Post Edited (Crohn's 4 ever) : 6/21/2008 4:00:54 PM (GMT-6)
5-ASA is poorly-absorbed by the intestines, and hence provides topical relief within the intestine. It is therefore a non-systemic drug. 5-ASA is related to the systemic non-steroidal anti-inflammatory drugs (NSAIDs), such as Aspirin and Ibuprofin.
The free radical induction theory, discussed above, proposes that 5-ASA is serving not just as an anti-inflammatory, but also as a free radical trap, destroying the hydroxyl and other radicals that may damage colonic epithelial barrier.
Post Edited (pb4) : 6/22/2008 7:50:53 PM (GMT-6)
Post Edited (Jen77) : 6/23/2008 9:30:30 AM (GMT-6)