Asacol side effects

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New Member

Date Joined Jan 2008
Total Posts : 5
   Posted 4/29/2008 11:03 AM (GMT -6)   

Hello.. I'm wondering if anyone else has experienced terrible side effects with Asacol?


I was on Lialda for 9 months but had to switch to Asacol due to insurance change. After being on Asacol for a short time I was suddenly very fatigued and weak, having leg cramping and the worst joint pain in my knees I have ever felt. After 3 months of this, I took myself off Asacol (Big "no no" I know) But all side effects were gone once I was off it.


I have an appointment soon with my GI to go over what we are doing next and was just wondering what the next step was for others who could not tolerate Asacol.



BTW, I don't have an official DX but inflammation in the cecum. Colonoscopy last week showed a reduction in the inflammation by more than half, so I believe the mesalamine was working.

Regular Member

Date Joined Nov 2007
Total Posts : 50
   Posted 4/29/2008 11:23 AM (GMT -6)   
 After being on Asacol for 2 weeks, I awoke one morning and could BARELY walk, my knees and calves hurt so bad I could hardly walk across the room.  My dr. tool me off and I tried Imuran.  After 3 weeks on it, I felt like I had a horrible flu with high fevers-it was affecting my liver.  I am now on Humira injections1 every other week.  So far its been okay, but its not working as well as the loading dose did.  I don't know where I'll go from here if Humira doesn't work.  Good luck to you!

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 4/29/2008 12:16 PM (GMT -6)   
I have taken Asacol for years, but have had no side effects at all.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.

Melissa H
Regular Member

Date Joined Mar 2008
Total Posts : 85
   Posted 4/29/2008 12:19 PM (GMT -6)   
The only side affects that I can pinpoint to the Asacol, for me, were (are) hair loss and dry mouth. The rest of the potential side effects they warn of with Asacol are all symptoms with Crohns -- so who knows?! Good luck with finding the drug (or supplements!) that will work for you :)
30 year old wifey and mom to 3 little girls, 2 dogs, and 2 ratties and working full-time outside of the home...nap anyone?
Suffered with symptoms for 12 years, dx Crohn's-Colitis 11/2007.  Taking Asacol, Omeprazol, Rowasa, Bentyl. Flaring off and on and trying to avoid steriods.  I've started a regimen of supplements from my naturopath to see how that helps: RF Plus (rebuilds GI mucosa), Similase (digestive enzyme), Cortine (supports adrenal function), Pregnenalone (hormone, helps memory and energy), and Vitamin B injections. 

Regular Member

Date Joined Oct 2006
Total Posts : 87
   Posted 4/29/2008 5:54 PM (GMT -6)   
I took Asacol and had the worst knee pain.I thought at first that maybe i blew my knee out because it hurt so bad.I even had the physical therapist at work wrap it.Then I started having extreme headaches and they ended up saying that my body couldn't break down the drug and I was basically overdosing on it.Once i was off of it long enough to leave my system everything got much better.
dx in oct 2006
entocort ec 9mg 1xday
remicade 10mg per kilo every 6-8 weeks
phenagren every 8 hours
dycyclomine 20mg 3xday
iron 325mg 2xday
calcium supplement
hydrocodone/apap 5mg/500mg 1-2 tabs every 4-6 hours
hydroxyzine 25 mg 1 tab every 4-6 hours
glycopyrrolate 2 mg every 8-12 hours

Regular Member

Date Joined Mar 2008
Total Posts : 274
   Posted 4/29/2008 6:21 PM (GMT -6)   
I was on Asacol from 2004-2008 and it kept me in remission until March of this year. I didn't have any symptoms or side effects.
Ulcerative Colitis Diagnosed May 2004
Sulfasalazine 500MG 4 times per day
Prednisone 5MG 3 per day for next 10 days
Daily Vitamin for Women and Folic Acid

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