Imuran/Azasan = Sensitive teeth?

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Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 5/9/2008 11:43 PM (GMT -6)   
OK, this is weird for me.. I'm 41 years old, and I have never had a cavity. No fillings, nada. My bowels may be a mess, but I've got great teeth. :)
I've never had a tooth ache, or even a sensitive tooth. Then a couple weeks ago, my teeth started getting sensitive. So I bought some Sensodyne toothpaste, which hasn't helped.
I'm at 2 months and 2 weeks since I started taking Imuran/Azasan. Has anyone else experienced sensitive teeth from 6mp/Azasan/Imuran? It's driving me crazy! My teeth are soooo sensitive... hot, cold, warm, cool, sweet, pretty much everything makes them hurt.
Anyone else??
Just trying to be a "Regular Member".
Entocort 9 mg/day, Prednisone 20 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

Veteran Member

Date Joined Oct 2004
Total Posts : 3042
   Posted 5/10/2008 9:19 AM (GMT -6)   
Hi, I have been on Imuran for almost 5 years and have no teeth problems from it. I would call your GI doctor and let your doctor now about the problem.
Hi, I am teddybearweiser, I am a male.
I was diagnosed with crohns disease when i was admitted to the hospital

in 1992, in Jan of 1993 I was back in the hospital for surgery for my crohns. I had part of my right colon resectioned with ilecolonstomy.

My GI doctor has me on Asacol, Dicyclomine,Imuran,Celebrex and Remicade. B-12 injection once a month.
Also diagnosed with Osteoarthritis and Rheumatoid Arthritis

Forum Moderator

Date Joined Nov 2003
Total Posts : 7055
   Posted 5/10/2008 3:54 PM (GMT -6)   
Your signature says you are on prednisone. Prednisone can cause sensitive teeth. Also, as we age, the acidic properties of some foods and liquids, and long-term use of certain mouth washes makes minute pores in the dentin causing the teeth to be more sensitive.

My teeth became very sensitive from damage caused by multiple autoimmune issues. My dentist prescribed a prescription strength fluoride gel that I apply. This as fixed the problem.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, small fiber peripheral neuropathy, avascular necrosis, diffuse connective tissue disease, Sjogren's Syndrome ?

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 5/10/2008 6:42 PM (GMT -6)   
Hi I have sensitive teeth too and thought it was the nicorette gum but I did come off Imuran a few weeks ago . I also find I am putting alot of pressure on my teeth at night when trying to sleep . I find it hard at times to be always wandering what is causing what .I used sensitive toothpaste when it bothers me alot. Hope you can get this problem better for you. lol gail

Veteran Member

Date Joined Feb 2007
Total Posts : 734
   Posted 5/10/2008 10:21 PM (GMT -6)   
I had sensitive teeth while on imuran. Imuran was a horrible drug for me.

map lady
Regular Member

Date Joined Feb 2008
Total Posts : 154
   Posted 5/12/2008 10:43 AM (GMT -6)   

It could definitely be from the predinsone.  My GI and regular doctor said they hadn't heard of it, but other people at work with UC and Crohn's both complain of tooth problems from prednisone.  My dentist was very familiar with it also and gave me a super fluoride treatment to help, it wasn't very helpful until I got to less than 20mg of the prednisone though.

The dentist even said that the prednisone actually physically damages and weakens your tooth enamel, and the loss of enamel is what makes your teeth hurt.  Not sure if your dentist will have it or will have heard of it, but there's a product called "MI Paste" that can also help with your enamel, you just rub it on your teeth a couple times a day.  They also use it for cancer and aids patients to help with tooth problems caused by treatments for those diseases.  If you want/need more info about that product I can find the box at home and post more, I think there is a website about it and so on.

Regular Member

Date Joined Oct 2007
Total Posts : 235
   Posted 5/12/2008 11:41 AM (GMT -6)   
Thanks for the info, everyone. Come to think of it, the whole sensitive teeth thing came on while I was in a CD flair, so I was taking 40 mg of pred for two weeks, then 30 for two weeks, and now I've been on 20 for two weeks, and the sensitive teeth thing has gotten better over the last couple days. Don't know if it's from the lower pred dose, or if the Sensodyne is finally working.
I'm soooo happy to have that flair under control. Not only under control, but full remission now. I think that the Humira and Azasan have had enough time to finally make a difference. My current cocktail of 20 mg pred, 100 mg Azasan, bi-weekly Humira, 9 mg Entocort, and 4 gm of pentasa really seems to have knocked my CD to the mat. My wife still thinks it's weird to hear a "woo hoo!!" coming from the bathroom. ;)
I'm now getting as good of relief from 20 mg of pred as I was at 40 mg of pred. I really think the difference is the Azasan starting to kick in. Once I hit the four month point on Azasan, I'm going to taper all the way off the pred and see if the Azasan, Humira and Pentasa are enough to stay in remission. This is my Doc's suggestion, btw, as he doesn't like to keep people on pred if there are other viable alternatives that are as effective.
Just trying to be a "Regular Member".
Entocort 9 mg/day, Prednisone 20 mg/day, Pentasa 4 gm/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.

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