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medchrt1
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Date Joined Sep 2005
Total Posts : 517
   Posted 7/1/2008 11:37 PM (GMT -6)   

the mention of granuloma (on another post) got me browsing internet and to reading an article on a lady diagnosed with  Malakoplakia an uncommon chronic granulomatous inflammatory disease, not unlike crohns I suppose …anyways …they changed her medicinal regimen from mercaptopurine (was stopped) and “the subsequent management was based on the reliable intracellular penetration of quinolones antibiotics into the macrophages and the hypothetic capability of ascorbic acid of improving the macrophage function by increasing the cyclic guanosine monophosphate”. That’s a mouthful, but noteworthy. I guess I dont hear enough from gastro docs of (natural rememdy) improvement from vitamin C especially for this cycle: Cyclic guanosine monophosphate (cGMP) which deals with regulator of ion channel conductance. It gives me a relationship between granuloma and treatment, albeit not for crohns per se, but the electrolytical approach/correction would seem to me important enough to be mentioned by a doctor for crohns.

I suppose we could answer if vitamin C was beneficial to ourselves, but they should investigate this cgmp thoroughly from the standpoint of ion correction for us, and not just result in drugs for cgmp inhibition.

http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijge/vol5n2/crohn.xml

http://ezinearticles.com/?Vitamins-and-Crohns----How-to-Select-the-Right-Supplements&id=504592


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14994
   Posted 7/2/2008 10:52 AM (GMT -6)   
I hate to tell you, but I did not make any sense out of what you just wrote. It was like Greek to me. (Sorry Athens) Maybe if you wrote this in more layman's terms you might have better understanding of the point you are trying to make.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 7/2/2008 3:28 PM (GMT -6)   
I didn't get it either, but, vitamin C in large doses is a natural laxative-I would want to avoid that.
Sj

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18011
   Posted 7/2/2008 3:36 PM (GMT -6)   
I've heard a similar theory which is why I started taking Vitamin C-Calcium Ascorbate which is easy on the gut, it has not caused me any extra issues and along with all the other naturals that I take it likely helps with things.

I take bee propolis, fibre supplements, probiotics, omegas 3-6-9, Vitamin C-Calcium Ascorbate, vitamin A and B12, drink chamomile tea everyday as well and eat extra virgine olive oil everyday too.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Illy
Regular Member


Date Joined May 2008
Total Posts : 117
   Posted 7/3/2008 8:18 PM (GMT -6)   

I don't know anything about vitamin C and cgmp, but I have read that vitamin C increases the numbers and efficiency of macrophages.

But what exactly was your point?  I was also puzzled.


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18011
   Posted 7/3/2008 9:18 PM (GMT -6)   
Too much vitamin C can cause issues...although high doses of Vitamin C can protect against cellular damage, 500 mg per day resulted in the increase of oxidative species, 8-oxoadenine and 8-oxoguanine, in an individual’s blood lymphocytes, causing damage to the white blood cells. White blood cells protect against infection in the body. The study suggests while cellular protection is sufficient with 100-200 mg of Vitamin C daily, amounts of 500 mg prove harmful to the body. I was worried because once when I was little I ate a whole bottle of orange flavored vitamin C so I thought that maybe I brought the CD on myself by doing this but I also know that one has to be predisposed to getting IBD in the first place and with my mom having UC that is my connection to getting crohn's (genetics).

I didn't get sick with CD until my early 20's well after eating all those vit C tabs.

:)


My bum is broken....there's a big crack down the middle of it!  LOL  :)

Post Edited (pb4) : 7/3/2008 8:22:16 PM (GMT-6)


Illy
Regular Member


Date Joined May 2008
Total Posts : 117
   Posted 7/3/2008 9:37 PM (GMT -6)   
pb4 said...
 The study suggests while cellular protection is sufficient with 100-200 mg of Vitamin C daily, amounts of 500 mg prove harmful to the body.
 
which study?
 

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18011
   Posted 7/3/2008 9:41 PM (GMT -6)   
I don't know, I've lost the link to it...some study somewhere I guess LOL!
My bum is broken....there's a big crack down the middle of it!  LOL  :)


medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 7/4/2008 6:21 AM (GMT -6)   
dont mix vitamin C with iron
 
 
what as my point,,,well i was looking at the possible benefits of vitamin C...as far as my goal was..i was looking for a correction to bowel membrane (voltage) from a electrical standpoint, (because we generally leak potassium) and looked at vitamin C, however it has both abilities anti-oxidant and pro-oxidant, so my search continues.

medchrt1
Veteran Member


Date Joined Sep 2005
Total Posts : 517
   Posted 7/4/2008 6:44 AM (GMT -6)   

sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 7/4/2008 9:07 AM (GMT -6)   
Okay that article about Iron and Vitamin C is interesting. My doc recommended Vitron C an Iron and C combination product when I was anemic and I am still taking it I havent noticed any problems but I think I am now switching to gentle iron.
Sj
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