I took MTX for many months for Connective Tissue inflammation (Lupus?). I was taking 15 mg once a week and then increased it to 20.
I was instructed to make sure and take folic acid every day (can't remember the amount, but it was more than 1 pill). I was really scared of the MTX and cleaned my bathroom really well before my first dose. Ha haaaa
No nausea at all. I was a bit sleepy the day or two after my weekly dose and I made sure to take it just before bed so I would sleep through anything weird.
Lots of folks at the Lupus and Chron's forum use MTX and it seems to help a lot. I found that my fatigue lifted with the MTX too. It does take several weeks to really kick in though.
You can choose which day of the week you take it . . . I chose a Friday evening so by Monday I was back to "normal".
Hope this helps!!
In His Grip
AlwaysRosie "We can't control the waves, but we can learn how to surf!!"
Co-Moderator - Lupus Forum
UCTD, Inflammatory Arthritis, Diverticulosis, (recent dx - Sjogrens, Crohn’s 4/08)
Clickable Links: Lupus Resources Lupous.Org Lupus Criteria (4 of 11) Lupus Chapter Locator