Antimouse antibodies anyone??

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AKG
New Member


Date Joined Feb 2008
Total Posts : 9
   Posted 3/10/2008 9:01 AM (GMT -7)   
Hi- I have been on Remicade for about 1 1/2 years and had been taking 6MP until about 3 months ago. I had asked my MD if I could stop the 6MP because I didn't want to be taking "all the meds." I started having severe joint pain in January and have since been diagnosed w/ Rheumatoid Arthritis. My rheumy sent some lab work away and found that I have a high level of human anti mouse ab in my blood from the Remicade. I have been started on MTX and my last Remicade infusion was postponed for a month. He says the MTX will bring the anti mouse proteins down. I wonder if going off the 6MP caused me to develop the antibodies against the Remicade? I am nervous about getting my next infusion because of the possibility of having a reaction to the Remicade w/ the anti mouse antibodies in my blood! Is anyone familiar w/ the test CCP (Cyclic Citrullinated Peptide Ab) My rheumy told me that this was a test specific for RA, and that RA is the only thing that could cause it to be positive. I read online that it can be positive w/ other autoimmune diseases also confused and since I have Crohn's colitis I wonder if it could have been positive from that! Well I guess I'm just confused, I had never had so much joint discomfort before so it would make sense that it could be RA. I have been in remission w/ my Crohn's since I started my Remicade infusions so I wasn't having joint pain because of a flare up from that (I don't think). If anyone has any insight on this I'd appreciate it! Thanks, AKG
29 years old
Diagnosed w/ UC in 04' after 1st child; Diagnosed in 06' w/ Crohn's colitis; Diagnosed 2/08 w/ RA
Current meds for Crohn's: Remicade,
Current meds for RA: Prednisone 20/10mg alternate daily, meloxicam 15mg daily, MTX, Reliv' nutritional supplement daily


MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 3/10/2008 9:08 AM (GMT -7)   
MTX by shot is what worked best for me after remi reaction.
Crohn's Co-moderator

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Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 3/10/2008 4:48 PM (GMT -7)   
I would be nervous about getting an infusion too knowing that you have confirmed antibodies to the protein in Remicade. I am not certain if MTX will keep you from developing more antibodies after your next infusion. I hope that they premedicate you with an antihistamine and tylenol before the infusion to help stem any possible reaction. When I developed antibodies to the murine protein, my GI said the only way I could continue with Remicade was to take prednisone. I had to take 40 mg for two days before the infusion, 40 the day of the infusion, then tapering 30,20,10 for the three days after the infusion. It helped but I still had lots of joint and muscle pain post-infusion. After that I switched to Humira.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?
 


trickynikki
Regular Member


Date Joined Jul 2003
Total Posts : 481
   Posted 3/10/2008 5:28 PM (GMT -7)   
AKG,
I really think when I was looking up information when I had my reaction to remicade I read that people who are on immunosuppressants have less of a chance of reacting to remicade.
Also, I would be super leary to get another infusion. My joint pain became MUCH worse when I got an infusion after I started having reactive symptoms. Like, would not wish the situation on my worst enemy painful. Definitely make sure you know all your options.
~Nikki


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/10/2008 8:11 PM (GMT -7)   
As far as I know, the fact that you had to go off 6MP for a while might have increased your chance of developing antibodies. I had to go off Imuran for a whie between infusions, and guess what, I reacted the next time I had Rem.
Co-Moderator Crohn's Forum.


AKG
New Member


Date Joined Feb 2008
Total Posts : 9
   Posted 3/10/2008 10:49 PM (GMT -7)   
Thanks for all of your comments. I think I should call my MD and make sure he thinks this is safe. I am a Registered Nurse and am very skeptical of having my next transfusion on March 27th and then not seeing him until April 4th. I have a hard time making decisions for myself, but can make decisions based on my patients' needs, go figure! I am on the Prednisone but will only be taking 10mg daily at that time and am not sure exactly what the orders read as to if he is premedicating me or not. I guess I'll check all of this out 1st though. Any more input would be much appreciated, it's helpful to hear from other's that have been through similar experiences and what has worked for them. It gives me more possible options to discuss w/ my MD also!! Thanks everyone, AKG
29 years old
Diagnosed w/ UC in 04' after 1st child; Diagnosed in 06' w/ Crohn's colitis; Diagnosed 2/08 w/ RA
Current meds for Crohn's: Remicade,
Current meds for RA: Prednisone 20/10mg alternate daily, meloxicam 15mg daily, MTX, Reliv' nutritional supplement daily


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/11/2008 2:12 AM (GMT -7)   
Would it be worthwhile to work out a plan of action with your doctor, of what actions to take if you start displaying certain symptoms? You could make a simple plan for each symptom you're concerned might happen, ranging from joint pain to itchiness to rash to the really scary ones. That way, you'll have the reassurance of knowing what symptoms are ok to ignore, which ones are ok to treat symptomatically with otc meds, and which ones do require urgent medical attention from your specialist.

Best wishes to you; I hope nothing does happen at your next infusion.

I.
Co-Moderator Crohn's Forum.

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