Difference between 6mp and Imuran

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Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 4/25/2008 5:16 AM (GMT -6)   
Can somebody please explain or send me a link with detailed information about the difference between azathioprine ( Imuran ) and 6mp .. Im sure i have read somewhere that the body has to do less with one of them .
I have been on aza for a few months and my liver ALTs shot up with just a small dose of 50mg-75mg and i was told to stop taking it , but im keen to try anything and everything as a maintenance medicine . I am hoping the doc tells me i can try 6mp instead , or maybe it is too similar to azathiprine ?

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 4/25/2008 7:31 AM (GMT -6)   
Imuran and 6mp are the same drug and azathiprine is the generic to Imuran.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
Also diagnosed with Osteoarthritis and Rheumatoid Arthritis

Veteran Member

Date Joined Feb 2007
Total Posts : 1010
   Posted 4/25/2008 8:05 AM (GMT -6)   
I don't think they are exactly the same. Azathioprine is the generic form of imuran, but I think imuran and 6-mp are metabolized differently, tboth act as an immune suppressant.

30+ years living with Crohn's.

Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 4/25/2008 8:10 AM (GMT -6)   
thanks ... i have since read a tiny more about it and it seems azathioprine gets broken down into mercaptopurine . But thats as far as they go in explanation .
Im hoping i can try 6mp and it wont have the same effect on my liver that aza did !!
thanks all

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 4/25/2008 11:31 AM (GMT -6)   
They are not the same drug. They both break down into 6-mp in the system, is what I understand, but AZA is a difference delivery mechanism.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl

Veteran Member

Date Joined Mar 2007
Total Posts : 1018
   Posted 4/25/2008 4:28 PM (GMT -6)   

Imuran (azathioprine) is converted by the liver into 6-MP.

Some people can tolerate one better than the other.


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