I am new here, but lurk and read daily. Your post caught my attention and I wanted to come out from behind the curtain to respond!
I have taken Lotronex for over six months and have had no side effects whatsoever. It does help out in addition to the Lialda that I take and occaisional rounds of entocort when things have gotten bad enough. I take it twice daily and it has certainly cut down on the number of trips to the bathroom I make each day and I am not a hostage in my home anymore. For me, it is a good thing. I follow the instructions given to me by my GI, but I have never had any danger signs to report.
I should add that I do not have Crohn's, but a type of microscopic colitis called Lymphocytic Colitis. In three years since diagnosis, I have not ever been in complete remission, but I feel bad complaining about that here, seeing what you guys go through.