I have gotten 2 doses, tonight will be my 3rd. Both times, I had a huge red welts the next morning when I woke up. I took Claritin for several days and it took at least a week for it to clear up. The first time it happened, I called my pharmacy help line that specializes in Humira, they said it is totall normal and to take Benadryl or Claritin beforehand. A few days later, I went to my GI and showed him (and they were smaller by then) and he was like, oh no and that I was only the 2nd person he saw who had that. So the next time, I used the ice pack 1st, took Claritin, put benadryl cream on after, and I got bigger welts the next mornning. The doctor said if I can stand the itching and burning, then fine, continue taking it, just make sure my throat doesn't close up, she said that taking 4 shots, and then 2, was a lot at once, so maybe once I start doing just one, then the reaction would lessen. I guess it's not good that you never had a reaction at the spot and now you are having one.
Photo of my welts last time: