Difference between 6mp and Imuran

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 4/25/2008 4:16 AM (GMT -6)   
Can somebody please explain or send me a link with detailed information about the difference between azathioprine ( Imuran ) and 6mp .. Im sure i have read somewhere that the body has to do less with one of them .
I have been on aza for a few months and my liver ALTs shot up with just a small dose of 50mg-75mg and i was told to stop taking it , but im keen to try anything and everything as a maintenance medicine . I am hoping the doc tells me i can try 6mp instead , or maybe it is too similar to azathiprine ?

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 4/25/2008 6:31 AM (GMT -6)   
Imuran and 6mp are the same drug and azathiprine is the generic to Imuran.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
Also diagnosed with Osteoarthritis and Rheumatoid Arthritis

Veteran Member

Date Joined Feb 2007
Total Posts : 1010
   Posted 4/25/2008 7:05 AM (GMT -6)   
I don't think they are exactly the same. Azathioprine is the generic form of imuran, but I think imuran and 6-mp are metabolized differently, tboth act as an immune suppressant.

30+ years living with Crohn's.

Regular Member

Date Joined Feb 2008
Total Posts : 42
   Posted 4/25/2008 7:10 AM (GMT -6)   
thanks ... i have since read a tiny more about it and it seems azathioprine gets broken down into mercaptopurine . But thats as far as they go in explanation .
Im hoping i can try 6mp and it wont have the same effect on my liver that aza did !!
thanks all

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 4/25/2008 10:31 AM (GMT -6)   
They are not the same drug. They both break down into 6-mp in the system, is what I understand, but AZA is a difference delivery mechanism.
--39 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--stuck on methylprednisolone, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-year-old girl

Veteran Member

Date Joined Mar 2007
Total Posts : 1614
   Posted 4/25/2008 3:28 PM (GMT -6)   

Imuran (azathioprine) is converted by the liver into 6-MP.

Some people can tolerate one better than the other.


New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, October 17, 2017 2:37 PM (GMT -6)
There are a total of 2,883,334 posts in 316,377 threads.
View Active Threads

Who's Online
This forum has 157502 registered members. Please welcome our newest member, robert ford.
498 Guest(s), 15 Registered Member(s) are currently online.  Details
Lapis_29, Jasperilla, Dahlias, theruiner24, countess18, Gemlin, getting by, Brook58, Dave Here Now, SaraOnThisSite, Sono, Blu's Mama, xy123, Mb244, iPoop

Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest

©1996-2017 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer