I was so anxious to start it, too, but it was a piece of cake. Really.
The only side effect I had was some hair loss that wasn't noticeable to anybody but me. I did not take premeds, my GI at the time felt like overmedication was a problem and only those that showed a need for premeds got them. I never did need them and am thankful for that - it allowed me to work during the infusion, drive myself home, or return to class or work afterwards. The Benadryl knocks me out.
IMO, there are serious side effects to every drug. They are rare with Remicade but you are given the med while near a doctor just in case and heavily monitored. They will do regular labwork, too, to keep an eye on things.
After 2.5 years on it, I did build antibodies to it. It just stopped working and I started to flare up. Then I reacted at one of my infusions. 2 Benadryl, stopping the med, and taking a break stopped it. We were able to complete it just slower than usual.
I ended up admitted by my PCP thanks to a huge flare and was assigned a GI in the hospital. He gave a treatment, I reacted again. He decided that I probably had grown antibodies to the drug, which was making it not help anymore and causing the reactions.
So I moved to Humira, which has been great as well.
I loved Remicade. It gave me my life back for 2.5 years. I saw results within 2 infusions and was living symptom free a month after starting it.
Obviously for me, I flared when off it so who knows if I was ever truly in remission. At the time my GI warned against restarting but others have been able to restart and the studies are always changing.