Why Remicade first then Humira? Remicade VS Humira

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redspot321
Regular Member


Date Joined Jan 2006
Total Posts : 303
   Posted 7/27/2008 5:56 PM (GMT -7)   
When researching the TNF blockers many sites say to use Humira AFTER Remicade has stopped working.
 
My GI wants to try me on Humira first. For those of you who have used both of these drugs which one worked better?
29 YO Male
 
-CD diagnosed in 2005 illieum
-63cm bowel resection in Feb 08
-Steroid dependant following surgery
- LDN Naltrexone started May 08 been a happy man since!!


potatoqwn
Regular Member


Date Joined Jan 2006
Total Posts : 355
   Posted 7/27/2008 6:56 PM (GMT -7)   
Humira worked better for me hands down. Remicade worked a little bit. But Humira put me into remission.

redspot321
Regular Member


Date Joined Jan 2006
Total Posts : 303
   Posted 7/27/2008 8:44 PM (GMT -7)   
Are there any differences in side effects between the two drugs?
29 YO Male
 
-CD diagnosed in 2005 illieum
-63cm bowel resection in Feb 08
-Steroid dependant following surgery
- LDN Naltrexone started May 08 been a happy man since!!


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 7/27/2008 8:52 PM (GMT -7)   
Side effects for both drugs are very similiar with one exception. Some people complain of painful injection site reactions from the Humira. I am curious about who is recommending Remicade before Humira. Remicade was approved for CD sometime before Humira was so many people took Remicade first because it was available. I have seen no studies showing that Remicade should be tried before Humira. The one exception is in fistulizing Crohn's - I believe that Remicade has been shown to be superior in closing fistulae.

The decision to take Remicade or Humira first should be made in consultation with your doctor. You might want to see which is more affordable for you because insurance plans cover the two meds differently. Both mahufacturers have assistance programs for people that have trouble paying.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


redspot321
Regular Member


Date Joined Jan 2006
Total Posts : 303
   Posted 7/27/2008 8:55 PM (GMT -7)   
"Overall, the study shows that Humira is a strong option for Crohn's disease patients -- when Remicade no longer works, writes Papadakis."
http://www.webmd.com/ibd-crohns-disease/news/20050201/humira-relieves-crohns-disease-symptoms

Ive just read many articles like the one above. I didnt know if one was more dangerous than the other.
29 YO Male
 
-CD diagnosed in 2005 illieum
-63cm bowel resection in Feb 08
-Steroid dependant following surgery
- LDN Naltrexone started May 08 been a happy man since!!


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 7/27/2008 9:26 PM (GMT -7)   
This study was part of the testing of Humira prior to its approval for use in CD. At that time, Remicade was the only biologic approved for usage. They were testing to see if people responded to Humira after they had been on Remicade because at that time, it was not known if the Remicade usage might change the way people responded to Humira.

Papaakis is saying that Humira is another drug choice when Remicade no longer works. Studies were also done on CD patients that had never had Remicade to test Humira's effectiveness. I believe these trials were called Classic II.

Go to Remicade's home page and read the Improtant Safety Information. Then do the same at Humira's site. You'll see the extensive list of precautions. They are quite similar.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 

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