Some good news..Inflammation-induced changes in intestinal epithelial aquaporin expression

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Elite Member

Date Joined Feb 2004
Total Posts : 20552
   Posted 4/13/2008 2:33 AM (GMT -6)   
The intestinal epithelium is a layer of cells that lines the intestines forming a vital barrier between the contents of the intestines and the interior of our bodies.  The breakdown of this barrier functionally and physically contributes to the development of IBD.
Dr. MacNaughton's team has been studying the various components that make up the epithelial barrier in both health and disease.  One component of the barrier is the ability of some epithelial cells to secrete water.
The secretion of water can act to prevent the movement of bacteria into the wall of the intestine where they may trigger or prolong an inflammatory response.  The team's research program has studied the cellular mechanisims involved in the secretion of water.  Their work focuses on the specific pathways water uses to cross the epithelium during the secretory response.  They want to know how these pathways are regulated normally and more importantly, how this regulaion is altered in IBD.
It's now recognized that water transport across epithelia occurs primarily through specific water channel proteins or aquaporins.
The team of researchers has charactorized the types of aquaporins that are present in intestinal epithelial cells.  The work also shows that aquaporins are important in the movement of water that occurs during the secretory response.  The focus is now to understand how those channels might be regulated to increase or decrease water secretion.
Using intestinal epithelial cells in their experiments, imaging techniques are used to show how these proteins move in the epithelial cells when they are stimulated by various chemicals known to induce secretion.
When these experiments are complete, the next step will be to see how aquaporins move in cells that are exposed to experimental inflammatory conditions.
The work will give a better understanding of how components of the epithelial barrier are affected by or contribute to the development of inflammation.  The hope is to find ways to prevent epithelial barrier dysfunction in order to prevent flares of inflammation in IBD.
This is extreamly encouraging news from the CCFC research and with the funding period being from2006-2009 I hope by next yr they have a complete understanding of this in order to bring us many steps closer to a cure.

My bum is broken....there's a big crack down the middle of it!  LOL  :)

Post Edited (pb4) : 4/13/2008 1:38:56 AM (GMT-6)

Veteran Member

Date Joined Feb 2004
Total Posts : 6518
   Posted 4/13/2008 7:14 AM (GMT -6)   
Thanks pb4. I will stay tuned to the water channel in the hopes that they discover the secretion. Glad some doctor had an epithelia and decided to follow up on it. Maybe another barrier will be knocked down soon..
If we would read the secret history of our enemies,we would find in each mans life sorrow and suffering enough to disarm all hostility.

Veteran Member

Date Joined Apr 2005
Total Posts : 2346
   Posted 4/13/2008 1:48 PM (GMT -6)   
Oh sniper!  You are a riot!  I'm glad that you have been hanging around more lately!

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 4/13/2008 2:53 PM (GMT -6)   
Hi Thanks for the info it's good to know what ideas the scientists are looking into when it comes to IBD . lol gail

Veteran Member

Date Joined May 2003
Total Posts : 2480
   Posted 4/13/2008 6:17 PM (GMT -6)   
I wonder how/if this coincides with the defective crohn's gene that produces a protein on cells' surfaces which control the way toxins move in and out of the cells...

Not exactly biology 101, eh?

Veteran Member

Date Joined May 2007
Total Posts : 1488
   Posted 4/13/2008 9:07 PM (GMT -6)   
Thanks PB4 and good question Roni! My question is if the protein you mentioned that controls the way toxins move in & out of cells, is it not plausible that it is toxins building up in the lymphatic system that causes so much joint pain/AS/RA, etc. in crohnies? Sarita- feel free to jump in here...
Dx'd Jan'06, 1st Resection 7/06, Predinsone, Humira, Imuran, B12 injections, Nexium. Secondary conditions: Psorasis, Acne, Fatigue, Joint Pain, Lactose Intolerant, gallstones, fibroid cysts, peri-menopausal.

Regular Member

Date Joined Jan 2004
Total Posts : 121
   Posted 4/14/2008 5:14 AM (GMT -6)   
Thanks PB4, that's really interesting news. It sounds like someone's finally thinking outside the square.
I had a scope last year and there was "no sign of crohn's", but still some inflamation. I was puzzled by this and asked my Dr. neighbour, he told me that crohn's affects the lining of the bowel thru several layers, and what I was showing was "just colitis" as it was only surface inflamation. (he read the biopsy report for me).
No if only drinking extra glasses of water solved our problem(s) that would make life a breeze!

Regular Member

Date Joined May 2007
Total Posts : 458
   Posted 4/14/2008 7:56 AM (GMT -6)   
Thank you for sharing this info! Sounds promising.
Dx:  UC Proctitis 2006
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
Started Meds:  Apr 9 08 500mg 5ASA (salofalk) to ease flare.
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
Added: tumeric and probiotics.

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