"FLUCONAZOLE (in Diflucan Oral) may interact with PREDNISONE (in Prednisone Oral)
Fluconazole may block the breakdown of prednisone by the liver. If this happens, blood levels of prednisone could be increased. This may cause an increase in both the intended effect and the side effects of prednisone, including stomach irritation, facial swelling, and mood changes. If these drugs are used together, your doctor may want to monitor you closely for side effects and adjust the dose of prednisone if needed. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity."