I think if I was in that case, I would make a deal with myself. I would try the humira first, but if you don't notice any fairly significant improvemnt after awhile...then I'd go under the knife. Hopefully they only have to remove that rather small portion of your intestines, and hopefully you'll be 90% symptom free afterwards. I had a resection, and they are totally worth it if you are that bad off. Probably the most difficult part is being able to take 2 months off work or school to do so. You'll probably be in the hospital for 2 weeks, then after you'll basically be recouperating at home regaining strength for another month and a bit until you are totally normal again. So you'll be able to return to most jobs after 2 months, or if you work at home on a computer, then 1 month or so. The pain of the surgery is no where near the long term struggles of constant crohn's symptoms if they are bad enough. Not to mention, even as your recovering in the hospital, you'll feel releived the surgery is over, and good days are ahead. Thats how it was for me. I got about 3-4 years of feeling fantastic afterwards. Of course, the only bad thing is that once they cut it out, you never get it back.