Remicade antibodies and Humira

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magnetic
Regular Member


Date Joined Apr 2006
Total Posts : 84
   Posted 7/24/2008 6:20 PM (GMT -7)   
Hi,
I was on Remicade for a year or so and developed antibodies in January 2008
I had another DNA test done for the presence of the antibodies and they are still there but reduced.
 
Does anyone know if I can be started on the Humira when I still have the antibodies to the Remacide?
 
Thanks,
  M 
Diagnosed June 2005 with Crohns (left colon, large bowel)
Diagnosed Osteopenia Feb 2006
Jan07 Arthritis noticed in hands, not too bad yet
Remacide started March 2007, Developed anti-bodies Jan 2008, Remacide stopped Jan 08
Crohns Arthritis Diagnosed January 2008, not getting any better yet
 
Asthma since childhood
 
changed my style to silver
changed my clothes to black


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 7/24/2008 7:36 PM (GMT -7)   
I assume when you say you had another DNA test, you mean that the antibodies you developed were anti-dsDNA antibodies. Those are the antibodies found in people with lupus. If those are NOT the antibodies you have, then read no further.

I was started on Humira and still had anti-dsDNA antibodies from Remicade. In hindsight, I am not sure it was that good of an idea. There is no way to tell if my current problems stem from the Remicade or the Humira. I had a severe reaction after 2.5 months on Humira. It is thought my reaction was caused by the anti-dsDNA antibodies. I stopped Humira 7 months ago and I still have the antibodies. That along with swollen, inflamed joints, a fever of 3 months, protein in the urine, severely depressed C3 complement, and major fatigue led to a diagnosis of lupus. So now I have lupus outright. Did the Remicade and/or Humira cause the lupus? Possibly according to the doctors. However, they said I might have had the underlying disease and the meds brought it out.

I think you need to have a serious discussion with your doctor about this. Is it the GI or rheumatologist that wants you to start Humira now? He/she really needs to evaluate you for other symptoms because you still have the anti-dsDNA antiobodies. All the literature says they go away in 4-6 months after stopping Remicade. You are past that time frame.

How are you feeling otherwise? Please don't let what I have written frighten you away from Humira. Just make sure you have a talk with your doctor about it.


Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 

Post Edited (Ides) : 7/24/2008 9:54:34 PM (GMT-6)


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 7/24/2008 8:36 PM (GMT -7)   
We're so lucky to have you, Ides. You really know your stuff.
Co-Moderator Crohn's Forum.


magnetic
Regular Member


Date Joined Apr 2006
Total Posts : 84
   Posted 7/24/2008 11:18 PM (GMT -7)   

Ides,

From the information I have, the antibodies are the Anti-dsDNA ones.
My rheumatologist talked to the GI, and then advised me of the antibodies still been present.
He advised I could not go on the Humira at the moment

I'm currently on Methotrexate, folic acid, Pentasa, Entocort steroids, calcium tablets, fosamax and Solpadol painkillers.
I'm also on tablets for Gastritis.
The rheumatologist has also stated (every time I've seen him) that I have Lupus type symptoms
My crohns is not great, but it looks like the Methotrexate may be kicking in now?
I also get RSL (Restless Leg - thats what I call it, but the doc's don't seem to pay it any mind), which usually occurs at bedtime, preventing me from sleeping.
I have lots of tiredness on top of all this, since the crohns first started 4 years ago
I was diagnosed with Crohns related arthritis, which gets worse by driving 30miles to work and another back home.
I was taking painkillers to get into and out of work, and then during the day and at night.

I'm currently on medical leave from work, about 6 weeks so far. They'll stop paying me in another 4 weeks or so.
I'm anxious to get back to work, but I know that I'll be back on the 4 lots of painkillers with the driving, unless the arthritis stops.
Thats why I was hoping I could go on the Humira.

I looked on-line but was unable to locate information on the antibodies and how long it takes to get them out of your system.

Rgds,
 M


Diagnosed June 2005 with Crohns (left colon, large bowel)
Diagnosed Osteopenia Feb 2006
Jan07 Arthritis noticed in hands, not too bad yet
Remacide started March 2007, Developed anti-bodies Jan 2008, Remacide stopped Jan 08
Crohns Arthritis Diagnosed January 2008, not getting any better yet
 
Asthma since childhood
 
changed my style to silver
changed my clothes to black


chroniemomx2
Veteran Member


Date Joined Apr 2005
Total Posts : 2346
   Posted 7/25/2008 5:19 AM (GMT -7)   
Would pred help reduce the antibodies faster?

Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 7/25/2008 9:49 PM (GMT -7)   
Magnetic,
I want to write more to you but am crunched for time tonight. I will come back tomorrow and write more in detail.
Ides
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 7/26/2008 3:27 PM (GMT -7)   
As I wrote before, all the literature states that the anti-dsDNA antibodies should clear in 4-6 months after the cessation of Remicade. The majority of studies found the antibodies cleared in 4 months. There were some cases that took 6.

If your rheumatologist advised you not to go on Humira, I would highly recommend you taking his advice. I went on Humira while the antibodies were still present. I got VERY ill.

It is very possible that your arthritis symptoms and fatigue are related to the LUPUS, not the CD. Have they tried you on a short course of prednisone to see if that brings you any relief? I had a fever, inflamed and swollen joints, and horrid fatigue for 3 months. When I went on a 12 day taper [30>5 mg] of prednisone, I felt like my old self. Those symptoms plus weird rashes and increased hair loss plus the presence of the antibodies has led my rheumatologist to diagnose me with Lupus outright.

Chroniemomnx2 - prednisone will not help decrease the antibodies. However it will help with symptoms that the antibodies' presence create.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 7/26/2008 3:48 PM (GMT -7)   
The mtx may end up helping the arthritis as well. Then the need for pain relievers may be reduced. Pred would also help with the arthritis. You may need specific meds for the RLS so that you can sleep better which may help your other symptoms.
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