Serology 7 test

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Regular Member

Date Joined Mar 2008
Total Posts : 36
   Posted 3/26/2008 9:01 AM (GMT -6)   
My son (16yrs) just had blood drawn for this test that gets mailed to the Prometheus lab in CA.  Does anyone know how long it takes to get the results back and if they have been helpful?  My understanding is this test is very accurate, have you heard the same?

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 3/26/2008 11:00 AM (GMT -6)   
I don't recall how long it took, but a few days to a week I think. My Prometheus test showed UC but I have so many Crohn's symptoms (tags, abscess-fistula, etc) that I have a Crohn's DX. Here's a link for more information. Guess the accuracy is 89%.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl

Veteran Member

Date Joined Aug 2007
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   Posted 3/26/2008 11:03 AM (GMT -6)   
I believe it took about 2 weeks for my results to come back.  As far as reliability, I don't know, but I've seen the result sheet from one of mine say that they were 98% sure of the results.  There are several different tests that the Promethius lab can do and I've only had one or two of them done, so I don't know if it depends on what they are testing for or not.   
...rejoice in our sufferings, because we know that suffering produces perseverence; perseverence, character; and character, hope.   Romans 5:3-4

Veteran Member

Date Joined Mar 2005
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   Posted 3/26/2008 11:16 AM (GMT -6)   
The Prometheus tests are pretty accurate. The sensitivity is very good (i.e., if you have a positive test, it's a good indicator of disease) but the specificity is not as good (i.e., if you have a negative test, there is still a chance that the disease is there). It can be very useful in determining whether a person has IBD, and if so, what type is most likely (Crohn's or UC) - it depends on the markers found in the patient's blood. I got my results back pretty quickly, hopefully you will experience the same. Best of luck!
Co-moderator - IBS Forum

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Date Joined Nov 2007
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   Posted 3/26/2008 3:48 PM (GMT -6)   
It took me about 10 days to get the results back and it was positive for Crohn's. My doc still wanted to do a colonoscopy to confirm the results by biopsy and to see the extent of the disease.
49 yr. old female, diagnosed with Crohn's in small intestine and terminal ileum Sept-Oct. 2007. Also have IBS, and had Salmonella Dec. '07
currently taking Pentasa- 8 250mg pills per day, Cipro 1 week/month, Metamucil, probiotics

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 3/26/2008 10:14 PM (GMT -6)   
I would also recommend follow up with this Lab for anyone on 6mp, Imuran and the like at least every 4 months to check your liver tolerance of this class of drugs...they have been very helpful to me identifing me as one of those who can only take a certain dosage of this type of drug before I come toxic. Ergo...dictating my course of therapy for the long haul. Very Pleased! Very Accurate! and Fairly Prompt with Results!
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.

Regular Member

Date Joined Sep 2004
Total Posts : 152
   Posted 3/26/2008 10:50 PM (GMT -6)   
Ok here is the deal. I had a series 6 test done at my local GI's office which came back 98% positive for crohns. I went to see a better GI in Philadelphia and he repeated the Prometheus but the name was changed to series 7 and it came back negative for crohns. I recently seen a Gi at Mt. Saini in NYC and he says that the Prometheus is really not a reliable test as it is only markers of a general population...kinda like the Gallop Polls used in voting. You tel me why it came nack positive the first time and negative the second time? Remember that Prometheus Labs owns the rights to the drug Entercort which is used in the treatment of IBD. If you owned the rights would you not want the test to be more positive as to sell more drugs? If you want I can list all the markers that came back both positive and negative on both tests. Kinda funny how they changed overa 6 month time period.......

Regular Member

Date Joined Oct 2007
Total Posts : 61
   Posted 3/27/2008 6:33 AM (GMT -6)   
I too recently had this test, was quick to receive results.  I, however, am headed for my third colonoscopy in a little over 6 months...since "there were no clear markers/flags to indicate crohns, but the previous biopsies did find colitis with possibilities of crohns"....i just don't know...we'll see after this colonoscopy i'm going to have this morning....wish me luck!  good luck to all of you, and I hope that this blood test can show what needs to be found to help you all the most...oh, i've got it in rectum, two spots in colon & two spots in terminal ileum, and just beyond (intestinal)....i had always thought this was crohn's....guess not...we shall see if i'm just being procedured to death........

 currently rediagnosed with probable crohn's disease with IBS with d...need blood test? Had the Prometheus serology 7 blood test done, now get results 18th of this month (Mar./08) Ha!  Now need another colonoscopy....          
2 4 asacol 3x daily for UC/UP.  
Canasa suppositories, also 3x  daily,
3tsp. Donnatol elixir every 6 hours, as needed
1 20mg tab aciphex daily
1-2 depakote 3x daily for bipolar disorder
1 tramidol hcl 50mg. every 6 hours as needed for pain
2 caps of probiotics 3x daily (acidophilus)
4 caps Pentasa 2x day (500mg. ea.)

Regular Member

Date Joined Mar 2008
Total Posts : 36
   Posted 3/27/2008 6:40 AM (GMT -6)   
Good Luck with the proceedure this morning. Does the doctor tell you the results before you go home or do you have to wait?

Regular Member

Date Joined Mar 2008
Total Posts : 36
   Posted 3/28/2008 12:55 PM (GMT -6)   
Just got a call from the doctor. The Serology 7 test results are in, apparently the test is 98% accurate. My son, 16 years, falls in the 84% range for Crohns according to the test. The nurse felt this was high and the likelihood of Crohns is fairly certain. He goes for an upper GI on Tuesday and then a colonoscopy, but that is not scheduled yet. I haven't seen the results but it sounds like they test for several markers.

New Member

Date Joined Apr 2008
Total Posts : 5
   Posted 4/27/2008 11:23 AM (GMT -6)   
My daughter had the serology7 test and the GI doc said her markers came out high for crohns, but i haven't seen the results yet.  Just had another endoscopy and am waiting for the biopsy results.  Everything else came out poss. crohns but not a definite diagnosis.

Veteran Member

Date Joined Jan 2005
Total Posts : 8616
   Posted 4/27/2008 1:55 PM (GMT -6)   
Welcome to the forum Crohns7 !!!

I am very new to crohn's myself. I've been a member of Healing Well at the Lupus forum for a couple years though.


In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Inflammatory Arthritis, Crohns, Diverticulosis, Sjogrens

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Regular Member

Date Joined Jan 2008
Total Posts : 95
   Posted 4/27/2008 8:12 PM (GMT -6)   
Do you need to have active disease for this test???

Dx: Crohns 1987 probually had since 1982 resections in 1992 an 2002
Gallbladder removed in 1986 The list can go on and on (if you know whatI mean)
Married 25 yr with a 17yr old son

Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 4/27/2008 9:54 PM (GMT -6)   
ALI9 said...
Do you need to have active disease for this test???

The test checks several things. The parts of the test that are looking for a specific gene do not depend on your disease being active; you'll have the gene whether or not you are currently experiencing symptoms. The other parts, however, are looking for indicators of an active inflammatory response, i.e., active Crohn's symtoms. So unless you currently have active disease (or some sort of active inflmmatory response), only the genetic marker portions will come back as positive.
Just trying to be a "Regular Member".
Entocort 9 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

New Member

Date Joined Apr 2008
Total Posts : 5
   Posted 4/28/2008 5:56 AM (GMT -6)   
Does anyone know how accurate the serology 7 test is?

Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 4/28/2008 6:13 PM (GMT -6)   
They say it is something like 80-90% accurate.

I had high antibody titers for OmpT and Cbir1, especially the latter, and was (+) for Crohn's.

I am becoming a little skeptical. Because...

I have gotten a few UTI's, and from reading the scientific literature, it appears some of the same antigens picked up by Serology 7 are also present in uropathogenic bacteria (flagellin aka Cbir1, and Omp proteins). Recurrent UTI's cause a person to make antibodies. So I am wondering if my high antibody titers could be due, at least in part, to making those antibodies during recurrent UTIs, and having a terrible UTI a couple months before being tested.

July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying...
Enteral Nutrition, SCD, Omega-3 (Fish and Flax Oil), Folic Acid, Probiotics, Vitamin E, Psyllium

Veteran Member

Date Joined May 2005
Total Posts : 4219
   Posted 4/28/2008 6:53 PM (GMT -6)   
I had an off the chart crohns positive serology. Something like 300%. But a few months later I ended up w/ e-coli. I wondered if I had e-coli at the time if it would have thrown off my results. Although, I most likely did not have e-coli then.
26 Year old married female law student.  Diagnosed w/ CD 3 years ago, IBS for over 10 years before that, which was probably the CD.  I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid.  For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn.  I also have bad acid reflux and have been on PPI's since age 13.  I have been through prilosec, prevacid, and nexium.  Currently I am on Protonix in the morning and Zantac at night.  I alos take a birth control pill to allow some fun in my life.

Regular Member

Date Joined Sep 2004
Total Posts : 152
   Posted 4/29/2008 8:08 AM (GMT -6)   
This test is really not reliable. I had a positive (98% suggestive for crohns) using the serology 6 test, a year later I had the serology 7 test and it came back negative for crohns. You tell me what is wrong with the test?

New Member

Date Joined Jan 2011
Total Posts : 9
   Posted 2/23/2011 5:36 PM (GMT -6)   
i just came from a second opinion gastro appt. and he said the test is only 30% accurate for crohn's??? is that true?? he said it's more of a test for UC not crohn's...also said people without crohn's often test positive in the serology 7...can anyone out there confirm?

Veteran Member

Date Joined Feb 2009
Total Posts : 1810
   Posted 2/23/2011 6:53 PM (GMT -6)   
well, I think from the varying responses to this question, the test is somewhat controversial. On their website and in the literature, they say the ASCA and similar serology 7 tests are highly accurate. My colonoscopies and biopsies have not shown crohn's, just garden variety colitis or possibly diverticular colitis. My doctor thought if you have other auto immune issues, the tests might show a false positive. My IgG ASCA was positive.
d 1/09 with colitis sigmoid colon with some diverticular disease as well, IBS, Colon resection Nov. 2010, now in remission
inflammator arthritis, fibromyalgia, asthma, skin scleroderma, VSL#3 probiotic, Vit. D, nexium, pexeva (paxil), synthroid, cozar, advair, plaquenil, prednisone sometimes
Blood test positive for Crohn's via prometheus ibd serology panel ASCA. Positive ANA speckled pattern

New Member

Date Joined May 2013
Total Posts : 8
   Posted 5/2/2013 3:50 PM (GMT -6)   
Does anyone know if being on Prednisone will adversely affect the IBD Serology from Prometheus?

MamaCof3: mother of 15 yr old being diagnosed currently

Forum Moderator

Date Joined Nov 2003
Total Posts : 7055
   Posted 5/2/2013 6:38 PM (GMT -6)   
It should not. I would call the GI's office and ask. Also, not all insurance companies will pay for this expensive lab test. Might want to check. I know Aetna doesn't cover it. BTW, welcome to Healing Well! You posted on a VERY old thread. If you have other questions, just click on POST NEW TOPIC and ask away. That will insure that everyone sees it.
Moderator Crohn's disease, Osteoarthritis and Irritable Bowel Forums

CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, pulmonary hypertension, degenerative disc disease, asthma, severe allergy and a host of other medical problems.

New Member

Date Joined May 2013
Total Posts : 8
   Posted 5/2/2013 8:08 PM (GMT -6)   
Thanks for the welcome. Just found you guys on line while researching this overwhelmingly confusing process of my 15 yr old being diagnosed. I'm sure there will be more questions! :)
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