I thought we weren't supposed to take methotrexate in combination with mesalamine? The mesalamine boosts the levels of methotrexate, and can lead to toxicity.
I'm considering going on mtx (really don't want to do it). A friend with RA has been on it, and she said that she had to drink A LOT of water while she was on it, or she'd have side effects. If she peed less than once an hour, she's start having problems.
I am going through something similar right now. I have been on MTX for about 3.5 months, and the last blood test showed elevated liver function tests. I went down to 15 mg and redid my blood tests in 2 weeks. They just called today and they were still elevated. I have to go down to 12.5 mg and go for blood tests in 2 weeks. Prior to this, my blood tests have been fine.
I was feeling pretty good on MTX, but the last week I've had an unsettled stomach. I also stopped recently stopped taking Xifaxan and switched to MTX pills, so I'm not sure what is causing it. I'm also going on vacation starting Friday, so it could be just nerves as well.
I hope you get this resolved quickly.