Turning out to be a very complicated case

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PV
Veteran Member


Date Joined May 2006
Total Posts : 1177
   Posted 4/24/2008 2:07 PM (GMT -7)   
As you guys know, in the continuing saga of my husband's hospitalization, he was originally admitted with a diagnosis of Ulcerative Proctitis and a c-diff infection. They treated the c-diff infection, but since he still had problems, did a colonoscopy and discovered that he probably has Crohn's not UC. Well, they put him on 120mg IV solumedrol and got his first remicade infusion on April 10th. He was starting to make small baby steps forward - his pain abated, his stool quality was very very slowly improving, no blood.

However, on Tuesday, his stool quality went down, and he started having stomach cramps again - bloody diarrhea that was much looser than the days before, and he started having some stomach cramping. The GI decided to test him again for any infections, just to be on the safe side, and the c-diff toxin assay has come back positive!

He's still taking 1000mgs of vancomycin every day along with the IV solumedrol. Also, before the test results came back today, they gave him his second Remicade treatment. The infectious disease doctor and his GI are going to consult and figure out what to do about his case, in terms of the c-diff infection. It makes more sense now why all of a sudden on Tuesday he took a turn for the worse - however, I'm not sure what else can be done about his c-diff infection.

I hope he doesn't end up having to get his colon removed to get rid of the c-diff infection. He's already taking Florastor every morning and evening to help battle c-diff. I'm really astonished that he's tested positive for c-diff again while he's still on the best antibiotic they have for c-diff.

Any advice? What should we do? Is the c-diff coming back because his immune system is severely compromised with the IV solumedrol and the Remicade? Shouldn't the antibiotics be able to keep c-diff at bay?

Any comments, support or help will be greatly appreciated. We are both at wits end, and the doctors seem just as bumfuzzled about all of this as we do. Please help.

PV
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff
Currently in hospital for past month
Canasa, Lialda, Vancomycin, Colestipol, Elavil, IV Solumedrol 120mgs, Remicade (1st infusion April 10, 2008), FloraQ, FloraStor, Morphine Time release for pain


apalaura
Regular Member


Date Joined Jul 2007
Total Posts : 53
   Posted 4/24/2008 2:12 PM (GMT -7)   
I had c-diff last year with relentless D for about 5-6 weeks. I was on Flagyl-IV and vanco-oral. Flagyl IV for 2 weeks, 2 more weeks after hospital stay and vanco for a total of 7-8 weeks. I did finally get better, but it took some time. The infectious DR's told me C-diff has become more virulent in recent years.
Dx'd 5/07, azasan, florastor, caltrate, fish oil, cod liver oil

Post Edited (apalaura) : 4/24/2008 3:16:10 PM (GMT-6)


FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 4/24/2008 4:45 PM (GMT -7)   
There have been posts on here in the past about human fecal infusions to treat C-Diff. Hopefully someone will come along that can link to that post or to an article about it.
26 Year old married female law student.  Diagnosed w/ CD 3 years ago, IBS for over 10 years before that, which was probably the CD.  I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid.  For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn.  I also have bad acid reflux and have been on PPI's since age 13.  I have been through prilosec, prevacid, and nexium.  Currently I am on Protonix in the morning and Zantac at night.  I alos take a birth control pill to allow some fun in my life.
 
 


FallColors
Veteran Member


Date Joined May 2007
Total Posts : 1220
   Posted 4/24/2008 4:46 PM (GMT -7)   
Hi PV,

I'm concerned about your husband and you! I'm sorry to hear it is back. Unfortunately, one of the easiest ways to get c-diff is being in a hospital! I'm praying it was caught very earlier and this is just a brief setback. It sounded like he was geting so much stronger. I'm hoping that because he is stronger, he will be able to fight the infection and it won't knock him quite so low this time.

Sometimes it is two steps forward, one step back -- but you are still making progress!

Take care!

poobah
Regular Member


Date Joined Dec 2006
Total Posts : 136
   Posted 4/26/2008 3:51 PM (GMT -7)   
other options to help with a bad c diff infection include adding a second antibiotic, by mouth (prefereably, just like the vanc) or IV (only if you must), or. . . drum roll. . . stool transplant.

im not making that up. we've done it at the hospitlat where i work, there are other case reports too. great results for someone who was desperately ill (about to need colectomy kind of sick).

find and test donor (family member usually) for sommunicable diseases. obtain poo. mix it with water, blend. insert via enema.

FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 4/26/2008 5:07 PM (GMT -7)   
that is what I was referring to when I said "human fecal infusion".
26 Year old married female law student.  Diagnosed w/ CD 3 years ago, IBS for over 10 years before that, which was probably the CD.  I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid.  For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn.  I also have bad acid reflux and have been on PPI's since age 13.  I have been through prilosec, prevacid, and nexium.  Currently I am on Protonix in the morning and Zantac at night.  I alos take a birth control pill to allow some fun in my life.
 
 

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