Post Edited (tsitodawg) : 11/12/2011 5:22:25 PM (GMT-7)
tsitodawg, I am currently finishing up a clinical trial for Cimzia. I started it over a year ago after stopping Remicade due to allergic reactions and lose of response. Cimzia is similar to Humira but, from what I've been told and researched, has no mouse proteins (Humira has a small amount). Cimzia helped with the stomach pain and some with the arthritis pain (I've never had D with my Crohn's, so the stomach and joint pain were my biggest complaints). But, once winter got here, the joint pain got worse and, while the Cimzia helped, it didn't help enough to keep me from having to take arthritis and pain meds also (which caused 3 ulcers and forced me to have to stop taking the arthritis meds).
So, now the trial is ending since the FDA approved Cimzia and Tuesday will be my last injections. Instead of continuing to get the drug on the market, my GI wants to try Humira to see if that will help more with the joint pain and prevent me from having to take pain meds each day. My only concern with Humira is that there is still some foreign proteins and it sounds like a lot of people have reactions to it and get rashes, itch, etc. The only problem I ever had with Cimzia was a reaction site whelp (and I got the worst reaction of anyone on my particular trial). So, I will try Humira but may have to go back to Cimzia if my body doesn't like the small amount of foreign protein.
Anyway, I'm thankful that I got on the trial and have had a much better year due to it. If you've had problems with Remicade, definitely give Cimzia a shot.
Post Edited (Illini) : 5/22/2008 12:01:21 PM (GMT-6)
So here's what I found:"Certolizumab has been constructed by grafting the short hypervariable complementarity-determining regions derived from the murine monoclonal antibody HTNF40 onto an otherwise virtually human Ig Fab′ fragment" GASTROENTEROLOGY 2005;129:807–818So I think all that's saying is that the part of Cimzia that actually recognzies TNF is mouse-based.Then looking further into Humira:"Unlike infliximab, adalimumab contains no nonhuman sequences, making it indistinguishable in structure and function from naturally occurring human IgG1." Reference: http://dermatology.cdlib.org/122/case_reports/adalimumab/hsu.htmlBut Humira was made by fusing human and mouse components together, and later separating out the "human" parts and combinging them together to make something "fully human." Did a little bit of mouse get left behind? I don't know. The same paper says that 5% of rheumatoid arthritis patients treated with Humira develop a reaction. Maybe that's where the 5% comes from? Reference: Molecular Interventions 3:310-318 (2003)Regarding how the drugs are made (now don't get freaked out!) that same paper above says: "...inserted into an appropriate mammalian cell line––Chinese hamster ovary cells in the case of adalimumab [Humira]––for production."
Wow! There's so much in this thread!
Tsitodawg--it's great to hear you've found someone who listens to you. Most people (me included) went to the first GI and thought that doctor should have all the answers on CD. Unfortunatly, most of the docs out there only have a couple of CD patients and don't really know the basics. That is why it is so important DO NOT BE AFRIAD to shop around for a doctor.
As for the mouse versus human component, I was hung up on that for awhile, too. But I went to an educational program and asked the doctor about this. The answer went something like this, "anything we put in our bodies is foreign to our body. Even if I have a kidney transplant (which is human) my body would try to resist. Therefore, it doesn't matter if there is a mouse component."
I also asked about the pegylation and it was said that it makes the drug stay in the body longer and I think he said it made it safer.