i only went on double doses. my doc wouldnt put me up anymore than that, or any closer together. it does seem like a lot but if the doc is comfortable with it, i wouldnt worry too much.
Mary,After a few hours of reading, I have found the information regarding the info about Humira's ability to work if a patient fails on Remicade:"The message of the GAIN trial is that clinicians can use adalimumab as a treatment for patients who were previously responsive to infliximab but now are refractory to or intolerant of it. However, fewer patients will respond than those who responded to infliximab initially and only a minority will achieve remission. The medical management of Crohn disease after the patient becomes refractory to anti–TNF- antibodies is a major challenge for the inflammatory bowel disease research community." From the Annals of Internal Medicine, 19 June 2007
Also, I think you might find reading the following article helpful. It is full of statistics which makes for slow reading. I do think you will get a better understanding of the lack of response to Humira in some of those previously responsive to Remicade.
Crohn's Disease In Patients Who Fail Infliximab Therapy: What Does The Future Hold?
Best wishes to you and your daughter. ~~ Ides