Nausea with Pentasa

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Regular Member

Date Joined Feb 2008
Total Posts : 165
   Posted 3/13/2008 12:47 PM (GMT -6)   
Now I know why I went off the Pentasa in the past. Does any one else have this problem? I was restarted on the Pentasa with Entocort just last week and now the constant nausea is back, I remember this from before. Any suggestions on what to do to help this. Thank So Much, Kay
 I Love MY Chihuahua: Roxy
DX with CD of the TI in 2004 by colonoscpy biopsy, with partical obstructions x 3. Anemic, constant elevated ESR & WBC. Constant abd. pain and fatique.    
Meds: Vit B-12 shots monthly, zinc, multi vit, Vit E, Pentasa and now Entocort.    

Regular Member

Date Joined Oct 2007
Total Posts : 208
   Posted 3/13/2008 8:20 PM (GMT -6)   
I never have had any nausea with Pentasa and have tapered from 8 to 4 pills a day. I've read other's posts that it is just like any other drug; side-effects lessen with time. Good luck Kay!
Pentasa-tapering 1000mg/3x 1/08; Entocort 3mg/3x daily down to 1x 2/08; Percocet/Ultram for pain; Prilosec 30mg; Xanax-ANXIETY; Cymbalta 60mg
Neurontin-tapering, 600mg 3x/day
Ferrous Sulfate 325mg/daily for anemia
Azathioprine 150mg
Currently on a Low-residue diet as of 11/26

I'm so tired, when will this get better?

Regular Member

Date Joined Jan 2008
Total Posts : 87
   Posted 3/13/2008 8:47 PM (GMT -6)   
I am currently on 8 pills of pentasa a day and have been since Ive been diagnosed in January.  I don't have any nausea.  My side effects are headaches...but I had those before!! :-)
Diagnosed with crohn's in January 2008! 
Currently tapering on Prednisone and on Pentasa 1000 mg 4 times a day
On Topamax twice daily for migraines
On nexium while on the prednisone (have been previously diagnosed with ulcers)
I am 27 years old and have been married for 2 years.  I cannot wait to try to have children so I want to get this under control!!

Regular Member

Date Joined Oct 2007
Total Posts : 61
   Posted 3/23/2008 8:06 AM (GMT -6)   
I take 1/2 tab of promethazine, 25mg. for the nausea & motion sickness....seems to work wonders so far...just started, & as always need to be careful when trying new stuff...just riding in the car makes me sooooo sick, but it got much more severe with the pentasa, but that's just me, as always, everyone here is different, and has different reactions to different drugs/combos of drugs, foods, etc.
 currently rediagnosed with probable crohn's disease with IBS with d...need blood test? Had the Prometheus serology 7 blood test done, now get results 18th of this month (Mar./08)           
2 4 asacol 3x daily for UC/UP.  
Canasa suppositories, also 3x  daily,
3tsp. Donnatol elixir every 6 hours, as needed
1 20mg tab aciphex daily
1-2 depakote 3x daily for bipolar disorder
1 tramidol hcl 50mg. every 6 hours as needed for pain
2 caps of probiotics 3x daily (acidophilus)
4 caps Pentasa 2x day (500mg. ea.)

Regular Member

Date Joined Feb 2008
Total Posts : 92
   Posted 3/23/2008 9:35 AM (GMT -6)   
I've been on pentasa for a month now and budesonide for 4ish weeks and the nausea I'm having is more associated with being incredibly dizzy :-/ (the dizziness started about 2 weeks ago).

Try ginger/natural gravol? Ginger is good for nausea.
Dx: Crohn’s Ileitis as of 22/02/08
Rx: 4g Pentasa (2 pills 4 times per day)
9mg Budesonide (one capsule 3 times per day for the next 6 weeks)

Pre 22/02/08: 2.4g Asacol (discontinued due to Crohn's Diagnosis)

Veteran Member

Date Joined Nov 2007
Total Posts : 4055
   Posted 3/23/2008 9:45 AM (GMT -6)   
I don't have nausea too often but I do get dizzy. I didn't relate the dizzyness to the Pentasa, but who knows. If it really makes you naseous, maybe ask you doc to try something different.
49 yr. old female, diagnosed with Crohn's in small intestine and terminal ileum Sept-Oct. 2007. Also have IBS, and had Salmonella Dec. '07
currently taking Pentasa- 8 250mg pills per day, Cipro 1 week/month, Metamucil, probiotics

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