Rectal Medication

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LondonRed
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Date Joined Oct 2007
Total Posts : 790
   Posted 8/30/2008 2:34 AM (GMT -6)   
I am considering going on rectal meds but not steroid ones.
 
Is there a 5-ASA version? I don't like taking oral meds and would much rather have a suppository once a night. My bleeding is from piles but it might be (small chance) coming from the rectum - so I have these questions.
 
1. Are there any rectal meds that can treat both the inflammation and the piles at the same time?
 
2. Can the rectal meds treat the whole colon or just the rectum? (I have some small inflammation on the right side)
 
3. Does anyone here take rectal meds?
 
Please advise.

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


Julie1014
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Date Joined Oct 2005
Total Posts : 1245
   Posted 8/30/2008 4:25 AM (GMT -6)   
Yes, there are 5-ASA versions. The first one is Rowasa. It is a retention enema. The second is Canasa. It is a suppository. Unfortunately, I don't know their mechanism of action, or if they will help you. Maybe you could Google them for more info. I hope this helps! Blessings, Julie
Diagnosed with Crohn's March 2006
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 11mg/day, Imuran 50mg, Miralax as needed, Prevacid 30mg, Vit B12
Paxil 40mg daily (for Panic disorder)
Xanax .5mg as needed (for anxiety attacks)
 
 
 
 
 


LondonRed
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Date Joined Oct 2007
Total Posts : 790
   Posted 8/30/2008 8:24 AM (GMT -6)   
Is it true that rectal steroids have no side effects? and they can treat both piles and inflammation?

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14994
   Posted 8/30/2008 10:36 AM (GMT -6)   
London I would talk to your doctor about this. You seem to be a really worried over this. I don't think your doc would want to give you rectal meds if you just have hemi's. At least I think you would need to go thru another c-scope or a sigmoidoscopy to see if you had Crohns in your rectum.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


LondonRed
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Date Joined Oct 2007
Total Posts : 790
   Posted 8/30/2008 11:49 AM (GMT -6)   
I just had a colonoscopy a month ago but I feel I need a sigmoidoscopy (without the bowel prep) to see whether it is my piles or colon bleeding the bright red blood. Thanks Nanners.

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 8/30/2008 11:50 AM (GMT -6)   
London, I agree with Nanners that you should talk to your doctor. I use steroid suppositories, and have not experienced any side effects. I use Hydrocortisone suppositories 25mg at night, and Proctozone cream as needed. Both are prescription. I use them for hemmorhoids and rectal inflammation. I hope this helps.
Diagnosed with Crohn's March 2006
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 11mg/day, Imuran 50mg, Miralax as needed, Prevacid 30mg, Vit B12
Paxil 40mg daily (for Panic disorder)
Xanax .5mg as needed (for anxiety attacks)
 
 
 
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 17918
   Posted 8/30/2008 11:57 AM (GMT -6)   
LondonRed said...
Is it true that rectal steroids have no side effects? and they can treat both piles and inflammation?

Correct, the reason being is that not near the amount of steroids gets into the blood stream when administered rectally compared to orally...I've been on cortifoam for as long as a yr before tappering off and never had a single side effect...infact I've done this many times over my 17 yrs of IBD.
 
And yes, they can help treat inflammation and piles.
 
Personally I did not find salofalk suppositories effective AT ALL in my experiance, of course some have luck I'm sure, alot depends on how one's body reacts to meds and how severe the disease activity is as well.
 
You really should look into a good probiotic as well if you're not already taking one daily (and indefinitely, remission or not).
 
Rectal meds are just that, they will treat the rectom, not the colon.
 
:)
My bum is broken....there's a big crack down the middle of it! LOL :)


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 8/30/2008 11:59 AM (GMT -6)   
I used to take the CortEnemas nightly for a very long time. They are a retention enema, 100 mg hydrocortisone. I did notice slight effects of the steroids such as a bit of a the moon face... Nothing at all like when I am on oral steroids.

More recently, I have used compounded budesonide suppositories -- same steroids as Entocort. It's a quickly metobolized steroid, so it has fewer negative effects to start with. Then when I use them rectally, I notice nothing systemically (no mood face or sleep issues) but they help a lot!! They are not a typically prescribed rectal med, but my doc has customized the med and the compounding pharmacy creates them.

The enemas have the ability to travel into the left side of the colon, the suppositories really only reach the rectal region.
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 790
   Posted 8/30/2008 12:05 PM (GMT -6)   
I have rectal inflammation but that only shows on colonoscopy after a bowel prep and not on sigmoidoscopy - for some reason the bowel prep irritates my colon. But I have bright red bleeding so the it's either the rectum or the anus which is bleeding - piles or colitis. For that reason surely a rectal steroid can do the trick?

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 790
   Posted 8/30/2008 4:36 PM (GMT -6)   
I am getting just blood sometimes without much stool, or some blood before the stool comes out. Is it possible for piles to bleed or pool up blood on their own? Or for me to bleed when I pass a lot of wind? Surely this is inflammation and NOT piles for certain?
 
I often feel like going to the toilet, have the urge, but then nothing comes out except for some blood on the tissue!


Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)

Post Edited (LondonRed) : 8/30/2008 3:54:34 PM (GMT-6)


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 8/30/2008 5:53 PM (GMT -6)   
London, you have some very good questions and have received good answers. However, it might be best to see your doctor. They could do a quick rectal exam to see if the bleeding is caused by hemmorhoids. Hemmorhoids can bleed on their own. Also, a fissure can bleed. (rectal tear.)


Diagnosed with Crohn's March 2006
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 11mg/day, Imuran 50mg, Miralax as needed, Prevacid 30mg, Vit B12
Paxil 40mg daily (for Panic disorder)
Xanax .5mg as needed (for anxiety attacks)
 
 
 
 
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 790
   Posted 8/31/2008 4:42 AM (GMT -6)   
Thanks Julie. I am updating my GI by email about all this until I meet him in 3 weeks time. He is h appy to go with rectal meds and remained convinced it is my piles. I took some fibre supplememts yesterday and last night and today I don't have much blood but bulkier/softer stool. I did notice some blood on the outside of the stools but none on the tissue and no dripping blood. Which is good news.

I guess with us having D and other bowel problems it's inevitible many of us have hemmies - with blood being a sign of flair - surely thats one of the significant problems we face in determining our health as the difference between hemmies and colonic blood is huge.

How do we get round that? Do we loof for other symptoms like D? Number of BM's? Pain? It's frustrating.

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 8/31/2008 10:38 AM (GMT -6)   
London, unfortunately I have had hemmorhoids/fissures for quite some time. Some days they are better than others. I wish I had an answer for you..... Blessings, Julie
Diagnosed with Crohn's March 2006
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 11mg/day, Imuran 50mg, Miralax as needed, Prevacid 30mg, Vit B12
Paxil 40mg daily (for Panic disorder)
Xanax .5mg as needed (for anxiety attacks)
 
 
 
 
 


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14994
   Posted 8/31/2008 11:31 AM (GMT -6)   
I will tell you London that I bet the majority of us have hemi's. And most of us will occasionally see a spot of blood too when our stools are harder or too much D. Those alone can cause irritation to the hemi's. You should try taking stool softners or maybe a fibre supplement to help your stools to soften up and I bet you quit seeing those little bits of blood. I think if it was blood from the colon you would see it more often and alot more blood. JMHO
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 790
   Posted 8/31/2008 12:08 PM (GMT -6)   
I do see it quite often, virtually every bowel movement, but as you say it isn't much, it's small drops, some streaks and some on tissue. I will keep at the fibre supplements and see how I do. Otherwise I am fine, well I have always been the same before during and after meds!

Diagnosis Oct 07 and then Aug 08: 2 Patches of Mild Chrohn's Colitis (unconfirmed)
Medication: 4000mg Pentasa a day, 5mg Clipper Steroid (Beclometasone dipropionate)


LittleSisSmurf
Regular Member


Date Joined Apr 2006
Total Posts : 164
   Posted 8/31/2008 2:56 PM (GMT -6)   
I have been using the suppositories off and on for a year now. I use two or three a day depending on the amount of blood coming out. Im not sure if its OK to use more than 2 but ..what ever works for me rite. I hope my flare ends soon. im taking 8 tabs of pred and the suppositories plus, my imuran. Anyone who has flared near the colon and had a good recovery? Im just wondering bcuz im slowly loosing the ability to hold my bm's in and wondering if it will cause permanent damage? Is it just going to get worst?  I guess there are sooo many variable's though.  Man, flaring there sucks bcuz im dealing with the constipation and runny bloody bm's at the same time.
 
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