Crohns in siblings?

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73monte
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Date Joined Mar 2007
Total Posts : 1499
   Posted 10/18/2008 3:50 AM (GMT -7)   
Does anyone have any info on the likelihood of a sibling having Crohn's? My daughter was diagnosed at 13, and now with my son approaching the same age, I find myself tending to worry if he gets a bug, fever, or stomach ache. I've checked the around and can't seem to find any research data to indicate how much more likely a sibling is to develop Crohn's.
 
I used to work with a girl who was diagnosed at 23, within months, her twin sister also was diagnosed with Crohn's. 
 
 
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Initially, 9 weeks of Prednisone, currently taking 2000mgs of Pentasa.


kyle Nelson
Regular Member


Date Joined Sep 2008
Total Posts : 28
   Posted 10/18/2008 5:24 AM (GMT -7)   
while this is a far cry from scientific research, none of my siblings, nor any of the siblings of fellow crohns patients that i know, have any signs of disease

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 10/18/2008 9:39 AM (GMT -7)   
There are stats on one parent having CD that for their offspring there is a -10 to -15 fold increased risk to their offspring developing an IBD as well (either CD or UC) and in the research it does mention that if one twin has CD there is a 40-60% chance the other twin will also get CD, it's a matter of it being triggered for each person as well.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


lil-momma
Regular Member


Date Joined Feb 2008
Total Posts : 132
   Posted 10/18/2008 10:42 AM (GMT -7)   
I thought that I read somewhere that if a parent has UC or CD then their child has a 20% greater risk and if a person has either, their siblings have a 30% greater risk.  I don't recall where I read it or whether it is accurate.   When have a few minutes I will try to find it.  Best wishes!

Dx w/UC in 2001 - controlled by diet.
Mother to 15 yr old daughter dx w/CD 9/07-  she had surgery for abcesses 11/07.  She is taking multi-vit, iron for anemia, bentyl prn, prilosec 20mg-x2, pentasa  500mg-x5, prednisone 10mg-x6, 6 mp 50mg-x3, Flagyl 250mg-x3


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 10/18/2008 12:00 PM (GMT -7)   
The research I quote above is from a Dr. Kevin Rioux from the University of Alberta whom is an IBD researcher on the genetics and inheritance of IBD. He does state that a significant percentage (~20%) of IBD patients have a relative that also suffers from IBD, but when it comes to a parent with an IBD the chances of passing it to an offspring is 10- to 15- fold increased risk.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


lil-momma
Regular Member


Date Joined Feb 2008
Total Posts : 132
   Posted 10/18/2008 1:49 PM (GMT -7)   
Pb4- I hope I didn't offend you as I certainly was not questioning your input. You are always able to give such helpful information and I rely on your posts often.
Dx w/UC in 2001 - controlled by diet.
Mother to 15 yr old daughter dx w/CD 9/07-  she had surgery for abcesses 11/07.  She is taking multi-vit, iron for anemia, bentyl prn, prilosec 20mg-x2, pentasa  500mg-x5, prednisone 10mg-x6, 6 mp 50mg-x3, Flagyl 250mg-x3


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 10/18/2008 2:53 PM (GMT -7)   
Oh gosh no, not at all, I just thought I'd refer back to my CCFC journal I have where the info was printed...I would imagine that some stats might differ from the US to Candad and even europe...believe me I didn't take it that way at all, I knew I read something about the 20% thing too, and then the specific info of parent to offspring, funny how that differs from 20% relative and 10- to 15- fold from parent to offspring.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Bspbtwins
Regular Member


Date Joined Jan 2008
Total Posts : 27
   Posted 10/18/2008 5:48 PM (GMT -7)   
I don't know about the research and the stats that prove it one way or another but I do know this...
I have Crohn's
My brother has it
and My father.
 
 
Diagnosed with CD in Jan. 2008.  Resection in August 2008.
Meds Currently on: Azathioprine 50mg.
I choose joy... I will invite my God to be the God of circumstance. I will refuse the temptation to be cynical... the tool of the lazy thinker. I will refuse to see people as anything less than human beings, created by God. I will refuse to see any problem as anything less than an opportunity to see God. ~Max Lucado
                          


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 10/18/2008 5:51 PM (GMT -7)   
Ya, in the same article (that I've been quoting from above) it states that there are cases of familial IBD where nearly every member of one family has the condition...both your mom and dad having it sure is some bad luck eh...it's probably becoming more and more common for IBDers to meet and get into relationships with one another because now a days there's even more prevalance of the disease then ever before.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Celey
Veteran Member


Date Joined May 2007
Total Posts : 1284
   Posted 10/18/2008 7:52 PM (GMT -7)   
I've been worried about my siblings getting Crohn's... Recently, I heard that my brother was having some stomach problems...

And the doctor said he had gastritis...

But my brother didn't mention that I had Crohn's disease... and he doesn't want to get a colonoscopy done. :(... Been trying to convince him to get one done, but he won't hear of it. He says he's doing fine, the doctor put him on some medicine or something that he says is helping him...

So, I guess as long as he's doing okay....

Still... I really worry... :(
I think I am being picked on by life, sometimes. But's that okay. Life and I are good buddies... I know life doesn't mean no harm. It just is the way it is. I can accept that.


ImAud
Regular Member


Date Joined Jul 2008
Total Posts : 113
   Posted 10/19/2008 7:48 PM (GMT -7)   
i've been told by my GI and through my own research that if you have a sibling with crohns or ulcertive colitis you have a 30% more of chance of getting it and if you have a twin with it, it's a 40% chance. My twin sister was diagnosed with UC when she was 16...i'm 21 and just got diagnosed with Crohns..what are the odds? lol...o well!!

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 10/19/2008 7:53 PM (GMT -7)   
40-60% according to research in Canada for twins...weird thing is your twin sis has UC and you have CD...according to Dr.Kevin Rioux if one twin has CD the other has a 40-60% chance of also getting CD...of course much more still needs to be learned.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Kittikatt
Regular Member


Date Joined Jul 2004
Total Posts : 422
   Posted 10/20/2008 4:21 AM (GMT -7)   
I have a coworker who has twins. One of her twins was Dx with a major case of CD at the age of 18 and really struggles with it daily. Her twin sister however, does not (at least now) have the disease.
Diagnosed in October, 2004 at age 32.
36/F/SC
Current Rx's: Colazal (generic), Nexium (generic), Ferrous Sulfate, Librax, One-A-Day multivitamin, Probiotic, Omega-3 Fish Oil, Vitamin D, Vitamin A, Calcium-Magnesium-Zinc, Cranberry pills, Chromium Picolinate
Secondary conditions: mouth ulcers, joint pain, swelling ankles, extreme fatigue
Previous/occasional Rx's: 20mg Prednisone taper, Flagyl, Levaquin
No surgeries to date


anglfrmhvn69
Regular Member


Date Joined Dec 2006
Total Posts : 297
   Posted 10/20/2008 7:48 AM (GMT -7)   
hi i was just reading i dont have crohn's i got uc but i'm the only sibling that seemed to have gotten this horrible disease. i have 1 full blooded sister and 3 half sister's and 1 half brother and we all have the same dad. and i got the inheritance from my dad's side.

pamela

 i was diagnosed with uc on april.16,2003. had my sec. colonoscopy on aug.22,2008 came back normal.

quit smoking almost a year ago,been having little flares since then.

i also take nexium 40mg once a day for acid reflux.

take one multivitamin a day

                                                                       

 


tmlindsey
Regular Member


Date Joined Sep 2005
Total Posts : 78
   Posted 10/20/2008 7:55 AM (GMT -7)   
Stranger things can happen..... I was diagnosed with CD in 1997. I have two full blooded brothers neither have any stomach complications. I have two step brothers, one on my mom's side and one one on my dad's side. Both of my step brothers have CD. Neither three of us are blood related in any way. Talk about weird.
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