Immune System Question

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indigosunrise
Regular Member


Date Joined Nov 2007
Total Posts : 497
   Posted 1/24/2008 10:17 AM (GMT -7)   
First I would like to thank everyone for being so kind and quick to respond to my previous posts--you all are great!
 
My question this time is have they proven Crohn's is caused by the immune system over reacting and attacking our digestive tract or is that just a theory?  And if the immune system does do that, does that mean that those who have Crohn's or UC or any autoimmune disorder can end up getting ill more often than others because the immune system is always in "high gear"?
 
 

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 1/24/2008 10:59 AM (GMT -7)   

Here's an informative link that will hopefully answer your question...also note that IBD is genetics, one must be predisposed to getting IBD, it's a matter of it being triggered.

 

http://www.irishscientist.ie/p18.htm

and here's another....

 

 http://www.gi.org/patients/gihealth/ibd.asp

 

:)



My bum is broken....there's a big crack down the middle of it!  LOL  :)

Post Edited (pb4) : 1/24/2008 11:05:55 AM (GMT-7)


rootsmith
Veteran Member


Date Joined Jan 2004
Total Posts : 598
   Posted 1/24/2008 11:12 AM (GMT -7)   
Assuming I do have CD, I never seem to get sick with anything specific, even with a WBC count of 2.2 I feel generally lousy most of the time, but nothing I can identify. The gut pain seems to be taken care of by pentasa. So, even though my immune system must be out of whack, I don't seem to catch what's going round, either respiratory or intestinal flu.
10 years, many tests, 3 gi doctors, Pentasa 1000mg 3x day
diovan, simvastatin and now trying good ol' zoloft


stkitt
Forum Moderator


Date Joined Apr 2007
Total Posts : 32602
   Posted 1/24/2008 11:57 AM (GMT -7)   

Good Question.  Thanks for the websites too.  My hubby is not on any of the meds and he rarely gets ill, not prone to colds or sorethroats.  In fact it is myself that got the pneumonia last year and he took care of me.

Again I guess it depends on the individual and how severe your Crohn's Disease is.  I too love the way the members respond so quickly.


 
Kitt, Co-Moderator: Anxiety ~ Panic  ~ Crohn's
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pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 1/24/2008 1:24 PM (GMT -7)   
Yes, it's very individualistic, even at my worst flares with severe D, bleeding, weight loss, ect I very rarely get the stomach flu or colds, ect.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


MikeB
Veteran Member


Date Joined Mar 2006
Total Posts : 1169
   Posted 1/24/2008 1:43 PM (GMT -7)   

The genetic link is key to the prevailing theory about Crohns -- that it is an overactive immune response to one or more triggers or irritants, caused by a faulty gene. In some patients the runaway immune response (which causes the chronic inflammation that is the hallmark of the disease) is limited to the wall of the GI tract. In some others it can be a more general response, hence the Crohns-related arthritis, skin conditions, etc. that those patients get. But it does not make sense that an overactive immune system, even if it is general rather than specific to the gut, would make one more susceptible to other illnesses. Iin fact, it ought to be the reverse, and it seems to be that way with me. Rarely get colds or flu type illnesses. Aside from a heightened immune response in my small gut and terminal ileum, with the trouble that causes, I am in overall good health and have been for the 40-some years I have had this disease.

Of course this is the prevailing theory . . . which seems logical in light of the causes and genetic roots of a lot of other autoimmune diseases. It remains to be absolutelyproven for Crohns, but I buy it and most doctors and patients do too.  


indigosunrise
Regular Member


Date Joined Nov 2007
Total Posts : 497
   Posted 1/24/2008 2:08 PM (GMT -7)   
Thanks everyone!  Thanks for the websites pb4!  They were very informative!
 
It does make sense that if your immune system is "concentrating" on your gutt that it might not pick up on all the other viruses and stuff that is out there. 
 
The faulty gene makes sense, too.  I wonder if many of the autoimmune disorders are believed to have a faulty gene.
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