Welcome to the forums. Sorry to hear about everything your going through. Ive been tapering off of 100mg of prednisone for a while now, I'm currently down to 75MG and starting to feel weak and very tired too, so my doctor prescribed me vitamin B12 shots, maybe thats something you might want to look into and ask your doctor about. As for the Humira, I take it once a week, it is kinda painful but only lasts a couple seconds...I'm not sure why it was so bad for you, did you leave it out of the fridge for like 30 mins before you had the injection? When the medication is cold it does tend to burn extremely bad, its also thicker when its cold so it goes in slower.