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Mike W
Regular Member


Date Joined Aug 2006
Total Posts : 89
   Posted 5/18/2008 10:12 PM (GMT -7)   
I've been doing reading on 6Mp here in the forum, but I find that often people don't mention what dose they are on. I am taking 75mg right now and considering going to 100mg. I get blood tests right now and my white count is normal, hemo is 110 and iron is almost 0 due to bleeding. I can't tolerate iron pills. I started 20mg prednisone today.

Anyway, I remember there used to be an ask the doctor section on the CCFA website and he used to say that the therapeutic dose for 6MP is 1.5 mg/kg for 6MP and 2.5mg/kg for Imuran. I am about 62kg, so that would put me at 100mg.

Does this does sound reasonable? Seems to me that most times when people do mention their dose it's 50mg of 6MP or 50 to 100 of Imuran.

thanks!
Diagnosed in 1999.
No surgeries.

Age : 31

Currently on 75mg 6mp , 20mg prednisone and probiotics.


Irish_Mom
Regular Member


Date Joined Apr 2007
Total Posts : 385
   Posted 5/19/2008 7:42 AM (GMT -7)   

Hi Mike,

My son is on 50 mg of 6MP even though his dose should be 100 mg taking his weight into consideration. He did go up to 100 mg at one point, but his liver started complaining, so he was dropped back down to 50 mg. His bloodwork through Promethius showed that 50 mg was okay for him.


Terri
 
_________________________________________________________________________________
Breast Cancer at 37; bilateral mastectomy with reconstruction.
Colon resection 2004; Sub-Total colectomy September 2007 for colonic inertia - didn't work.
Son (HLA B27 positive) diagnosed with Crohn's at 17 (now 21). Taking Asacol and 6MP with Prednisone and Rowasa added during flareups. Recently diagnosed with ankylosing spondylitis - now on Humira.
Husband HLA B27 postive with ankylosing spondylitis and psoriatic arthritis.


LBJ
Veteran Member


Date Joined May 2005
Total Posts : 511
   Posted 5/19/2008 7:56 AM (GMT -7)   
6pm dosage all depends on your weight. 

dustspeck
Veteran Member


Date Joined Sep 2007
Total Posts : 565
   Posted 5/19/2008 8:55 AM (GMT -7)   
i actually started out at 25mgs, then 50, 75 and we are looking to 100mgs next for me. i need to get some health insurance things figured out before i start my bloodwork so i am staying at 75mgs for now. i weigh 106 lbs (48 kgs if i am correct?) but my gi said my body seems to metabolize the 6mp rather quickly and i am still on the low end of the therapeutic spectrum. has your gi done a tng level to see if you are at a therapeutic level yet?
.: stephanie :.
32 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits


ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 5/19/2008 9:34 AM (GMT -7)   
I'm on 50mg 6MP currently but my doctor just did a Prometheus test last week to see if I'm even at a therapeutic dosage or not.  If not, we will either up it or stop it altogether, due to the risks associated with taking it and a biological at the same time.  BTW, I weigh right until 150. 
...rejoice in our sufferings, because we know that suffering produces perseverence; perseverence, character; and character, hope.   Romans 5:3-4


Mike W
Regular Member


Date Joined Aug 2006
Total Posts : 89
   Posted 5/19/2008 9:40 AM (GMT -7)   
My doctor did to a test to see how I metabolize it and he said I'm int he therapeutic range, but he said he's comfortable going higher as well.
Diagnosed in 1999.
No surgeries.

Age : 31

Currently on 75mg 6mp , 20mg prednisone and probiotics.


dustspeck
Veteran Member


Date Joined Sep 2007
Total Posts : 565
   Posted 5/19/2008 11:00 AM (GMT -7)   
i've been on 6mp for a little over 6 months now. it has helped but i am still not in remission (whatever that is!). i am better since being on it, but i still take percocet for pain and still have d 8-10 times on a bad day. he is a bit concerned putting me on a higher dose but this is our last attempt at 6mp. hope you have good luck with it!
.: stephanie :.
32 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits


Mike W
Regular Member


Date Joined Aug 2006
Total Posts : 89
   Posted 5/19/2008 11:18 AM (GMT -7)   
Ya that would put you at 2mg/kg, which is probably around the upper limit. Don't give up on it though, maybe it will put you over the top and into remission. Perhaps another drug will have to put you in remission while the 6MP can keep you there.
Diagnosed in 1999.
No surgeries.

Age : 31

Currently on 75mg 6mp , 20mg prednisone and probiotics.


dustspeck
Veteran Member


Date Joined Sep 2007
Total Posts : 565
   Posted 5/19/2008 11:29 AM (GMT -7)   
thanks for the words of encouragement :) i am certainly keeping my fingers crossed!
.: stephanie :.
32 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits


Brig
Regular Member


Date Joined Apr 2008
Total Posts : 33
   Posted 5/19/2008 5:49 PM (GMT -7)   
I started on 50 mg 6MP and went up to 75mg after four weeks. I get blood tests done each fortnight. I weigh about 55kg so 100mg sounds reasonable for you.

Mormor Vicky
Veteran Member


Date Joined Mar 2007
Total Posts : 684
   Posted 5/19/2008 8:54 PM (GMT -7)   
So now I know my doctor screwed up and didn't know what he was doing.  I went from 50 to 100 to 150 and within a few weeks was in the hospital for 11 days with bone marrow suppression.  I always did have a fear of this drug, now I know why.  By the way he is no longer my doctor.
Vicky / 48 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
 
Daughter (27) also has Crohn's since she was 12.
 
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor


Mommy pooh
Regular Member


Date Joined Apr 2008
Total Posts : 131
   Posted 1/23/2009 8:19 PM (GMT -7)   
I was wondering about the weight to dosage of 6MP and found this thread from last May. I am interested in what everyone's dose and weights are. I have lost 35 pounds since starting 6MP and would like to drop down to 50mg but my doctor won't hear of it. My Promethus test showed high risk to liver and low effectivness. My liver enzymes are still fine so he says we don't need to reduce. It did put me in remission but I'd rather take the smallest amount possible to stay in remission. I'd love to know other's weights and dosages.

5 foot 4 inches tall
130 pounds
75mg 6MP
  • 26 years old, married, Stay-at-home Mommy to 2 year old daughter 
  • Ulcerative Colitis since Sept. 2004
    • 1st flare Sept-Nov 2004
    • 2nd flare Aug. 2007-July 08 
  • Currently taking:75mg 6MP, 4 Lialda, Loestrin 24, Allergy meds., Maxalt for migraines and allergy shots once a month 
  • Past meds: Pred., Entocort, Dipentum, Asacol, and Canassa
  • 10/6/08 Found a 1cm kidney stone in right kidney.  Had the stone blasted and passed the fragments.

 


FallColors
Veteran Member


Date Joined May 2007
Total Posts : 1220
   Posted 1/23/2009 9:45 PM (GMT -7)   
Hello,

Weight is just a general target. The real test is how efficient your body is at metabolizing the drug. Your rate of metabolism determines how much you need to take in order to get in the therapeutic dose range. I am taking less than 1.5 mg/kg but I am in the therapuetic dose range.
Diagnosed early 2007 with rectal Crohn's.  Several peri-rectal abscesses and two fistulas with setons.  Allergic to Remicade and Humira.  Currently on 6MP.


cayer
Regular Member


Date Joined Jan 2009
Total Posts : 76
   Posted 1/23/2009 10:57 PM (GMT -7)   
I am 55kg and am on 100mg a day.
26yrs old Diagnosed in 2000 with Crohn's surgery for perianal abscess and fistulas
currently on Imuran 100mg
Worst pain equal to child labor was after eating home made Granola...i can still hear the screams.


inflamed
Veteran Member


Date Joined Nov 2005
Total Posts : 1340
   Posted 1/24/2009 8:32 AM (GMT -7)   
FallColors has it. Weight gives you the range to start from, but the blood work really shows if that is right for you. I was on 75mg most of the time (130lbs). They attempted 100mg for a while, but didn't like the blood work results.
Hoping to stay in remission after the birth of a healthy baby girl. On Pentasa during my pregnancy, went med-free 2 months to nurse (stupid), but back on Pentasa and still nursing.

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