Severe anemia / Wellbutrin Chrons

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ubob
Regular Member


Date Joined Dec 2003
Total Posts : 98
   Posted 8/7/2008 8:48 PM (GMT -7)   
My daughter has maintained remission for the past 5 years by taking wellbutrin, she has recently developed severe iron deficeny anemia and I am wondering if this could be as a result of the antibiotics she is taking Cipro and Flagyl. Has anyone else had this problem with these meds???.

Ubob

jacenta
Regular Member


Date Joined Nov 2006
Total Posts : 47
   Posted 8/7/2008 9:16 PM (GMT -7)   
from what i read wellbutrin is an antidepressant drug!http://www.drugs.com/wellbutrin.html when i developed iron defficiency my doctor told me that i must be bleeding from somewhere. after all the tests colonoscopy endoscopy and capsule endoscopy found that i had crohn's in the small bowel. the doctor said that thats from where i was bleeding even though i couldnt see the blood thus my anemia. from what i know antibiotics can reduce your white cell count and platelets. it happened to me.

good luck

Keeper
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Date Joined Jun 2008
Total Posts : 1058
   Posted 8/7/2008 9:38 PM (GMT -7)   
When taking antibiotics, there are a couple of particularly resistant bacteria that remain in the gut. There are reports of Bacteroides Fragilis showing resistance to both the antibiotics you mention and there are also some unrelated reports that it can steal iron from your body. Iron is a growth-limiting factor for most bacteria and this one seems to have developed a trick for siphoning iron from the system. I don't know if this is enough of a factor that it might produce anemia, but possibly in connection with impaired absorption and possible bleeding it could be a contributor. Oddly enough, this bacteria which is so drug resistant can be flushed from the system in about a week by using whey. It seems that the whey will support the growth of friendly bacteria which out-compete the resistant one. Of course, after antibiotics, you would have to reintroduce the friendly bacteria for that to work. See: http://jds.fass.org/cgi/content/abstract/81/5/1229

CrazyHarry
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Date Joined Mar 2006
Total Posts : 1034
   Posted 8/8/2008 7:32 PM (GMT -7)   
i am dealing with severe iron deficiency now, but i havent been on either of those antibiotics in years. my anemia started this time last year, totally out of the blue too. i had to get 2 units of blood in july and september of last year. i've been on iron supplements ever since. my blood work looks good, but my iron stores are very low (teens to low 30s - should be at least 50). i thought that being on iron pills for like 4 months was good enough to kick start my system and things would get back to normal on their own, so i went off iron for a couple of months and everything tanked. docs dont know what is up and just want to monitor my blood (thanks for nothing). i suspected it was the 6-mp as i was on it for like 12 years and it causes bone marrow suppression. i stopped it but things havent really turned around for me in regards to iron levels. my next test for the iron stores is in september. hopefully things are improving....

take an iron supplement, eat more leafy greens, and eat steak cooked medium rare at most. also liver is good too for anemia.
Crazy Harry

---------------------------------------------
Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 8/8/2008 10:17 PM (GMT -7)   
CrazyHarry - there are two possible causes that the docs may have overlooked. The first is Celiac disease. That causes general malabsorption of nutrients and iron is included. That is less likely for you because iron supplements seem to work. The second is a B12 deficiency to the extent of pernicious anemia. That is unlikely also unless you have been a vegetarian for a few years. Finally, since the iron is absorbed in the small intestine, a food allergy may impair the function of that area. After all that, your idea of 6-mp causing the problem is a pretty good bet.

Osprey101
Regular Member


Date Joined Apr 2008
Total Posts : 227
   Posted 8/8/2008 10:43 PM (GMT -7)   
Iron deficiency in Crohn's patients may be tied to infection with MAP, an organism that has been closely associated with the disease for years but never directly implicated.

From "Biology of the Mycobacteria" by Ratledge and Stanford (1983):

"The pathogenic mycobacteria are among those organisms for which there is compelling evidence that the availability of iron as a microbiological nutrient plays a critical role in infection.Further, A normal host response to infection is a depletion of iron availability with an increase in the amount of unsaturated serum transferrin, which can render the serum bacteriostatic.This property includes extracellular as well as intracellular growth of mycobacteria."

In other words, the body hides iron from the organism, trying to slow down its growth. The answer is to supplement, and for those of us on the Specific Carbohydrate Diet, adding more iron is like getting stuck in the stomach with a hatpin. Added iron may benefit the growth of the organism.

CrazyHarry
Veteran Member


Date Joined Mar 2006
Total Posts : 1034
   Posted 8/9/2008 8:21 AM (GMT -7)   
keeper -

i dont think i have celiac. i do eat gluten free as much as possible and in fact dont eat a lot of grain based foods and stay away from processed foods and refined sugars. i've become super anal about that since 2007. i did have 2 inches at the ileum removed, so your b-12 theory holds some truth there. i have been taking b-12 supplements about the time i started my iron. this occurred to me too and i had my docs screen for b-12 and that was low as well. it was just odd how it started all of a sudden and out of the blue. i did respond well to the iron supplements, which was good. i could not get my iron levels up eating a diet high in iron based foods though. that leads me to believe that i was so low it would take way too long or there is some underlying cause i havent discovered yet.

as for being a vegetarian, i love meat too much. imho vegetarianism isnt healthy. actually, the word vegetarian comes from ancient tribal slang for the village idiot who cant hunt, ride, or fish.



osprey101 -

i loosely follow the scd, incorporating parts of it with the maker's diet. that is why i did the food based iron method first. but i had no choice and had to go the pill route.


thanks for the comments every one!
Crazy Harry

---------------------------------------------
Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 8/9/2008 8:54 AM (GMT -7)   
Aren't B-12 anemia and iron anemia different things?
Dx'ed in 1999. No surgeries.

Current meds: 75 mg 6MP. 10mg prednisone (trying to taper). Udo's Choice Probiotics (30 billion).


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 8/9/2008 11:27 PM (GMT -7)   
Yes, pernicious anemia is a chronic B12 deficiency that results in the loss of the ability to absorb B12 normally. It is also implicated in the loss of normal absorption of iron. There is also a limited ability to absorb iron in the presence of zinc and copper. If you are, by chance, taking a regular zinc or copper supplement, you might be exhausting the capacity for absorbing iron.
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