How long until Humira kicks in?

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Regular Member

Date Joined Oct 2007
Total Posts : 76
   Posted 6/24/2008 2:00 PM (GMT -6)   
Hello!  After a few years on Remicade, many bouts of serum sickness, and reactions during each and every infusion, I'm finally on Humira.  I had my first dose of 4 shots last Friday, and I'm due for my second round, of 2 shots, this Friday.  My question is, how long did it take for those on Humira to start seeing an improvement in their symptoms?  I used to start feeling better about a week after my Remicade infusions, but it lost it's effect on me about 10 months ago, and I've been extremely ill since, I've lost 74 pounds in the last 8 months.  I am anxious for the Humira to start doing it's job, hopefully as well as Remicade *used to*, so I can finally have some relief and not spend my life either in the bathroom or curled up in a ball in pain.  Thanks!!!
Asthma (diagnosed at 12)
Fibromyalgia (diagnosed 9/01)
Crohn's Disease/Colitis (diagnosed 12/02)
Diverticulitis (diagnosed 6/07)
Chronic pelvic pain/endometriosis, leading to hysterectomy (9/07)
Torn rotator cuff/labrum (repair 11/20/07)
Bladder sling (8/06), cholystectomy (2/06), tubal ligation (2/06), failed ablation (3/07)
Just found out I'm allergic to wheat and eggs too! @@
Taking Asacol, Prednisone, Entocort, Remicade, Levbid, NuLev, HCTZ, Lisinopril, Cymbalta, Elavil, Prevacid, Zantac, Lomotil, Soma, Bentyl, Ambien, Frova, Doxycycline, Questran powder/Carafate suspension, pain meds and LOTS OF VITAMINS AND SUPPLEMENTS!

Forum Moderator

Date Joined Nov 2003
Total Posts : 7055
   Posted 6/24/2008 3:42 PM (GMT -6)   
Not to be discouraging, I never got the relief from Humira that I got in the beginning with Remicade. I too did well on Remicade for over 2 years. Then the next six months were reactions that caused me to feel worse after Remicade than before the infusion. So I was switched to Humira.

I lasted 3.5 months on Humira before I had the mother of all reactions. My GI told me that there is a quite large percentage of people that if they reacted negatively to Remicade or that it lost its effectiveness over time - these people will find Humira ineffective or they will react to it also. My rheumy also said that people that developed Remicade induced lupus symptoms run a higher risk of the same thing happening with Humira. That is what happened to me.

Now I hope the next gazillion people that post have nothing but positive things to say about switching! Good luck and I hope the Humira kicks in quickly!
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.

Crohn's 4 ever
Regular Member

Date Joined May 2008
Total Posts : 207
   Posted 6/24/2008 6:48 PM (GMT -6)   
Hi, I will have been on it 3 months this Friday, however I have had a good two weeks with it in the second month, absolutely no pain, nothing then the next shot...I was under tremedous stress and the shot didnt help at all.  Was in pain and went to the docs, got Prednisone just in case, month I am on prednisone. 40mg.  I am not discouraging you ,but you have to give it 3 to 4 months, some others have said it takes a full 4 months, so I am praying, I picked Humira because I was highly allergic to Remicade, went off and waited almost a year and now Humira.  Hang in there, dont stress over it, because that will stop it from working.  Good luck let us know your progress.

Tough times don't last long, tough people do!

Regular Member

Date Joined Jan 2006
Total Posts : 355
   Posted 6/24/2008 9:02 PM (GMT -6)   
I thought Remicade was so fabulous because I noticed nearly immediate results. Two days later after the first infusion I saw improvements. Then by 10 days later I was back to my normal problems. After a while the good results lasted only about a day or so. Then I did develop the bad reactions to it. about two years later I went on Humira without much hope as I had tried everythig under the sun known to possibly work. After about three months, I went into my first ever remission. I remain so still after two years. I hope you have the same good response that I did. But certainly you will have to give it time. It does not seem to work as quickly as Remicade, but for me it seemed to build up and now works better than I ever imagined possible.

Regular Member

Date Joined Mar 2006
Total Posts : 111
   Posted 6/24/2008 9:18 PM (GMT -6)   
I started Humira shots on Feb. 4, 2008 and I had somewhat formed stool beginning on March 15, 2008. I have never had abdominal pain so I can't speak for that.
34 years old
Diagnosed with CD 1993
Currently taking Asacol, 100mg Immuran, 7.5mg prednisone (tapering), Humira injections twice monthly since Feb 08, Fish Oil, Probiotics, Multi Vitamin, B-12 tablet, folic acid

Regular Member

Date Joined Nov 2008
Total Posts : 351
   Posted 10/10/2009 5:32 PM (GMT -6)   
Can anyone else reply to this question? They are planning to start me on it and I want to know how fast it can put me in remission.
27m - Dx January 2005: UC/Crohn's
Entocort 9 mg, Asacol 4 x 3, Flagyl 500mg x 3

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 10/10/2009 5:38 PM (GMT -6)   
I would say it was probably a month or so before I noticed any improvement on Humira.  This was after switching from Cimzia (when it was in the clinical trial phase).  Humira only helped for 6 months or so before starting to lose effectiveness (mainly with the arthritis, not the other Crohn's symptoms).  I stayed on it for about 14 months and just couldn't deal with the arthritis flare any longer, so I switched back to Cimzia about 3 weeks ago.  I noticed it helping 5 days after the first shots.  So, Humira did seem to take longer than the Remicade and the Cimzia to work for me. 
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 10/10/2009 5:41 PM (GMT -6)   
Give it at least 4 months. That's about how long it took for me.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.

Go Saskatchewan Roughriders!

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