Taking it at night is a good suggestion. The other thing is if you are taking it during the day, ie. the morning, make sure you take it with a substanstial meal. I have found that if I take Imuran on an empty stomach or even with something like a piece of toast, that in 2-3 hours I will get very nauseated. If I eat a good breakfast, then I usually have no problems. I also carry around crackers or pretzels to ward off the "queasy" feeling I sometimes get.
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CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?