More FDA progress-Cimzia

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 4/22/2008 11:19 AM (GMT -7)   
Can't help but share with others who will be as excited as I!  The FDA approved Cimzia today!  WooHoo, more progress!
 
http://www.fda.gov/bbs/topics/NEWS/2008/NEW01821.html
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl


MBJOH
Regular Member


Date Joined Mar 2007
Total Posts : 257
   Posted 4/22/2008 12:23 PM (GMT -7)   
Thank you for the information.  It sounds an awful lot like Humira.  But you would only have to do the shot every four weeks as opposed to every two weeks.  After a year of doing the Humira every two weeks I am starting to feel like a pin cushion.  But it seems to be helping so I keep doing it.

gachrons
Veteran Member


Date Joined Mar 2007
Total Posts : 4527
   Posted 4/22/2008 1:39 PM (GMT -7)   
Thanks very new read out on this drug.I have been interested in knowing about some of these drugs and didn't realize it was so new. lol gail

gachrons
Veteran Member


Date Joined Mar 2007
Total Posts : 4527
   Posted 4/22/2008 1:39 PM (GMT -7)   
Thanks very new read out on this drug.I have been interested in knowing about some of these drugs and didn't realize it was so new. lol gail

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 4/22/2008 1:54 PM (GMT -7)   
i am pretty sure there is someone on the forum who was (until they approved it) a clinical trial patient. She (I think she) had good results. Yes, a lot like Humira but (I will quote to be accurate)

"Cimzia is the first and only PEGylated anti-TNF (Tumour Necrosis Factor) antibody. Cimzia retains the potency of the original antibody without the possible cytotoxicity mediated by the Fc portion present in conventional anti-TNFs."

I don't really understand pharmaceutically what "PEGylated" means, but I do know it's a different structure than Remicade and Humira. Maybe the person whose had success in the trial can explain?
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl


FallColors
Veteran Member


Date Joined May 2007
Total Posts : 1220
   Posted 4/22/2008 2:19 PM (GMT -7)   
I was just googling and found that there is some dispute over the real effectiveness of the drug versus the risks.
http://www.emea.europa.eu/pdfs/human/opinion/Q&A_Cimzia_14549708en.pdf

I am allergic to Remicade and Humira and would love to find a new drug that acheived the same (or better!) results and didn't send me into hives or cardiac arrest. I hope the folks with experience will chime in soon!

FYI -- According to Wikipedia "PEGylation is the a process of covalent attachment of poly(ethylene glycol) polymer chains to another molecule, normally a drug or therapeutic protein"

LittleL
New Member


Date Joined Apr 2008
Total Posts : 6
   Posted 4/22/2008 6:07 PM (GMT -7)   
I was in a clinical trial similar to the anti-tNF drug you are discussing. Immunemodulators are scary. Yes, they may work. But they modify your immune system. It has been a couple of years since the study and I still get vicious sinus infections (which I never had before the study). Also, the risks are great. I'm a nursing grad student and am taking Pharm classes. One of the things I learned (and is no surprise) is that you don't want to rush to take a new med. The fourth phase of medication formulation is where they release it to the public...that's when you may see how it actually may affect us. I know desperation may cause us to look to drugs that are helpful (yet toxic), but keep the faith and trying to find healing.

Crohn'snme
Veteran Member


Date Joined Feb 2007
Total Posts : 734
   Posted 4/22/2008 6:53 PM (GMT -7)   
Just thankful they are continuing the path to look for more ways to treat this disease. Thanks for sharing.
New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, December 09, 2016 12:22 PM (GMT -7)
There are a total of 2,735,433 posts in 301,303 threads.
View Active Threads


Who's Online
This forum has 151408 registered members. Please welcome our newest member, ChristineMdic.
322 Guest(s), 9 Registered Member(s) are currently online.  Details
DBwithUC, suebear, FearBug, LG13, Faustmann, ChickenArise, Tim Tam, rcmark, tommyc


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer