FDA Announces 20 Dangerous Drugs You Should NOT Be On

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CrazyHarry
Veteran Member


Date Joined Mar 2006
Total Posts : 1034
   Posted 9/29/2008 10:44 AM (GMT -7)   
thought some of you might find this interesting. from mercola.com:


A 2007 federal law requires the FDA to disclose all its investigations into reports of possibly drug-related adverse events. The first of this series of quarterly reports has been released. It includes adverse events reported between January 1 and March 31, 2008.

Here's the list of drugs and the adverse events that have been reported:

1. Arginine Hydrochloride Injection (R-Gene 10) -- Pediatric overdose due to labeling and packaging confusion
2. Desflurane (Suprane) -- Cardiac arrest
3. Duloxetine (Cymbalta) -- Urinary retention
4. Etravirine (Intelence) -- Hemarthrosis (blood in a joint)
5. Fluorouracil Cream (Carac) and Ketoconazole Cream (Kuric) -- Adverse events due to name confusion
6. Heparin -- Anaphylactic-type (life-threatening allergic) reactions
7. Icodextrin (Extraneal) -- Hypoglycemia (low blood sugar)
8. Insulin U-500 (Humulin R) -- Dosing confusion
9. Ivermectin (Stromectol) and Warfarin -- Drug interaction
10. Lapatinib (Tykerb) -- Hepatotoxicity (liver toxicity)
11. Lenalidomide (Revlimid) -- Stevens-Johnson syndrome (a deadly drug reaction)
12. Natalizumab (Tysabri) -- Skin melanomas (deadly skin cancer)
13. Nitroglycerin (Nitrostat) -- Overdose due to labeling confusion
14. Octreotide Acetate Depot (Sandostatin LAR) -- Ileus (bowels not moving)
15. Oxycodone Hydrochloride Controlled-Release (OxyContin) -- Drug misuse, abuse, and overdose
16. Perflutren Lipid Microsphere (Definity) -- Cardiopulmonary reactions (lung/heart problems)
17. Phenytoin Injection (Dilantin) -- Purple glove syndrome (discoloration, pain, and swelling of the hand that may lead to amputation)
18. Quetiapine (Seroquel) -- Overdose due to sample pack labeling confusion
19. Tebivudine (Tyzeka) -- Peripheral neuropathy (tingling or numbness in the extremities)
20. Tumor Necrosis Factor (TNF) Blockers -- Cancers in children and young adults

Sources:

* FDA September 5, 2008

* WebMD.com September 5, 2008
Crazy Harry

---------------------------------------------
Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 9/29/2008 1:06 PM (GMT -7)   
No worries for me, I don't take any of those.
Been living with Crohn's Disease for 32 years.  Currently on Asacol, Prilosec 60 mg, Estrace, Prinivil, Diltiazem, Percoset prn for pain and Calcium.  Resections in 2002 and 2005.  Recently diagnosed with Fibromyalgia and doing tests to see if I have Inflammatory Arthritis or AS.


Illini
Regular Member


Date Joined Dec 2007
Total Posts : 298
   Posted 9/29/2008 2:25 PM (GMT -7)   
I don't think the FDA is telling you not to take these drugs... Just giving people updates so they can make an informed decision. There is a cost-benefit analysis to be made.

Re: the Tysabri melanomas--I read the paper a while back in the NEJM. Basically it is a concern if you have pre-existing moles on the skin. One woman had a family history of melanoma and both had MS, not Crohn's.
July 2007 Drug-Induced Liver Injury
January 2008 Crohn's Ileitis
Currently trying...
Entocort, Enteral Nutrition, Omega-3 (Flax Oil and Fish Oil), VSL#3, Vitamin E


meowese
Regular Member


Date Joined Jan 2008
Total Posts : 121
   Posted 9/29/2008 2:26 PM (GMT -7)   
I take Cymbalta, should I be worried? I was going to try Wellbutrin but I heard that there were seizure problems and that sounds worse...
Crohn's (diagnosed in 2006 and currently in remission), severe migraines, Seborrheic Derm., Hemolytic Uremic Syndrome (1994), chronic pain, ulcers/GERD and possibly Fibromyalgia? Medications: Nexium, Pentasa, Percocet and Vicodin as needed, Flintstone Vitamins (my favorite part!), calcium and magnesium supplements, vitamin D once weekly. I follow a low fiber, low residue diet.


Zanne
Veteran Member


Date Joined Apr 2005
Total Posts : 3763
   Posted 9/29/2008 2:30 PM (GMT -7)   
I think we all have to weigh the benefits of each drug vs the cost. I just got home from the ER having spent the last 4 days at home with an allergic reaction to an antibiotic, so every drug can kill someone! Personally, I am not on any of the above, but IF my doctor suggested one of them I would listen to the reasons, do the research and then make an informed decision. As in all things in life, it comes down to making your own choices about what is important. When it comes to most CD drugs, I choose to make the most of TODAY, because tomorrow may not come. It may be a drug reaction, or a bus, but something is going to get us and who knows when, so I'll take today over tomorrow.
Suzanne

CD 19 years offically, 29 unofficially. 3 resections '93, '95 '97
Symptoms constantly but all tests show only minor ulcerations. Currently having multiple episodes of gastritis with no known cause.


Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....


LMills
Veteran Member


Date Joined Apr 2008
Total Posts : 1753
   Posted 9/29/2008 3:12 PM (GMT -7)   
Interesting but I'll still stick with humira.
I just hope that people use that to make an informed decision, not take it the absolute wrong way..
20 years old, Diagnosed with severe Crohn's and colitis in May of 2008.
Currently taking:
Prednisone, pentasa, alinia, bentyl, prilosec, tandem plus, and the occasional ultracet
Surgery for ectopic pregnancy(very possibly due to Crohn's inflammation) in July of 2008.
Due to start Imuran September 17 depending on blood results.


Squattie
Veteran Member


Date Joined Jul 2005
Total Posts : 669
   Posted 9/29/2008 4:05 PM (GMT -7)   
Who names these drugs, anyway? They should just put numbers to them instead of names. I can't pronounce half of them.
.....Squattie


78SilvAnniv
Regular Member


Date Joined Apr 2008
Total Posts : 289
   Posted 9/29/2008 6:54 PM (GMT -7)   
I was surprised to see #9 Ivermectin listed.  Ivermectin is the active ingredient in the de-wormers I give my horses.  I wasn't aware it was used for people, too.  I mean, I know some drugs can be used for many different species, but I guess I am used to people meds being used for animals and not what I consider to be an animal med being used for people.
I have the ability of single-minded determination and accurate project focu....Hey, look, a cat!
 
Crohn's and UC are pretty darn crappy, but if you can't laugh at yourself, you'll cry. 
I'd much rather laugh.
2001 Dx'd with UC.  No remission.  5/2008 surgery, removal of 6" of left side colon.  Dx changed to Crohn's.  Remission for 8-9wks after surgery, symptoms returning after resuming 6MP.


Jen77
Veteran Member


Date Joined Mar 2006
Total Posts : 2689
   Posted 9/29/2008 7:16 PM (GMT -7)   
With lymphoma already heavily in my family, that sure is a big concern for me. I wonder if knowing it's in the family, if they'll take that in to consideration. That risk takes away so many Crohn's meds for me.
~Jennifer
 
Diagnosed with Crohn's Disease 2/06 after sever GI bleed. Has been suffering since 1998. History of rectal fistula and gallbladder removal. Taking Asacol, Questran, Toprol XL (for high blood pressure). Tapered off prednisone a month ago!


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 9/29/2008 7:51 PM (GMT -7)   
Here is the link. Technically the article is titled "20 Drugs the FDA is Watching"
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine
--rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--methylpred - finally off 6/15/08, tried Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08
--single mom to 10-yr-old girl


CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 9/30/2008 6:15 AM (GMT -7)   
78SilvAnniv said...
I was surprised to see #9 Ivermectin listed.  Ivermectin is the active ingredient in the de-wormers I give my horses.  I wasn't aware it was used for people, too.  I mean, I know some drugs can be used for many different species, but I guess I am used to people meds being used for animals and not what I consider to be an animal med being used for people.

MANY drugs are released for veterinary use prior to their being approved for human use. Interesting story on Ivermectin:
 
I first read about it years ago in The Pony Journal. It was in the process or had been approved for equine use in Canada. The University of Michigan inadvertently killed several horses w/the injectable form but had good luck when it was administered orally. Eventually it was used for worming dogs and it turned out that Collies and Collie-related breeds had a problem w/Ivermectin crossing the blood-brain barrier and severe comas, complications and deaths. One of the scientists working on the development of Ivermectin at Merck moved over to working for Ciba-Giegy (sp?). He took his Ivermectin knowledge and expertise w/him and developed milbemycin (sp? and I've forgotten the brand name now) by changing one molecule supposedly making it safer for Collies and Collie related breeds. Merck sued Ciba-Geigy and won. But meanwhile, Merck also donated beaucoup amounts of Ivermectin to a country in Africa that had epidemic proportions of "river blindness" amongst its citizens. Worms actually migrating to the eyes of humans. Ivermectin was effective in destroying those worms in its victims and thus began some human use of Ivermectin. Relatively recently a test has been developed to determine which Collies would be susceptible to severe blood-brain barrier penetration by Ivermectin and which Collies can safely receive Ivermectin. I'm not sure if the test applies to other breeds as well. (Collies and Collie-related breeds has the highest incidence of severe side effects but individuals in other unrelated breeds also encountered the problems is smaller numbers).
 
All that being said: those drugs listed are NOT drugs FDA is pulling off the market, they are NOT drugs that crohnies should NOT be on, they ARE drugs that you and your doctor should give consideration to the risks/benefits given YOUR PARTICULAR situation and quality of life should they or a related drug be indicated for your particular symptoms.
 


Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Post Edited (CrohnieToo) : 9/30/2008 8:22:00 AM (GMT-6)


frank j
Regular Member


Date Joined Jun 2006
Total Posts : 341
   Posted 9/30/2008 1:15 PM (GMT -7)   
Mods: Would you please change the title of this thread? It is misleading and incorrect - also doesn't appear to be what the author intended based on the body of the original message. Either way, this could be misconstrued - the FDA is NOT telling people to stop these drugs.

EMom
Veteran Member


Date Joined Aug 2007
Total Posts : 990
   Posted 9/30/2008 1:36 PM (GMT -7)   
the link from the FDA:

http://www.fda.gov/cder/aers/potential_signals/potential_signals_2008Q1.htm?source=time
Mom to 16 year old boy diagnosed in June, 2007.
Omega 3s, digestive enzymes, probiotics, vit. C, calcium w/D3, a good multivitamin and SCD legal yogurt
Started The Maker's Diet in Sept. '07. Gradually learning/using more SCD recipes, too! (cooking challenged)

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