TGN test variability

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New Member

Date Joined May 2008
Total Posts : 19
   Posted 5/25/2008 1:35 AM (GMT -6)   
Hi all,
I'm new here but I have had Crohn's for a while. I was wondering if others monitored their 6-TGN levels while on 6MP or azathioprine? I understand the test indicates how effective the drug is but I have noticed my levels jump around while I am on a constant dose of 6MP. When I mean jump around, I mean like moving from 150 to 400 while on a constant daily dose of 25mg (I think the theraputic range is 250-450). Any thoughts as to why the results move would be great.
26F, Crohns 8 years, pentasa, 6MP.

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 5/25/2008 1:39 AM (GMT -6)   
Wow, I've been on azathioprine and haven't heard of the TGN test. I just tried Googling it and it sounds pretty specialised.

Did you notice any difference with how you were feeling, when your TGN was at different levels?

Welcome to the forums!

Ivy, in Australia (are you?)
Co-Moderator Crohn's Forum.

New Member

Date Joined May 2008
Total Posts : 19
   Posted 5/25/2008 3:12 AM (GMT -6)   

Thanks for the reply Ivy, I'm a New Zealander.

The 6-TGN test stands for 6-thioguanine nucleotides. Here is a link to a NZ article on the topic

I think it is mainly used when people start on azathioprine or 6MP to adjust doses, but I have had blood tests for this for a few years now and I can't work out why the results vary.  


26F, Crohn's for 8 years, currently on 6MP and pentasa. Have previously tried remicade and iron.

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