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New Member

Date Joined Oct 2008
Total Posts : 5
   Posted 10/2/2008 9:40 PM (GMT -6)   
I will be having my second dose of Cimzia tomorrow.  My main concern is that I am still having a lot diarrhea.  How long does it take for Cimzia to kick in?

Regular Member

Date Joined Sep 2006
Total Posts : 237
   Posted 10/6/2008 1:34 AM (GMT -6)   
My intent is certainly not to make you weary....however, I just got a new Gastroenolgist and he told me that Cimzia was the number 4 out of four for treatments.  The first, I truly can not remember.  The second was Humira.  The third was Remicaide and the last was Cimzia.  I was on Remicade for two years and just tested positive for TB, and have a numbing sensation in my right knee.  I am, however, starting Humira in two weeks after my Infectious Disease Dr and Gastro Doctor talk.  All I can say is do the research..

Regular Member

Date Joined Feb 2003
Total Posts : 401
   Posted 10/6/2008 3:50 AM (GMT -6)   
I was in the clinical trial for Cimzia last year.  I have been on Remicade which is usually the first TNF alpha blocking drug they try wth CD.  It worked but I eventually had a pretty scary allergic reaction.  After that I took Humira, which is typically given to people who had a good initial reaction to remicade.  It also worked for me but only for about a year.  Cimzia is the third in line and also given to people who had a good reaction to the first two drugs.  It took me about four shots to really notice any type of positive results.  It did help me drastically though.  Of course as I find with all these "biologic drugs" it also worked for about a year.  My GI said this is pretty typical for these drugs which is why people usually go from one to the next in such order.  I would say to just try to stick it out and hopefully you will get some relief soon!  If the other drugs helped you there is a pretty good chance Cimzia will too! 

"Just when the caterpillar thought the world was over, it became a butterfly"

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 10/6/2008 10:27 AM (GMT -6)   
And what do you do when Cimzia stops working??
Dx'ed in 1999. No surgeries.

Current meds: 100 mg 6MP. Just finished prednisone taper. Udo's Choice Probiotics (30 billion).
Betaine, digestive enzymes, Candicin (oil of oregano capsules), Beta Sitosterol.

Veteran Member

Date Joined Aug 2007
Total Posts : 884
   Posted 10/7/2008 12:08 PM (GMT -6)   

kjl, I noticed it working within a few weeks, but I was getting bi-weekly injections on a clinical trial, compared to monthly injections that I believe most people get now that it's approved. 

tiamarie, I'm not sure on what basis this dr is rating the drugs, but everyone reacts differently, so I would be hesitant to put too much faith in his ratings.  My rheumy said that her arthritis patients overall have seen the most results on Remicade, but it didn't work for many of us, so you gotta go with what works for you.    

flutterby, I think it's interesting that your doctor mentioned the one year rule.  I've always noticed that I have to switch meds after about a year (started with acid reflux meds) and after a year on a clinical trial for Cimzia, it seemed to not work as well anymore either.  Now I have switched to Humira but have not been happy with the results.   

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 

Regular Member

Date Joined Oct 2006
Total Posts : 367
   Posted 10/7/2008 10:31 PM (GMT -6)   
Hi KJL. It sounds like you are still in the initial dose--the 0, 2, 4 week doses; then you go to every four weeks. I've heard people who felt a difference after the first dose and I've heard people who took a couple of months to feel better. I hope you feel better soon, but be patient as it may take a little while.

Tiamarie--I think you're physician was refering to the order the anti-tnfs came to market. Remicade came out in 1998 and is an infusion. Humira, a subcutaneous shot was approved about a year ago. And Cimzia, which was approved early this year and is also a subcutaneous injection.

If you look at the package insert on all three, the safety information is basically the same on all three.
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