Biopsy report - giant cell....What is that?!

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Apr 2008
Total Posts : 30
   Posted 5/19/2008 4:51 PM (GMT -6)   
I picked up my biopsy report today from 2000 when I was first diagnosed and it says there was an ill-defined granuloma with histiocytes and an occasional giant cell noted. What are these things? Has anyone had this come back on their report? I googled it and couldn't find much. Thanks for any help!
30 years old~ Diagnosed in 2000 with Crohn's~ Currently taking 3000 mg Pentasa, Prednisone, and Bentyl.

Regular Member

Date Joined Feb 2008
Total Posts : 91
   Posted 5/19/2008 6:25 PM (GMT -6)   
Hi Anna,

All I can do to help is to pass you these sites:

as for the giant cell I can't help you.

CD diagnosed 34 years ago
Stem Cell Transplant may be back on
Lap-assisted Ileocolic Resection- February 2008
Ankylosing Spondylitis
Back on Prednisone - I hate it
Ranitidine HCL 
Prednisone 1% (eye drops)
Maxidex  (eye ointment)
Homatropine 5% (eye drops)
B12, Folic Acid, Vitaman D, Calcium

Regular Member

Date Joined Dec 2007
Total Posts : 298
   Posted 5/19/2008 6:34 PM (GMT -6)   
Giant cells are basically macrophages. Macrophages are the immune cells that "eat" foreign particles like bacteria to neutralize them. In a nutshell...when you get a long-standing inflammatory response, the macrophages fuse together, and it becomes one enormous macrophage with multiple nuclei, aka a giant cell. This is seen in tuberculosis infection, which is a type of chronic granulomatous inflammation, similar to Crohn's disease.

Here's something from Wikipedia.
Add: It just means you had a chronic inflammatory process going on.

July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying...
Enteral Nutrition, Omega-3 (Flax Oil and Fish Oil), VSL#3, Vitamin E, Folic Acid, Psyllium

Post Edited (Illini) : 5/19/2008 5:40:36 PM (GMT-6)

Mormor Vicky
Veteran Member

Date Joined Mar 2007
Total Posts : 684
   Posted 5/19/2008 10:57 PM (GMT -6)   
From what I understand that granulomas (giant cells) are abnormal cells and is a sign of Crohn's but not everyone has them. My daughter does but I don't.
Vicky / 48 years old
DX'd with Crohn's during a resection August 2006
DX'd with Steriod induced Diabetes November 2006
Considered in Clinical remission but have minor signs of disease activity
Daughter (27) also has Crohn's since she was 12.
Currently on 4000mg of Pentasa only for Crohn's
No longer able to take 6-MP because of Bone-Marrow Suppression
Cymbalta, Metformin, Lipitor

Veteran Member

Date Joined Mar 2005
Total Posts : 2486
   Posted 5/20/2008 1:48 AM (GMT -6)   
Ugh, I saw the words "giant cell" and had to respond even though I hate giant cells...yes, the giant cells make up the granulomas, which are pretty much a sure sign of Crohn's if found in the intestine...
Co-moderator - IBS Forum

Please always remember to consult your medical professional regarding your medical questions; this forum is intended to provide patient-to-patient support. Although some of us have healthcare backgrounds, we cannot diagnose or treat patients on the board.

Regular Member

Date Joined Apr 2008
Total Posts : 30
   Posted 5/20/2008 1:59 PM (GMT -6)   
Thank you so much! I must not be a very good googler because I couldn't find anything! I'm glad to know it's not anything weird or unusual! Thanks again everyone!
30 years old~ Diagnosed in 2000 with Crohn's~ Currently taking 3000 mg Pentasa, Prednisone, and Bentyl.

Glad Bag
Veteran Member

Date Joined Mar 2007
Total Posts : 699
   Posted 5/21/2008 2:43 PM (GMT -6)   
that's a good one...."must not be a very good googler"
"I am he as you are he as you are me and we are all together!" - The Beatles

doesn't that just sound cool when you sing it?

New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, October 22, 2016 11:16 AM (GMT -6)
There are a total of 2,710,123 posts in 298,862 threads.
View Active Threads

Who's Online
This forum has 153409 registered members. Please welcome our newest member, hlpdacvws.
293 Guest(s), 11 Registered Member(s) are currently online.  Details
PeteZa, PeterDisAbelard., Luv2Travel, Huddie, Dee60, lyme2015, soynomore, caramba, gilly2, Maraki, Megan Eliz

Follow on Facebook  Follow on Twitter  Follow on Pinterest

©1996-2016 LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer