Allergic Reaction/rash & Humira

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Trsora1
Regular Member


Date Joined Nov 2007
Total Posts : 111
   Posted 1/30/2008 5:43 AM (GMT -7)   
anyone have an allergic reaction to humira?  if so how long did it take before you took first dosage to when you broke out in a rash or itching??  Started end of october and beg of january red rash all the time all over my face and parts of my body.  Not sure if the rash is even from that.   

teddybearweiser
Veteran Member


Date Joined Oct 2004
Total Posts : 3042
   Posted 1/30/2008 6:00 AM (GMT -7)   
Hello, Have you called your doctor yet? I would call you doctor to find out if it is a allergic reaction to the Humira or not.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital
in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.
 My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
My Internest doctor has me on Lisnopril-HTCZ and Folic Acid. Diagnosed
with Osteoarthritis July 2007
 


Trsora1
Regular Member


Date Joined Nov 2007
Total Posts : 111
   Posted 1/30/2008 7:02 AM (GMT -7)   
yeah i went to allergy dr. yesterday they have no idea we are going to start testing for food allergies next sat and then as soon as i get off steriod then we will start testing for other types of allergies.  Steriod will make results not accurate.

Jillybean1887
Regular Member


Date Joined Jan 2007
Total Posts : 56
   Posted 1/30/2008 8:56 AM (GMT -7)   
I have a latex allergy and after speaking with the company that makes Humira I was basically told to stop taking the medication. Great. I now premedicate with Hydroxzyine and have less of a skin reaction. Benadryl did nothing for me. The only place I have a reaction is the injectin site which I now is normal but mine was to the point that the GI suggested to premedicate. So far so good. Good luck. I hope that you find a reason.

Jill

CrohnsDaddy
Regular Member


Date Joined Oct 2007
Total Posts : 235
   Posted 1/30/2008 9:48 AM (GMT -7)   
In the Full Prescribing Information for Humira, it says that if you get a butterfly shaped rash on your nose and face to get to the doctor immediately.
Just trying to be a "Regular Member".
 
Entocort 9 mg/day, Pentasa 4 gm/day, started Humira 1/22/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.


Lauren21
Regular Member


Date Joined Jan 2007
Total Posts : 200
   Posted 1/30/2008 10:37 AM (GMT -7)   
yep i had an allergic reaction to humira. that stuff is the devil.
 
i started taking humira in mid september and on dec 1 i had a horrible reaction. rash and other things, the scariest thing was my throat closed up so i ended up in the ER.
 
if you would like to know more please feel free to email me.

22 year old female
Crohn's Disease (diagnosed 2006)
Humira- stopped due to allergic reaction on Dec 1, 2007
Pentasa
Levbid
 
 
Polycystic Ovarian Syndrome
Anxiety Disorder
Psoriatic Arthritis
Costochondritis
Using Darvocet & Lortab for Pain
Tigan for nausea
 
 
 


mcleaver1969
Regular Member


Date Joined Jun 2006
Total Posts : 267
   Posted 1/30/2008 12:47 PM (GMT -7)   
Yes, the only side effect I have gotten from Humira is the all-over itching, for me it starts a few days after my injection, and lasts about 24 hours, and then I take some Benadryl and it goes away, recurring again after my next dose. To me it's a small price to pay for the results I have gotten with Humira...which have been amazing!
Marci, 38 years young, Rockledge, FL
Dx with Crohn's disease March 2006
Currently on bi-weekly Humira, daily 6mg Entocort, daily 2-3x 5mg hydrocodone (for pain), and daily 75mg Effexor,
plus 3x per day heavy iron supplements for anemia,
calcium supplement, daily multi-vitamin,
Lasix as needed for ankle/feet swelling
Self-proclaimed "recluse"  do to CD  ;)


Jack11
Regular Member


Date Joined Oct 2006
Total Posts : 48
   Posted 2/1/2008 5:47 PM (GMT -7)   
anti tnf drugs are known to cause psoriasis in in some individuals (even though it is supposed to help it in others). I was on Remicade and got a itching rash that 2 dermatoligist said was psoriasis or possibly escema. Stopped taking Remicade, even though it was working well for the crohns, as it was so bad, was embarassed to wear shorts. Never had it before the Remicade. Have since started Humira and am hoping it does not flare up again. Have gotten a few small red spots on my legs, to early to tell yet what will happen. So far have taken 4 doses. Dermatoligist said it may or may not come back with the Humira.
 

broomhilda
Veteran Member


Date Joined May 2007
Total Posts : 1488
   Posted 2/3/2008 6:42 PM (GMT -7)   
I'm dealing with a fungal skin infection from humira. Recently got a fax from the manufacturer at the pharmacy I work at that stated anti tnf drugs can cause these as well. Just thought I'd put this out there. Rash started with remecaid and got worse on humira for me, however, it was treated as psorasis for 2 years! Switched dermatologists this month!
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.


wanthealth
Regular Member


Date Joined Feb 2008
Total Posts : 78
   Posted 2/3/2008 9:21 PM (GMT -7)   

I'm new at this--hope I'm doing it right.

I'm on Humira and also have a rash that the dermatologist diagnosed as psoriasis.  Now I'm wondering if that's what I have.  Will certainly bring it up at my next visit.

Have been reading posts for a while and am very grateful for everything I have learned from the forum.

Thank you.

 

 

 

 

 

 

 

 


broomhilda
Veteran Member


Date Joined May 2007
Total Posts : 1488
   Posted 2/5/2008 9:49 PM (GMT -7)   
moodindigo- My "rash" starts out with little red bumbs (not pus filled), then becomes flaky and the bump kinda spreads out. As it starts clearing up, I'm left with a flat surface ring that looks like a ringworm but is not. Then the bump goes away. The steroid creams the derm gave me for the last 2 years somehow helped "somewhat" to keep the rash at bay...probably by reducing the inflammation some, however, with the steroid creams the rash never went completely away. The way I was able to tell for sure it was fungal was by rubbing a small area of the rash with mineral oil to protect the skin and then applying a crushed clove of garlic (has antifungal/antibacterial properties in it) to the affected area once a day. The area immediately responded by improving! I once cleared up oral thrush with the garlic applied to the tongue (without the mineral oil), once a day for three days! You have to be careful with crushed fresh garlic though because it burns and of course it stinks! I did try opening up the non-scented garlic oil caplets and applied it to the skin...but doesn't work as well as the fresh, real clove. Since my husband wouldn't sleep with me via the garlic stench I now apply mineral oil & tea tree oil after my shower each day. Tea tree oil has antifungal/antibactierial properties too. It also will burn the skin but does smell "somewhat" better than the garlic! I put about 4 drops of tea tree oil per every 2 ounces of mineral oil. Also, I'd recommend using a natural bristle bath brush instead of a wash cloth so you can exfoliate the skin and promote healthy skin cells to the surface. When the bath brush has the scales out of the way the oils can penetrate the good skin underneath the dead skin scales. Good luck to you and I hope this helps....oh, and don't expect to catch any good lookin' italians with the garlic routine...even the dog thought I smelled funky!
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.


wanthealth
Regular Member


Date Joined Feb 2008
Total Posts : 78
   Posted 2/6/2008 9:08 AM (GMT -7)   
Thanks for your response, Broomhilda. Your comments are very helpful. My "rash" is similar to yours. Steroid creams help somewhat also, spots subside but don't disappear. I see the doc in three weeks--until then I'm going to try some of your remedies and sleep on the sofa. Thanks for the warning!
Moodindigo

Jack11
Regular Member


Date Joined Oct 2006
Total Posts : 48
   Posted 2/6/2008 3:40 PM (GMT -7)   
Hmm, the fungal infection kinda sounds like what I have too. The steroid creams never did make it much better, mostly just did not itch. I stoped taking Remicade because 2 dermatoligists said the rash was psoriasis. I stopped Remicade in August and my skin never did compleatly clear up, but the bright red splotches did fade to a tannish color and I had stopped the steroid creams. Now that I have started Humira, sometimes they do look a redder and sometimes not,but does seem to be getting some what worse. If I stopped the Remicade for a fungal infection I won't be happy. Not sure how to crush garlic cloves (do you just rub garlic from the supermarket on?), but will look into it.   

ALI9
Regular Member


Date Joined Jan 2008
Total Posts : 95
   Posted 2/6/2008 4:26 PM (GMT -7)   
I also have an allergy to latex and have reacted to the humria pen, I had just started my 2nd dose after the starter dose each time i had a bad headache and would feel stuffy, not to mention the night sweats and being tired. One hour after my injection i became very short of breath , I took benadryl right away I went to bed thinking it would just go away. The next morning i woke to it sttill being there i took more benadryl and went to work @ 8 am I called the Dr he told me to go to ER or my internist I went to my internest and was told by both to stop the Humria and put me on prednisone and benadryl sad It was my last resort I have been on everything up to this. I E-mailed the company and suggested that they make their product latex free, they have been calling and e-mailing me several times since so...voice your concerns with the abbott company.

Post Edited (ALI9) : 2/8/2008 2:37:10 PM (GMT-7)


broomhilda
Veteran Member


Date Joined May 2007
Total Posts : 1488
   Posted 2/6/2008 10:23 PM (GMT -7)   
Sorry to hear that ALI9, it does sound like you had a severe reaction. Glad you remembered the benedryl in time! I get migraines from my Imuran sometimes. I haven't decided whether my night sweats are from sweating out the low grade fevers or peri-menopause. I don't think these are drug related for me because I was getting the sweats even before starting any of the "super" drugs.

Jack11- Look in the gadget isle of your local Walmart. They make a special "crusher" for garlic cloves. Not expensive, but by some toothpicks as well. No....not that the garlic smell will keep you awake...silly....you'll need them to help clean the garlic crusher out! Again, don't forget to use the mineral oil first so the garlic won't burn. You'll also get immediate relief from the itch/scratch syndrome. Remicade has actually been approved as one of the better drugs on the market to treat psorasis. If it was psorasis, you may have quit Remicade for 2 bad reasons! However, my last derm did explain to me that after a major surgery it would not be uncommon for the overactive T-cells to show themselves around a surgical site as psorasis even though you may have never had it before. My abdomen is where my rash started. Being that us CDer's have overactive T-cells anyway that seemed like a plausible explanation at the time. After 2 years I am really sick of this rash though! Also, I'm stilled PO'd about having used the steroid creams for that long and didn't even need it in the first place! Again, I see my new Derm on the 25th so we will see....
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.


Jack11
Regular Member


Date Joined Oct 2006
Total Posts : 48
   Posted 2/7/2008 2:28 PM (GMT -7)   
Thanks for the information Broomhilda, will look for one. Have you tried one of the antifungal creams you can get OTC like Lamisil or something. Just wondering, seems like it would be easier than crushing garlic, unless you tried them and they do not work.

young217
New Member


Date Joined Feb 2008
Total Posts : 4
   Posted 2/25/2008 10:33 PM (GMT -7)   
Is your rash better? What have you tried? I have been suffering from a severe reaction to Humira for two months with no answers from anyone. I've seen two dermatologists, gastro guy was no help.

kimberlayn
Regular Member


Date Joined Jul 2007
Total Posts : 239
   Posted 2/26/2008 2:36 PM (GMT -7)   
I advise my clients with infants with fungal diaper rash to try Lamisil, or for Yeast causing diaper rashes try miconazole the cream for external itching due to vaginal yeast infections. External, not Internal cream. Works like a charm, maybe it could help for this. GI says I might go on humira soon, scope tomorrow to see what is what, so good to know what I might be looking forward to.
diagnosed 11/06, solving the mystery of years of on/off abdominal pain. No more "it's just a virus". 33f with 2 boys, a lovable dog, and a wonderful husband. 150 mg Imuran, bowel resection 9/07. Tapered off entocort 1/08 and feeling the effects with fatigue, pain, D.


westcoastwingnut
New Member


Date Joined May 2008
Total Posts : 5
   Posted 5/9/2008 10:20 AM (GMT -7)   
Humira is a wonder drug.  I was disabled with joint pain/damage in my hands, feet, toes, and other places.  It got to the point where I had tears in my eyes getting into the shower each morning and felt physically exhausted by the time I got to work.  Couldn't take any opiates for pain due to addiction issues, and the OTC stuff didn't help much.  Stated Humira Nov 07, and within 30 days I couldn't even point out the specific joints that had been attacked.  BTW, I studied the detail behind the cancer research and the risk factor increase is very tiny - less than living in L.A. or other smoggy cities.  Our current food supply in the USA will give you cancer before Humira does.
 
I am extremely sad however because today I am covered in hives and the itching is intolerable.  Skin rashes began in month 2 (Dec 07) and have gotten worse, slowly until now.  This last week the hives have reached an intolerable level and I just called my Dr.  I have history of excema, psoriasis etc, so I hung in there for a long time, not wanting to give up my Humira, but even dermatitis experts like me have a breaking point.  So to answer your question: Rashes began month 2, 30-45 after starting.  Mostly around anus (Pruritus ani), then inside thighs (injection site), for the remainder of month 2 and all of month 3.  Month 4 behind the knees and small of back started. month 5 inside folds of my arms started, and at the end of month 6 (April 08) my face is a mess - eyelids, lips, sides of mouth and below mouth, and under chin.  Now the itch factor in all areas previously mentioned is beyond my personal threshhold so I just called my Dr.  I'll update with the outcome, but if I have to give up Humira I will be very, very angry.
 
Good luck - if you are really itchy there is an oatmeal bath product by Aveeno that really works well.  It's expensive so if money's a little tight regular generic oatmeal works well also.  The Aveeno stuff is more powdery so it's more effective, but I guess you could by a cheap morter and pestal and make regular oatmeal powdery too!

not creative
Regular Member


Date Joined Mar 2007
Total Posts : 466
   Posted 5/9/2008 4:23 PM (GMT -7)   
I got diagnosed with Rosacea as a result of starting Humira. It got better when I started an unrelated course of flagyl and the new derm doc told me they give flagyl for rosacea so that's probably why it seemed better. He put me on a steriod cream to clear the rest up (called Finacea) and it seems to be helping, albeit slowly.

I hope Abbott or whoever is getting reports of all these side effects so they can make sure their prescribing info is accurate!
Laurenne, 23 Student @ University of California, Davis.
Dx'd w/ IBS and CD in 2002
On Humira, Strattera, Zoloft, (Multivitamin, Flax Oil, and Omega complex when I remember.)


CrohnsDaddy
Regular Member


Date Joined Oct 2007
Total Posts : 235
   Posted 5/9/2008 9:39 PM (GMT -7)   
I look like i have acne all over my forehead, and I think it's from the Humira. Also, my cheek bones under my eyes are rosy all the time. Wonder if it's gonna mean the end of Humira for me eventually.
Just trying to be a "Regular Member".
 
Entocort 9 mg/day, Prednisone 20 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.


westcoastwingnut
New Member


Date Joined May 2008
Total Posts : 5
   Posted 5/29/2008 7:37 PM (GMT -7)   

Follow up from previous post below - I had to bail on humira since rashes were taking over my body.  Pounding Prednisone right now and smearing nipple cream (best 100% lanolin on the market) all over my lips to ease the pain.

Dr wants to switch me to Embrel right away and I just got some in the fridge, but I'm gonna wait till arthritis symptoms re-appear. Been almost 2 months now with no sign of joint swelling or pain.  Try to enjoy a full power imune system for a while and not take the Embrel until I need it.

 

Good luck

 


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 5/30/2008 2:57 AM (GMT -7)   
I'm sorry, westcoastwingnut. What a disappointment.

I hope you start to feel better soon.
Co-Moderator Crohn's Forum.


ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 5/30/2008 9:59 AM (GMT -7)   
Okay, this is really starting to worry me, since I will be starting Humira in about a week and a half.  I had allergic reactions to Remicade and had the worst injection site reactions to Cimzia as anyone on the UofL hospital clinical trial.  Has anyone out there who had allergic reactions to Remicade taken Humira and NOT had any kind of rash/itching/side effects?  Thanks.

...rejoice in our sufferings, because we know that suffering produces perseverence; perseverence, character; and character, hope.   Romans 5:3-4


Pibbin
Regular Member


Date Joined Apr 2008
Total Posts : 163
   Posted 5/30/2008 1:20 PM (GMT -7)   
Zena, I had a major reaction after my 4th remicade infusion, but have had no major reactions to the Humira, aside from a reddish bruise/irritation at the injection site that usually fades within one week. Fingers crossed for you!
Dx Mild Proctitis 7/06 at age 33, Dx Severe Pan Colitis 5/07, Dx Crohn's Colitis 10/07
Failed Asacol, Lialda, 6-MP, Canasa, Rowasa, Entocort, and Remicade
On Humira since 1/08 with promising results, but can't get below 5mg Prednisone
Take Tylenol #3 as needed when not in close proximity to a bathroom.
Put back on 40mg Prednisone again during mid-March flare, ack
4/9/08 Humira dose increased to 40mg/week
Down to 15mg pred

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