anyone get really sick from Imuran?

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bluemeanies
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Date Joined Jun 2004
Total Posts : 1372
   Posted 1/14/2008 10:33 AM (GMT -7)   
I was wondering if anyone here has gotten really sick from Imuran. I started 150 mg/day a few weeks ago and took it with dinner. Ten days ago I started throwing up and dry heaving for 4 hour hours at a time at night, usually from 12:30 am to around 4:30 am. My gi at first said it was a virus but I've never had a virus where you puke the same time every day. Well I ended up at the hospital on day 7 with dehydration, I got 3 bags of iv fluids. That night I did not take the Imuran and was ok. The next night I took it and was sick. Didn't take it last night and was ok. So I emailed my doc and told her I'm stopping it.

And I was fired from my job because of the absences. How can you go to work after spending 4 hours throwing up and dry heaving instead of sleeping? This past 10 days have been horrible. I am so weak, but I did drop 8 pounds in 7 days (not the right way to loose but still a loss, hee hee hee). Luckily, my room mate has been great about this (I scared her, she thought I was going to die when I started getting blurry vision and almost passed out). And I have a place to live while looking for my next new job, she won't kick me and my cats out. I am blessed to have such a great friend.

Anyway, I was just wondering if Imuran did this to anyone else. Thanks.
 


Boston
Regular Member


Date Joined Mar 2005
Total Posts : 60
   Posted 1/14/2008 12:46 PM (GMT -7)   
When I first started taking Imuran, I started out at a lower dose. I think I started at 50mg/day and worked my way up with bloodwork done every 2 weeks. Within 2 months I was up to my reg dose I take now which is 150mg/day. I take mine at night and had never had any issues you are having. Ive been on it for over 2 years now. Im not sure if you are suppose to start with that amount. Hope you feel better soon.

immunosci
Regular Member


Date Joined Jun 2006
Total Posts : 326
   Posted 1/14/2008 2:22 PM (GMT -7)   
My response to Imuran was exactly like yours. My gastro took me off it and put me on mercaptopurine. Mercaptopurine is one of the breakdown products of Imuran and can be easier for some to handle. I've been fine with the mercaptopurine for 2 years so far. No nausea or vomiting. You might check with your gastro to see about trying mercaptopurine. Also, there's a blood test that can be run to check your blood levels of Imuran and mercaptopurine. It wouldn't hurt to have that run either. Feel better soon.

Jen
-Formal diagnosis of Crohn's Disease in ileum in July 2005.
-Experienced what were most likely flares for 12-15 yrs.
-6-MP, protonix, cymbalta, wellbutrin, trazadone, miralax, allegra, celebrex


pdmhol
Regular Member


Date Joined Apr 2007
Total Posts : 40
   Posted 1/14/2008 3:01 PM (GMT -7)   
I also had the same response to Imuran and my GI switched me to 6mp also. I,ve been on 6mp for over a year.
Crohns dx in 2002. ilieum and colon resection 2002. Ilieum resection 2007.


kimberlayn
Regular Member


Date Joined Jul 2007
Total Posts : 239
   Posted 1/14/2008 3:08 PM (GMT -7)   
I'm on 150mg Imuran too and I'm not having any problems, it's been 8 months. My doctor had me take it 50mg at a time, three times a day for 2 weeks, then 100mg in the morning and 50mg in the evening for a month, and now I swallow them all down with my Entocort (only 2 now!), 2 vitamins, a probiotic, and blood pressure pill that keeps my BP from dropping. He said that by taking the pills throughout the day it might help keep the nausea at bay, and it worked like a charm. Try explaining that to the nurses in a hospital though. If the script says to take 150 once a day, it's like fighting a tiger to get them to let you take it another way! Doing their jobs, and doing them well, I know!
diagnosed 11/06, solving the mystery of years of on/off abdominal pain. No more "it's just a virus". 33f with 2 boys, a lovable dog, and a wonderful husband. 150 mg Imuran, bowel resection 9/07, healing well and feeling well. Entocort 9mg.


ana_e
Regular Member


Date Joined Feb 2007
Total Posts : 67
   Posted 1/14/2008 4:22 PM (GMT -7)   
Our 3 yr old(last year) daughter got pancreatitis from Imuran and had to be hospitalized for 10 days. We were asked my her GI to get regular blood tests done(1-2 every week) to see if she would get pancreatitis because its a known side-effect of Imuran which can occur in certain people. She had to be taken off Imuran and put on steroids instead.

================================================

bentwistle
Regular Member


Date Joined Jul 2006
Total Posts : 330
   Posted 1/14/2008 4:51 PM (GMT -7)   
The 6-MP wiped out my immune system for a few weeks and injured my liver. I was hospitalized as a result. At first I thought I had a bad flu -throwing up. etc, but shortly thereafter I became extremely feverous and alternated from chills to burning up. I have never felt so sick in all my life since. I cannot tolerate imuran or 6-MP.
I'm sorry to hear about you job loss. Some people can be so insensitive regarding other's health issues. I wish we could let them live one week in our shoes during a flare or a medication reaction!

Good luck and hope you're feeling better soon.

Bev

Sharann
Veteran Member


Date Joined Sep 2005
Total Posts : 778
   Posted 1/14/2008 5:40 PM (GMT -7)   
Yes I was VERY sick from Imuran within 15 minutes of even 50mg doses. I vomitied until I dry heaved. Also went to ER for IV fluid resussitation due to dehydration. It was awful. My brilliant GI at the time also told me it was a "virus" and to keep taking it. Well, I took it one last time and that was it for me.
I am currently on 50 mg 6mp and doing very well, just started this week, but am on steroids for 10 days as well so I will know after the pred is finished.
Try 6mp if you can, it may be easier on you.
Feel better !!
I am a Certified Doxie Lover(Weinerdogs)


Reef08
Regular Member


Date Joined Dec 2005
Total Posts : 267
   Posted 1/14/2008 7:00 PM (GMT -7)   
I'm starting Imuran on Wednesday. This thread has really made me feel more confident about it. sad

Reef08
Regular Member


Date Joined Dec 2005
Total Posts : 267
   Posted 1/14/2008 7:01 PM (GMT -7)   
So if 6-MP is a metabolite of Imuran and causes less side-effects, why do they prescribe Imuran anyways?

Sharann
Veteran Member


Date Joined Sep 2005
Total Posts : 778
   Posted 1/14/2008 11:42 PM (GMT -7)   
Reef08 said...
I'm starting Imuran on Wednesday. This thread has really made me feel more confident about it. sad
Sweetie, no worries. Imuran is a miracle for some people! YOu may do great on it. Just try it, you will soon enough find out.:)))
 
I am a Certified Doxie Lover(Weinerdogs)


teddybearweiser
Veteran Member


Date Joined Oct 2004
Total Posts : 3042
   Posted 1/15/2008 3:41 AM (GMT -7)   
Hi, I sorry about your job. they can be very cruel to ppl whom have an illness. On the other side I am on Imuran 150 mg I have no problems and no-side effects. I think your doctor started you on to high of a dose. I started on a lower dose of imuran they my GI doctor moved me to 150mg were i am now.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007
 


karendee
Veteran Member


Date Joined Mar 2007
Total Posts : 1642
   Posted 1/15/2008 8:23 AM (GMT -7)   

I also am on 150mg and have no problems. I did start on 50mg and my Doctor gradually increased it by 50 mg each time so that may have helped. It is possible you could not tolerate it. I hope you get a solution like the others suggested 6-mp or maybe you can try 50mg of Imuran at first. I gradually got used to mine I was nauseous at the beginning.

good luck!

Karen


 ...

Karen (Karendee)

Diagnosed w/ Crohn’s Disease  March 2007 On 150mg Azathioprine (generic Imuran), Pentasa, & Entocort (take zofran for nausea now)

Diagnosed w/  Fibromyalgia May 2007 also on Soma

Also have Arthritis, and feel like I am falling apart sometimes...


njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 1/15/2008 8:30 AM (GMT -7)   
Any med can cause problems. Cipro is fine for most people, but it caused my daughter to have fever that we had to fight for hours to keep below 104 degrees Fahrenheit.
 
This is why, with starting any new Crohn's med, no matter how "safe" it is supposed to be, it is important to keep a close watch on side effects and run blood tests to check for hidden side effects.

Erik45
Regular Member


Date Joined Oct 2007
Total Posts : 149
   Posted 1/15/2008 9:07 AM (GMT -7)   
Hi no problems here been on it for 3 years, so no worries.. :)
Crohns for 11 years
1 surgery so far
2 times in hospital for blockages
MEDS:
Remicade
Imuran
B12 Injections


andorable
Veteran Member


Date Joined Jun 2005
Total Posts : 981
   Posted 1/17/2008 6:11 AM (GMT -7)   
hi there i have had probs with imuran as well, after taking them for about a week i ended up in the er fighting for my life after getting severe hepatitis from imuran. I now have infliximab regularly and so far doing ok on that altough it seems like my options are running low. Anyway thats a whole new story will tell u all about it when i am more up to it right now think i need to sleep/   Hope u are all well take good care
andorable

lady1012
Regular Member


Date Joined Nov 2006
Total Posts : 304
   Posted 1/17/2008 6:50 AM (GMT -7)   
I take my 2 imuran every am with my entocort right after breakfast and i haven't had any problems and I have been taking the imuram for a month now.
I'm cute. Let's put me in charge.(happy bunny)
 
 
 anemia, b12 deficiancy, and malobsorption, moderate joint pain,severe weight loss, gastritis
 omega 3, digestive enzyme, calcium, vit d, flax oil, aloe vera juice, 9mg of entecort
 diagnosed with a CT scan september of 2007.


nruth
Regular Member


Date Joined Mar 2006
Total Posts : 195
   Posted 1/17/2008 10:03 PM (GMT -7)   
It made me violently ill, too. It was fine as long as I was on prednisone, but once I stopped that, taking Imuran was like taking poison.

fan4iu
New Member


Date Joined Dec 2007
Total Posts : 8
   Posted 1/18/2008 6:37 PM (GMT -7)   
Me too!  I went off prednisone two weeks ago, and have been having horrible problems with the Imuran, but my doctor doesn't believe me!  He says its my disease causing the problems, not the medicine.  He even wants me to increase my dose on Monday!  I'm scared to do it!  I have two reactions, either I get bad stomach cramps and throw up, or it gets past my stomach and causes bad gas, bloating and explosive D.  I'm not sure how much more I can take! 

39 years old - diagnosed with Crohn's in 2007
Currently taking Imuran 75 mg


straydog
Forum Moderator


Date Joined Feb 2003
Total Posts : 13473
   Posted 1/18/2008 9:12 PM (GMT -7)   
Been on it 3 yrs w/no problems. It is known for causing nausea. My gi has all his Imuran patients take it at bedtime to avoid this problem. Susie


nruth
Regular Member


Date Joined Mar 2006
Total Posts : 195
   Posted 1/19/2008 9:50 AM (GMT -7)   
Yes, I had to argue with my doctor, too. They really don't always know best. Listen to what your body is telling you. Just stop taking the stuff.
fan4iu said...
Me too!  I went off prednisone two weeks ago, and have been having horrible problems with the Imuran, but my doctor doesn't believe me!  He says its my disease causing the problems, not the medicine.  He even wants me to increase my dose on Monday!  I'm scared to do it!  I have two reactions, either I get bad stomach cramps and throw up, or it gets past my stomach and causes bad gas, bloating and explosive D.  I'm not sure how much more I can take! 



thenay
Regular Member


Date Joined May 2006
Total Posts : 167
   Posted 1/19/2008 3:21 PM (GMT -7)   
I never got sick on Imuran, but I started at 75mg, 6 weeks later went to 150mg and I got really tired, and went back to 75mg.
The dosage might be too high for you, or it's not for you at all, either don't give up and talk to your doctor :)
Male DX with CD May 2006 @ age 22, Colonoscopy and SBT
Taking Prednisone 2.5mg, Imuran 75mg, Atenolol 25mg for fast heartbeat (thanks Pred!)
Have used Pentasa, Entocort in the past


minnow
New Member


Date Joined Jan 2008
Total Posts : 6
   Posted 1/19/2008 5:08 PM (GMT -7)   
So sorry to hear of your experience with Imuran. My daughter is taking 75 mg/daily and hasn't had any side effects that I am aware of but it is possible that you are having a problem with additives in the medication. My daughter's GI doctor would only prescribe the Brand Name (no generic was allowed he said!) You may want to discuss that issue with your doctor. Good luck!!

magnetic
Regular Member


Date Joined Apr 2006
Total Posts : 84
   Posted 1/24/2008 1:23 PM (GMT -7)   
I had bad experiences with Imuran
I kept getting nausea and felt like getting sick lots of the time.
I was perscribed an anti-nausea tablet to help and that with the imuran kept me absolutely exhausted, I ended up stopping both and phoning the Specialist to let him know, I was changed to Methotrexate and had no problems with it
Diagnosed June 2005 with Crohns (left colon, large bowel)
Diagnosed Osteopenia Feb 2006
Jan07 Arthritis noticed in hands, not too bad yet
Crohns Arthritis Diagnosed January 2008
Remacide started March 2007
Asthma since childhood
 
changed my style to silver
changed my clothes to black


minnow
New Member


Date Joined Jan 2008
Total Posts : 6
   Posted 1/29/2008 3:00 PM (GMT -7)   
Magnetic...my daughter has also experienced terrible fatigue and will sleep 12 hours a day if I allow her to.  She just seems to be doing well and I don't want to cause her any more problems (i.e. side effects)
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