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crohns7
New Member


Date Joined Apr 2008
Total Posts : 5
   Posted 6/16/2008 5:16 PM (GMT -7)   
Where can i find an explanation of each test done in the serology 7 test.  Not all of my tests came back abnormal but I was wondering what they meant.

Illini
Regular Member


Date Joined Dec 2007
Total Posts : 298
   Posted 6/16/2008 7:56 PM (GMT -7)   
There is not a good place to get this info...basically have to go to the medical journals. But here is a summary for the ones I understand:

ASCA IgG/IgA: antiSaccharomyces cerevisiae antibodies. Both of these are antibodies against Saccharomyces cerevisiae, which is baker's yeast. More specific to Crohn's.

pANCA: Perinuclear antineutrophil cytoplasmic antibodies. These are antibodies against the inside components of human neutrophil cells. This is an auto-antibody. More specific to UC.

anti-OmpC: Antibodies against an Outer membrane protein that is on the surface of bacteria. Associated with perforating/fistulizing Crohn's.

anti-Cbir1: Antibodies against bacterial flagella. Flagella are hair-like structures on bacteria that allow them to "swim." Associated with perforating/fistulizing small bowel Crohn's.


July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying...
Enteral Nutrition, Omega-3 (Flax Oil and Fish Oil), VSL#3, Vitamin E

Post Edited (Illini) : 6/16/2008 11:29:01 PM (GMT-6)


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 6/16/2008 9:36 PM (GMT -7)   
The Serolgy 7 tests for the following with the values:
ASCA IgA ELISA: <20.0 EU/mL
ASCA IgG ELISA: <40.0 EU/mL
{These two phenotypes are present in Small-bowel disease, fibrostenosis, internal perforating disease, small-bowel surgery]
anti-OmpCb IgA ELISA: <16.5 EU/mL [Phenotype present in Fibrostenosis, internal perforating disease, small-bowel surgery]
anti-CBir1a ELISA: <21.0 EU/mL [Phenotype present in Small-bowel disease, fibrostenosis, internal perforating disease]
AutoAntibody ELISA: <12.1 EU/mL [Specific in UC-like CD]
IFA Perinuclear Pattern: Not Detected
DNAse Sensitivityb: Not Detected [used to strengthen a diagnosis before J-pouch surgery]
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, Sjogren's ?
 


crohns7
New Member


Date Joined Apr 2008
Total Posts : 5
   Posted 6/17/2008 4:27 AM (GMT -7)   
My NSNA DNASE was sensitive  and the NSNA IFA Perinuc was detected, can someone explain to me what they mean?
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