Strange humira side effect, anyone else?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Pampers
Regular Member


Date Joined May 2007
Total Posts : 76
   Posted 4/11/2008 9:40 AM (GMT -7)   
Hi all,
 
I love my humira and it really is helping me, but the side effects are really painful, itchy and uncomfortable.  I inject every week.  the day after my injection I get a welt that is red and hard as plastic, about 6 inches across my lower belly on the injection site.  its also about 4 inches up and down, so basically my whole left quadrant is red and inflamed.  It also sticks out an inch from my body on that side and my pants fit tight over it to hold it in.  its very itchy and reminds me of a gigantic mosquito bite.  It also burns inthe shower if water hits it (weird right)  any one else getting this?  It goes away in a few days but with every injection the welt gets larger and more annoying.  Beleive me, its better than CD so I'm not complaining but if I can do something about it I would...any advice?
 
Thanks!!
DX with UC 8 years ago/Re-Diagnosed with Crohn's 6/26/2007
Canasa / 1 per day
Azathioprine / 100 MG Day
Lialda(new) 2 per day
Rowasa / 1 per day
Humira
 
Tried:
Asacol / 12 per day
Levaquin 1 per day
Flogyl 1 per day
Prednizone / 40 MG Day( finished taper!!!) 
Colazal/ 9 per day
Entocort/ 3 per day
 


dunny2
Veteran Member


Date Joined Jan 2007
Total Posts : 3200
   Posted 4/11/2008 9:49 AM (GMT -7)   
Sounds as though you are having an allergic reaction to something. It could be the wipes, the plastic around the pen, and of
course to the medicine itself.

I know the literature says it can cause injection site irritation, but this seem very extreme. Please mention this to your doc, or
even call the humira help line....
Vicky

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with pancreatitis

Laughter is the brush that sweeps the cobwebs from our hearts


Pampers
Regular Member


Date Joined May 2007
Total Posts : 76
   Posted 4/11/2008 10:00 AM (GMT -7)   
I saw my doc last week about it, but the lump had gone down (the appt was right before my next shot was due) so she really didnt get to see it in its full glory. I also told her my other symptoms, since I'm on the Humira study, which include a headache 3 days after the injectins and sometimes a rash on my chest. Overall, the general feeling from the doctors was if I could handle it they were okay with me continuing with the study, or if I wanted I could stop taking it and try something else. I can handle it I think since it seems to be working...I wonder though is anyone else having this and maybe taking something seperate for the side effects?

I'd still take this over a flare... but I would love to be comfortable for once. A girl can dream...
DX with UC 8 years ago/Re-Diagnosed with Crohn's 6/26/2007
Canasa / 1 per day
Azathioprine / 100 MG Day
Lialda(new) 2 per day
Rowasa / 1 per day
Humira
 
Tried:
Asacol / 12 per day
Levaquin 1 per day
Flogyl 1 per day
Prednizone / 40 MG Day( finished taper!!!) 
Colazal/ 9 per day
Entocort/ 3 per day
 


Glad Bag
Veteran Member


Date Joined Mar 2007
Total Posts : 699
   Posted 4/11/2008 10:38 AM (GMT -7)   
just curious, but how can you equate a headache three days after an injection to being related to the medication? it seems there could be lots of other causes/factors that would lead to the headache?

as for the injection site reaction though, that does sound pretty irritating, all i can say is good luck.
"I am he as you are he as you are me and we are all together!" - The Beatles

doesn't that just sound cool when you sing it?


Pampers
Regular Member


Date Joined May 2007
Total Posts : 76
   Posted 4/11/2008 10:50 AM (GMT -7)   
Hi GladBag,

I assumed it was the Humira because I never had headaches every Saturday before I started taking it in January. Now my headaches are like clockwork. I just take excedrin (I know, not really supposed to) and it goes away. Not a big deal to me but they study nurrse likes to know everything, even if I dont think its related.

It feels like a sinus headache, but I never had allergies before. The seasons are changing though, maybe its a cooincidence and I just got my first taste of seasonal allergies...but even then, I think the timeing would be less exact...

Thanks for the replies!!
DX with UC 8 years ago/Re-Diagnosed with Crohn's 6/26/2007
Canasa / 1 per day
Azathioprine / 100 MG Day
Lialda(new) 2 per day
Rowasa / 1 per day
Humira
 
Tried:
Asacol / 12 per day
Levaquin 1 per day
Flogyl 1 per day
Prednizone / 40 MG Day( finished taper!!!) 
Colazal/ 9 per day
Entocort/ 3 per day
 


princesscolon
Veteran Member


Date Joined Apr 2006
Total Posts : 733
   Posted 4/11/2008 1:35 PM (GMT -7)   
I just took my 1st dose of 4 shots 8 days ago.  I still have red spots from the injections.  I took Claritin and Zyrtec for about 3 days after the shots.  I have had headaches too.  Sounds like we are in the same spot.  I am going to take a Claritin before my next injection and see what happens.  I called a pharmacy line and they said it was normal to have a rash because of my strong immune system.  They told me next time to not use the alcohol wipes and to put ice on the site beforehand and leave the shots out 2 hours before injecting so I'll see if that makes a difference.

Diagnosed with Left-sided UC in 1995 at age 15, Prednisone, Rowasa & Hydrocort. Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Aloe Juice, Canasa, Enotcort, Colazol, Anamantle, Remicade, etc... had 1 inch deep rectal ulcer 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed w/ Psoriatic Arthritis & Fibromyalgia Current meds: Clorazepate, Lomotil,  Tylenol pm, Lyrica started 1/17/08, Flagyl 750 mgs started 4/2/08, Humira started 4/4/08


Chelle's Sick
Regular Member


Date Joined Mar 2006
Total Posts : 61
   Posted 4/11/2008 2:17 PM (GMT -7)   
Hey Pampers...

I get the EXACT same thing after my injection. I do my shot every 2 weeks. The first 6 mos. I didn't have a reaction at all. I mean, at the site of inj. as for the Humira, it has helped me tremendously! But yes, now I get a big giant (size of my hand) lump, red, hard, itchy. Just last week I bought some benadryl cream and used that on it a few times a day. It did seem to help quite a bit. My "rash" only lasted about 1 1/2 days compared to like 3 or 4. You might give it a try. I haven't tried a benadryl tablet yet but I'm sure that would help too. Best of luck to you. I know how uncomfortable it is. Drives you crazy but as you said it's better than the CD, I feel lots better than I did without it. I find myself dreading my shot, hopefully I can remain on the 2 week schedule.
Diag'd w/ Chrohn's Nov '05. Currently taking methotrexate weekly , started Humira April '07.
 
 


LynnRN
Regular Member


Date Joined Oct 2007
Total Posts : 289
   Posted 4/11/2008 5:57 PM (GMT -7)   

I take Benedryl about 30minutes prior to my injection,it really decreases the size of my "injection welt",and the itchiness.

 

Good luck :-)


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 4/11/2008 10:46 PM (GMT -7)   
If you have a digital camera, take a picture of your site reaction. Then print it out and show it to your doctor. Sometimes it is hard to tell the size of something in a picture, so you might want to hold a rule or tape measure next to your welt when you take the picture.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?
 


dragonfly137927
Veteran Member


Date Joined Sep 2006
Total Posts : 2527
   Posted 4/12/2008 3:53 AM (GMT -7)   
I would not not use alcohol to clean the site prior just maje sure it is 100% dry or mention what the pharmacy said to your doc. If the area isnt cleaned well you could get an infection. I had issues with remicade as far as headaches but with humira I only got the headaches when I used the pen as opposed to the syringe maybe since I tense up more with the pen since I cannot control the speed of the injection. Also in addition to allergy meds you may want to use hydrocortisone cream on the area before the welt starts and apply it by the directions onto the affected area
Dx with Crohn's 1987, symptoms as early as 1984.
Temp iliostomy February 2007, reversed June 2007, Ovarian cysts, migraines, allergies (incl food allergies) , oral allergy syndrome (diff than true food allergies), Asthma, Gall Bladder removed 1999, Inguenal hernia 1987
 
 
 


Jillybean1887
Regular Member


Date Joined Jan 2007
Total Posts : 56
   Posted 4/12/2008 8:25 AM (GMT -7)   
I have a Latex allergy and I have the same type of reaction.  I take Hydroxine 25mg. about an hour before and it seems to help as Benadryl does nothing for me anymore.  Good Luck.
 
Jill
Diagnosed with Crohn's Disease in 2000
Bowel Resections 6/05, 11/05 & 7/06 (removal of terminal ileum and appendix)
Humira 40mg. every week
Percocet 10/325mg
Codeine 30 mg.
Cymbalta 30 mg.
Xanax 0.50mg
Phenergan 25 mg.
Zofran 8mg.
Hydroxine 25mg.
B12 Injections monthly


Pooie1981
Regular Member


Date Joined Mar 2008
Total Posts : 274
   Posted 4/12/2008 10:49 AM (GMT -7)   
Is Humira covered by most medical plans ? If not, is it expensive?
Ulcerative Colitis Diagnosed May 2004
400mg Asacol 3 times per day.... increased to 6 400mg per day Mar.11
Asacol changed to Mesasal 500MG 3 times per day April 1
Entocort 3 pills once a day
Daily Vitamin for Women


Lynn
Regular Member


Date Joined Jan 2003
Total Posts : 492
   Posted 4/13/2008 3:07 PM (GMT -7)   
POOIE:
Humira under medicare prescription drug plans is a specialty drug and there fore must be pre-approved before they will pay. During the first stage you pay 25% which is just around $375.00 then during second stage you pay 100%, once your through the gap you pay 5% or $70.00 for two injections. without insurance the cash price is over $1700.00 for two injections.

PAMPERS:
Do you only inject into your Tummy? Have you tried your thigh or do you get the same reaction there. I am just thinking it might be more comfy for you to have the reaction on your thigh instead of your tummy where your pants ride to irritate it even more. Just curious.
Hope your doing better soon!!
Dx'd with crohn's 1983, resections 83,85 and 89 Double Strictureplasty 2005, Dx'd COPD 2000, Psoriasis 2002 and Fibromyalgia 2005.
Currently takeing Humira, Pentasa, Lomotil, Elavil, Sinemet, Skelaxin, Advair, Abuterol, Oxycodone and Xanax as needed


Aimee =)
Veteran Member


Date Joined Jun 2004
Total Posts : 1020
   Posted 4/13/2008 5:37 PM (GMT -7)   
POOIE - Humira for me is very inexpensive. My coverage just requires me to pay the top tier copay, which is $45. So, I pay $45 a box (2 syringes) and that lasts me a month.

Out of pocket, CVS wanted $3200 for a box.

You'd have to check with your coverage to find out how they do it and what your cost would be.

MBJOH
Regular Member


Date Joined Mar 2007
Total Posts : 257
   Posted 4/14/2008 5:48 AM (GMT -7)   
I agree with Lynn, try your thigh instead. I was having an irratation also when I did it in my stomach because of my pants rubbing against it and it seemed no matter where I did my shot that was wher my waistband was the next day. I originally thought the thigh hurt more when injected but now I like it better.

jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10392
   Posted 4/14/2008 12:59 PM (GMT 0)   
Pooie, coverage is based on your insurance carrier. If your policy excludes "experimental" or "off label" drugs, it wouldn't be covered because Humira is FDA approved for Crohn's, but not yet for UC.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
The information I share on this forum is based only on my own experience and study. It is important to consult your health care provider when making health-related decisions.


Pampers
Regular Member


Date Joined May 2007
Total Posts : 76
   Posted 4/14/2008 9:35 AM (GMT -7)   
Thanks everyone!!! I am so glad to hear its not just me - not that I want anyone else to go through this...I'm just happy its a somewhat normal reaction. I will do what you all suggest, try my leg, Ice it some first, and take pics of the reaction for the doctor if it continues.

I took my last shot Wednesday and today the area is almost back to normal...the redness is gone and the area feels like skin again instead of plastic. Its still a bit puffy and there are cuts on my belly from all the scratching. In two days I inject and start the cycle over - I'll update you all on how the leg injection goes.

But still I choose Humira over CD so I'm glad there are things I can try to help with the reaction and stay on the med!!!

Thank you everyone!!!
DX with UC 8 years ago/Re-Diagnosed with Crohn's 6/26/2007
Canasa / 1 per day
Azathioprine / 100 MG Day
Lialda(new) 2 per day
Rowasa / 1 per day
Humira
 
Tried:
Asacol / 12 per day
Levaquin 1 per day
Flogyl 1 per day
Prednizone / 40 MG Day( finished taper!!!) 
Colazal/ 9 per day
Entocort/ 3 per day
 


CrohnsDaddy
Regular Member


Date Joined Oct 2007
Total Posts : 235
   Posted 4/14/2008 1:34 PM (GMT -7)   
I inject in the thighs, too. I've never tried the abdomen, cause I've had such great success with the legs. Always have been a leg man...
Just trying to be a "Regular Member".
 
Entocort 9 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

New Topic Post Reply Printable Version
Forum Information
Currently it is Wednesday, December 07, 2016 5:13 PM (GMT -7)
There are a total of 2,734,354 posts in 301,204 threads.
View Active Threads


Who's Online
This forum has 151324 registered members. Please welcome our newest member, worldviews.
372 Guest(s), 9 Registered Member(s) are currently online.  Details
Tnmproject, desert bound, Wanda1225, dismissed, Huddie, Suffering34, Hilander64, LiveJoy, RachelAvila


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer