Question about nausea

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sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 9/27/2008 11:20 AM (GMT -7)   
Hi all...  So, in the past couple years I've had many experiences vomiting from pain, but never really experienced nausea with my Crohn's.  For the past week and a half, every day I've felt really nauseous.  It's driving me nuts!  I just wondered, for those who have dealt with this, what are some reasons to cause the nausea? 
 
Things are moving along fine, so no blockage thoughts in my mind.  I am only taking the budesonide suppositories (3mg nightly) and on my final week of Tysabri.  (Last infusion 3 weeks ago...  Skipping next Friday's infusion to "see what happens")  I have even stopped the Xifaxan, though I *know* that wouldn't cause me nausea.
 
Anyone with thoughts/wisdom?  Thanks!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl


Mac_Gyver
Regular Member


Date Joined Aug 2007
Total Posts : 350
   Posted 9/27/2008 1:33 PM (GMT -7)   
Not really sure. I have always had a little nausea here and there and I have taken hyoscyamine as needed. Maybe just nervousness around going of tysabri?
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ImAud
Regular Member


Date Joined Jul 2008
Total Posts : 113
   Posted 9/27/2008 2:10 PM (GMT -7)   
did you ever look into seeing if you may have a stomach ulcer?? i dont mean to scare you but it could be a possiblity!..my twin sister who has ulcerative colitis got one from vomiting all the time with her UC..im starting to think i may have one because i get sick all the time too and lose my appetite..but of course crohn's can affect the whole GI track so who knows...but definitely look into it..im telling my dr. when i go see him tuesday..he may want to do an endoscopy to look for more problems!!

 


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 9/27/2008 2:19 PM (GMT -7)   
Well, the xifaxan might cause nausea indirectly. It is killing bacteria in your gut. Dead bacteria release something called endotoxins. If we assume that your gut permeability is up - usually a good bet for Crohn's - the endotoxins enter the blood. The liver is the organ that removes toxins like that from your blood. The toxin load is high enough to overload the liver, so nausea might come from a stressed liver.

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 9/27/2008 6:41 PM (GMT -7)   
FinalMacGyver -- Thanks for the thoughts. You know... I think I feel a bit on the peaceful side about taking a drug holiday. It will help me to know if it's really helping or not.

ImAud -- oh boy. Well, I had a chest/abdominal/pelvic CT on Monday (year follow-up test for the Prochymal study), so I guess I will know if that's the case. Good timing!

Keeper -- I haven't been good about my VSL#3. Guess I'd best hop to it and see if that helps! I've been just trying to elimate putting things in me as much as possible, but that's a good thing to put in me! Only had a half potato and tiny bit of rice today. And lots of water. Am eating dinner soon though!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl

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