Especially given that your sister has had epidural corticosteroid injections, there raises the possibility of secondary adrenal insufficiency as a source of widespread body muscle and joint pain.
Secondary adrenal insufficiency is not on thr radar of most physicians. People often struggle for years traversing from MD to MD before being accurately diagnosed. An endocrinologist with pituitary speciality is a necessary resource. This can be a complex diagnosis.
The Pituitary Network Association is a credible resource center. www.pituitary.org
So, too, the National Adrenal Disease Association.
Cortisol is produced by the adrenal glands regulated by a negative feedback loop with the pituitary gland. Cortisol is a life essential hormone (chemical messenger). Cortisol is needed by every cell in the body. As such, low cortisol due to adrenal insufficiency has symptoms that span a broad spectrum. Different organs and body systems metabolize cortisol at different rates - and this varies from person to person, depending on their natural high and low energy demands. Ex. A person who is athletically inclined may show more muscle and joint pain; a person who is cerebrally inclined and analytical may show more cognitive symptoms.
A universal symptom common to all suffers of adrenal inadequacy is the symptom of pronounced and diffuse muscle and joint pain. I described my body experience as total body pain. Every fiber of my being ached, a deep ache. Cortisol is the body’s principal anti-inflammatory agent. Low cortisol secretion = High systemic inflammation of soft/connective tissue, muscle, and bone = profound and diffuse body pain. Mm
Symptoms of secondary AI: Diffuse and severe muscle and bone pain; nausea, vomiting and generally queasy gastrointestinal System, low appetite; low blood oressure, vertigo/ dizziness when changing body positions as in sit to stand or lying down to sitting or standing; orthodratif low blood pressure; brain fog, decreased higher level thinking and executive thought processes; sensitivity to lights and sounds and touch; profound fatigue, not relieved by rest; insomnia, interrupted sleep.
Secondary adrenal insufficiency develops slowly over the span of months and years. Symptoms tend to wax and wane as the pituitary gland does it’s best to compensate. It is common for a person with developing secondary adrenal insufficiency to be able to function fairly well on a given day, only to find that he/she is depleted the following day and seemingly unable to do much more than basic/simple tasks. This pattern of functioning one day followed by a day where the person is almost bedridden is a common thread as the disorder progresses. On a day that a person is able to function the body’s cortisol deserves are expended and depleted by that day’s tasks and engagements. The “tank is empty” so to speak the following day. And the person lies apathetically, often to he frustration of friends/family members.
I wanted to compose a thorough profile of adrenal insufficiency because your sister’s profile of seeking multiple physician consultations over years without a fruitful diagnosis is a common thead of those eventually diagnosed with AI. A recent clinical study found that the median timeframe for assigning an accurate diagnosis is 7 years. Seven years of futile physician consultations and futile diagnostic testing. Seven years where a person is summarily dismissed by one MD after another. Seven years of anguish and a deteriorated quality of life. Adrenal insufficiency is simply not on the radar of the average physician. It is imperative that a person suspecting adrenal insufficiency can advocate on his/her own behalf to seek an accurate and timely diagnosis.
Pituitary failure, wide-spread endocrine dysfunction
Mixed connective tissue disorder
Extensive intestinal perforation with sepsis, permanent ileostomy
Avascular necrosis of both hips and jaw
Receiving Palliative Care (care and comfort)
Post Edited ((Seashell)) : 10/5/2017 4:41:18 PM (GMT-6)