Sarita, can I pick your brain?

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dunny2
Veteran Member


Date Joined Jan 2007
Total Posts : 3200
   Posted 4/9/2008 10:42 AM (GMT -7)   
What would make my triglyceride levels soar?

The first time it happened I was taking 6mp. They went to over 2000. As a result I had 2 serious attacks of pancreatitis, which has
left it scarred. Eventually, after taking Tricor & Omocor my levels returned to a normal range of 200.

Then zap, back up they've gone again 1500 at the moment, but obviously its scaring me because of the pancreas situation.. But...
I haven't done anything different. My diet has always been low in fat, my weight is, at present normal, and I don't have a family
history!!

I'm so bewildered!! Is there maybe any other disease I should be looking at? I know kidneys can come into play, and I have to say
I always have high levels of protein in my urine, and often my P is frothy. Plus there is always trace blood +++, but I've put this
down to the occasional kidney stone.

I saw a nephrologist once when I was an in-patient, he was very concerned, and was talking about biopsy and stuff, but once discharged
I never heard no more.

I know I might be way off track, but I would just love some answers. I know you're busy, and I'm sorry to bug you, but if you could shed
a little light, it would be great. Thanks in advance...
Vicky

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with pancreatitis

Laughter is the brush that sweeps the cobwebs from our hearts


Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 4/9/2008 12:46 PM (GMT -7)   

I'm not Sarita, but I thought I might jump in here because I wrote a report about triglycerides a few years ago. I'm wondering if you might have one of the familial lipid disorders. Even your normal level (around 200) is considered high by US guidelines (normal is under 150, up to 199 is considered borderline high, and anything 200 or over is unequivocally high). I know you you don't know of a family history of this, but maybe some relative did pass it on to you. The hereditary conditions that can cause high triglycerides are all a bit of a mouthful, but you could google each if you are curious: familial chylomicronemia syndrome, familial hypertriglyceridemia with chylomicronemia, familial dysbtalipoproteinemia, familial combined hyperlipidemia, familial hypertriglyceridemia, and hepatic lipase deficiency.

Kidney disease can also cause high levels of triglycerides. This is not something I know anything about, barring the fact that it is a known risk factor, but if the genetic conditions are definitely ruled out, it is something you might want to consider seriously. Any chance of getting another nephrology consult?

Hope things start looking better soon.

PS: Sorry for the weird font changes. This message board does not play nicely with my voice-recognition software.


Sarita
Veteran Member


Date Joined Mar 2005
Total Posts : 2486
   Posted 4/9/2008 12:52 PM (GMT -7)   
Dunny, I'd love to help if I can. You'll probably end up helping me educate myself more than I'll end up helping you figuring it out...but we'll see where it goes. Just keep in mind that these are suggestions, I'm still a long way off from graduation, and there are so many factors that may come into play. But even with all that in mind...

The first thing you should do is get a referral to a nephrologist to follow up on the proteinuria and hematuria. Any persistent protein or blood in the urine warrants a renal work-up. You should be getting at least a 24-hour urine to check your protein/creatinine ratio and quantify the level of protein in the urine. A biopsy might be necessary but only a nephrologist would be able to properly weigh the risks and benefits of doing that.

There are some causes of "hypertriglyceridemia" (that's the medical term for high triglyceride levels) - some of those include, like you mentioned, a high-fat diet, obesity, diabetes, etc. But kidney disease can also be a factor; so can genetic diseases such as familial hypercholesterolemia, but you say that no one else in your family has had a problem like this. So you don't know anyone in your family who has had an abnormal lipid profile done?

Has your GI mentioned anything about you seeing a kidney specialist?
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Please always remember to consult your medical professional regarding your medical questions; this forum is intended to provide patient-to-patient support. Although some of us have healthcare backgrounds, we cannot diagnose or treat patients on the board.


dunny2
Veteran Member


Date Joined Jan 2007
Total Posts : 3200
   Posted 4/9/2008 4:03 PM (GMT -7)   
Writer & Sarita, may I just say thank you so much for your input, it is greatly appreciated.

Firstly, I'm unaware of any family history of either high triglycerides or cholesterol, but bearing in mind I'm 56, so my
parents, aunts, uncles and the like were probably not really screened. My father did die from a MI, but his was caused
initially from a valve problem.

Now to the kidney problem, I have had 24 hr urine collection, but that was a few years ago in conjunction with stones, it was
unremarkable, but I still continue to spill protein, but I actually gave up on the whole idea, as I became more sick with Chrohns
and now chronic pancreatitis. BUT I have to say, these triglycerides have me worried in more ways than one.

I think I will mention the nephrology consult again, although I don't rejoice in the idea....
Vicky

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with pancreatitis

Laughter is the brush that sweeps the cobwebs from our hearts


dunny2
Veteran Member


Date Joined Jan 2007
Total Posts : 3200
   Posted 4/9/2008 5:00 PM (GMT -7)   
Writer, I'm curious that you wrote a report on my very problem. Is it something that interest you, or a problem that
you're battling yourself?

Secondly, if this is something I've inherited, what can be done, other than what I'm already doing. My greatest fear is that
I should die of something so insipid....
Vicky

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with pancreatitis

Laughter is the brush that sweeps the cobwebs from our hearts


Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 4/10/2008 6:02 AM (GMT -7)   
Vicky,

If it is inherited, you're already doing all that you can do. The medications that you are on are exactly what the guidelines would recommend: a fibrate (of which TriCor is one) plus omega-3 fatty acids (that's the Omacor), in conjunction with a low-fat diet (<15% of calories from fat). I suppose you could talk to your doctor about whether it might be worth adding another lipid-modifying drug in another class, but the trouble is, the more drugs you add, the more risk of drug-induced side effects such as -- you guessed it --- pancreatitis. Frustrating, I know, that there's not more you can do to change things. However, if the high triglycerides are caused by another condition (something kidney-related, for instance), it's possible that controlling that condition will help bring them down. But I can't really helped with the kidney/triglyceride issues because my report focused more on the different medications to lower triglycerides rather than some of the rarer conditions that can cause high triglycerides.

As to why I wrote the report, as my screen name suggests, I am a writer by trade, and I've done quite a bit of medical writing. The report (all 85 pages worth!) was a work-related project. I lucked out in the genetic lottery when it came to cholesterol and triglyceride levels, so I can't apply anything I learned in that project on myself, but I did find it quite interesting.

Best,

Writer
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