.

The difference is incredible! No more super brain fog, I actually feel like a real person instead of fighting through muddy treacle all the time if that makes sense. It is just so nice to be able to make a coherent thought again.

Also it is better with pain relief, not having to take much tramadol for breakthrough pain at all.

So I wonder why I wasn't put on this stuff to begin with, blows Neurontin out of the water in every way.

This is just me though. I am interested to know others' experiences, who have switched from one to the other. I just went straight from Neurontin to Lyrica without any tapering and it has worked well, I feel a bit strange but I'm sure that will pass.

Jim1969
Veteran Member


Date Joined Jul 2009
Total Posts : 2042
   Posted 5/8/2013 12:07 AM (GMT -6)   
Just a theory, but it may be a lot like walking into a restaurant and asking for a Coke (or Pepsi) just because that brand is what you drink the most of and it has become a force of habit.

Neurontin has been around a long time and Lyrica is a relatively new kid on the block.

Then again it could be some kind of insurance issue. Some insurances as well as some medicaid programs require that a certain medication be tried first before moving on to more expensive and/or newer medication are approved. Who knows.

Same basic thing happened to me when I was dx'd with dpn (diabetic nerve damage). Doc stuck me on neurontin for a while and then switched me to Cymbalta. The Neurontin did nothing for me but give me a badly upset stomach and the Cym was like a miracle drug for me. When the doc wrote the script for the Cymb he said this should work really well. Many people have problems with Neuro working until they get to really high doses and the Cymb seems to do the trick with only 1 pill a day so I asked him why we didn't try it first and he kind of shrugged and said old habits die hard.
2 confirmed herniated lumbar discs. Spinal Arthritis. Spinal Stenosis, diabetic peripheral nueropathy.

nvrthesame98
Forum Moderator


Date Joined Jun 2008
Total Posts : 4049
   Posted 5/8/2013 12:38 PM (GMT -6)   
I too was started on neurontin and had the same results. I felt like I was looking at everything through a dirty window.

Switched to lyrica and have done really we'll. I'm no longer on any b/t meds at this time. Was basically on them trying to get relief for sciatic pain and we all know that wasn't working. The lyrica knocks about all but an occasional bout.

Been stable on 300mgs for about a year
" The best thing to hold onto in life is
each other"

Vickie
Moderator chronic pain

Disabled since 1998 on SSD
DX: lft knee TKR. 6 rt knee surgeries for meniscus repair. Pars defect L-5 ,ddd at L3-4 S1. disc collapse at L-3 with nerve impingement. legally deaf,rt shoulder repair 06. post encephalitis/migraines
MEDS: methadone,lyrica,zantac,maxide,K+,lasix,prempro,flexeril,indocin

Snowbunny21
Veteran Member


Date Joined Jan 2010
Total Posts : 3557
   Posted 5/8/2013 12:57 PM (GMT -6)   
That's great that you are doing well on the Lyrica! As mentioned, it really is trial and error for all of us to find the best combination of meds and treatments to help our pain levels.

I used Cymbalta for 3 years and that worked extremely well for me as the Neurontin made me too foggy/dizzy.

I think that is why so many of us encourage those who have any type of nerve pain to try and add one these meds to see which one suits them as most opiates really don't work well for that specific type of pain.

Hope it keeps going well for you!
SB (Snowbunny) and the pup that snores (my yellow lab:))

3, two-level, cervical fusions over the past 11 years. The last one was anterior and posterior with lots of fun titanium!
Still have active herniations along with knee problems and another Morton's neuroma in left foot.
I try to find joy in each day even with chronic pain:)

Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 6796
   Posted 5/8/2013 6:42 PM (GMT -6)   
I began taking Neurontin in 2004 for PN due to Crohn's disease. A couple years later, the neurologist suggested switching to Lyrica. By the third day, my PN was totally out of control, the pain, burning and tingling was driving me crazy. I decided to saw my feet off. Thankfully, my daughter was home and stopped me. She also had to practically sit on me until the med wore off enough for me to become coherent. Then called neuro who said some people can have "negative psychriatric issues" when on Lyrica.

I am glad that you found better relief on Lyrica. Obviously, it was not the right med for me.
Moderator Crohn's disease, Osteoarthritis and Irritable Bowel Forums

CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, pulmonary hypertension, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

holydiver
Regular Member


Date Joined Jul 2012
Total Posts : 82
   Posted 5/9/2013 2:19 PM (GMT -6)   
Ideas: That sounds awful, sorry to hear that. Everyone is different, what works for some with minimal side effects is often not effective for others. I for example respond terribly to Amitriptyline, a relatively low dose sends me loopy, really horrible psychological effects including genuinely suicidal thoughts. Was quite scary

Anticonvulsant drugs seem to be ok for me so far, starting another one soon along with the Lyrica so will see how that goes.

Jim: I have no insurance, it is all covered by government healthcare in England where I live. I have read that Lyrica is a lot more expensive than Neurontin though so perhaps that is why they don't have it as the first-line med. I am sure there are many people out there who get on better with Neurontin anyway regardless.

Lindaloo
Veteran Member


Date Joined Sep 2006
Total Posts : 1710
   Posted 5/10/2013 11:31 PM (GMT -6)   
Hi
 
I have been on 200 mg of  Lyrica, twice a day,  for years now and  I have always thought it had contributed to my fogginess and general difficulty in thinking.  Now, after reading several of your posts, I am rethinking that and feeling that maybe it just may all be contributed by my pain medicine, Oxycodone 15 mg every 4 hours about 4 times a day.
 
I take other medications for depression, and know that they too, may be part of the problem, but I was on them for years and years before the Lyrica and Oxy, so I tend to think it is coming from them a lot less than the Lyrica and Oxy.
 
It's interesting to hear of how everyone relates to different meds and of course, no two people are alike.
 
Have a blessed day.
 
Lindaloo

anice1
Regular Member


Date Joined May 2013
Total Posts : 63
   Posted 5/11/2013 2:00 AM (GMT -6)   
 I couldn't take Neurontin personally. I had horrible very violent nightmares while taking it. I also tried Elavil. It made it too hard to get up in the mornings, and I felt funny/disoriented all day. And with Cymbalta, it ended up also having negative affects for me. It made me severally depressed.  The PA at my pain management has mentioned Lyrica for me. But I guess I didn't give it long enough. I couldn't tell  a dfference in how it was beneficial to me. I just didn't continue it at the higher dosage. And I heard it was expensive. I have good insurance, but haven't met my deduct. yet with pharmacy.
   Reading the comments that were good about Lyrica, it makes me want to try it agan....but I am afraid I possibly won't be able to afford it.

holydiver
Regular Member


Date Joined Jul 2012
Total Posts : 82
   Posted 5/11/2013 1:38 PM (GMT -6)   
Lindaloo: It is hard to say, every person is different. The Lyrica still causes the same forgetfulness thinking difficulties as Gabapentin for me, but at to a much lower degree. I am sure if I upped the dose further It may not be tolerable.

anice1: Sorry to hear you have a bad time with these drugs. You could try Lyrica again at a very low dose to start with, but I would imagine chances are if Neurontin was bad then Lyrica would be too since they are very similar drugs. I react horribly myself to SSRI drugs, even very low doses, would never touch one again. Amazing how all our brains and body chemistry are so varying...

Anyone know what the max general dose of Lyrica is? I am at 300 and wondering how much higher I can go. It is not working so well for me since I made the original post in this thread, perhaps it was just the effect of a new drug and I have become tolerant to Lyrica very quickly due to previous Neurontin tolerance

Snowbunny21
Veteran Member


Date Joined Jan 2010
Total Posts : 3557
   Posted 5/11/2013 1:56 PM (GMT -6)   
Rxlist mentions that there were studies done all the way up to 600mg a day but didn't see any rise in actual effectiveness over the 300mg a day as well as there were more adverse reactions.

So the 300mg is the recommended highest dosage but you can speak with your Dr. to find out more information.

It would be quite strange to be actually "tolerant" of a med in 4 days...It could be just that you are going to notice and "feel" a medication and difference when first taking it.

Unfortunately with any type of chronic pain, it's always going to be where each modality we use, from a medication to any type of treatment, is going to just help by taking our pain down a tiny notch. It's about adding everything we do to get to that pain level of 5 or better if lucky.
SB (Snowbunny) and the pup that snores (my yellow lab:))

3, two-level, cervical fusions over the past 11 years. The last one was anterior and posterior with lots of fun titanium!
Still have active herniations along with knee problems and another Morton's neuroma in left foot.
I try to find joy in each day even with chronic pain:)

holydiver
Regular Member


Date Joined Jul 2012
Total Posts : 82
   Posted 5/11/2013 2:38 PM (GMT -6)   
I have seen similar reports of 300 being the max, however have also read of peopel taking quite a bit more per day. I am reluctant to go any higher for fear of side effects being too much to handle, 300mg seems to be ok for me in terms of higher mental functioning etc, sure I would rather not be on it still but is manageable.

I just need the sudden insane stabbing attacks to stop, really ruins the ability to plan and do anything when there is a constant fear of this coming on at any moment.

Am starting Lamotrigine alongside this week, I figure it is better to be on lower doses of two drugs than a massive dose of one.
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